Recombinant Human Neuropilin-2 Fc Chimera Protein, CF | R&D Systems 2215-N2 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Neuropilin-2 Fc Chimera Protein, CF

catalog :

2215-N2

quantity :

25 ug

price :

339 USD

citations: 6

Reference
Martinez Martin N, Marcandalli J, Huang C, Arthur C, Perotti M, Foglierini M, et al. An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor. Cell. 2018;174:1158-1171.e19 pubmed publisher
Harris N, Davydova N, Roufail S, Paquet Fifield S, Paavonen K, Karnezis T, et al. The propeptides of VEGF-D determine heparin binding, receptor heterodimerization, and effects on tumor biology. J Biol Chem. 2013;288:8176-86 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Narazaki M, Segarra M, Hou X, Tanaka T, Li X, Tosato G. Oligo-guanosine nucleotide induces neuropilin-1 internalization in endothelial cells and inhibits angiogenesis. Blood. 2010;116:3099-107 pubmed publisher
Fassold A, Falk W, Anders S, Hirsch T, Mirsky V, Straub R. Soluble neuropilin-2, a nerve repellent receptor, is increased in rheumatoid arthritis synovium and aggravates sympathetic fiber repulsion and arthritis. Arthritis Rheum. 2009;60:2892-901 pubmed publisher
Jaalouk D, Ozawa M, Sun J, Lahdenranta J, Schlingemann R, Pasqualini R, et al. The original Pathologische Anatomie Leiden-Endothelium monoclonal antibody recognizes a vascular endothelial growth factor binding site within neuropilin-1. Cancer Res. 2007;67:9623-9 pubmed

product information

brand :

R&D Systems

master code :

2215-N2

SKU :

2215-N2-025

product name :

Recombinant Human Neuropilin-2 Fc Chimera Protein, CF

description :

The Recombinant Human Neuropilin-2 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Neuropilin-2 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

Neuropilin-2

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

140 kDa, reducing conditions

theoretical molecular weight :

120.5 kDa (monomer)

gene symbol :

NRP2

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human (rh) Neuropilin-2 Fc Chimera can bind rhVEGF165 with an apparent KD 5 nM.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

2215-N2

accessionNumbers :

Q7LBX6

applications :

Binding Activity

source :

Mouse myeloma cell line, NS0-derived human Neuropilin-2 protein Human Neuropilin-2 (Gln23-Tyr855) Accession #Q7LBX6 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

2020 USD :

339

2021 USD :

339 USD

alt names :

MGC126574, neuropilin 2, neuropilin-2, Neuropilin2, neuropilin-2a(22), neuropilin-2b(0), NP2, NPN 2, NPN2, PRO2714, receptor for VEGF165 and semaphorins class3, Vascular endothelial cell growth factor 165 receptor 2, vascular endothelial growth factor-165 receptor 2, VEGF1265R2, VEGF165R2neuropilin-2a(17)

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.