product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Neuropilin-2 Fc Chimera Protein, CF
catalog :
2215-N2-025
quantity :
25 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 9
Reference
Fornara C, Schultz E, Lilleri D, Baldanti F, RYCKMAN B, Gerna G. Fibroblast, Epithelial and Endothelial Cell-Derived Human Cytomegalovirus Strains Display Distinct Neutralizing Antibody Responses and Varying Levels of gH/gL Complexes. Int J Mol Sci. 2023;24: pubmed publisher
Braun B, Laib Sampaio K, Kuderna A, Widmann M, Sinzger C. Viral and Cellular Factors Contributing to the Hematogenous Dissemination of Human Cytomegalovirus via Polymorphonuclear Leukocytes. Viruses. 2022;14: pubmed publisher
Dutta S, Polavaram N, Islam R, Bhattacharya S, Bodas S, Mayr T, et al. Neuropilin-2 regulates androgen-receptor transcriptional activity in advanced prostate cancer. Oncogene. 2022;41:3747-3760 pubmed publisher
Martinez Martin N, Marcandalli J, Huang C, Arthur C, Perotti M, Foglierini M, et al. An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor. Cell. 2018;174:1158-1171.e19 pubmed publisher
Harris N, Davydova N, Roufail S, Paquet Fifield S, Paavonen K, Karnezis T, et al. The propeptides of VEGF-D determine heparin binding, receptor heterodimerization, and effects on tumor biology. J Biol Chem. 2013;288:8176-86 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Narazaki M, Segarra M, Hou X, Tanaka T, Li X, Tosato G. Oligo-guanosine nucleotide induces neuropilin-1 internalization in endothelial cells and inhibits angiogenesis. Blood. 2010;116:3099-107 pubmed publisher
Fassold A, Falk W, Anders S, Hirsch T, Mirsky V, Straub R. Soluble neuropilin-2, a nerve repellent receptor, is increased in rheumatoid arthritis synovium and aggravates sympathetic fiber repulsion and arthritis. Arthritis Rheum. 2009;60:2892-901 pubmed publisher
Jaalouk D, Ozawa M, Sun J, Lahdenranta J, Schlingemann R, Pasqualini R, et al. The original Pathologische Anatomie Leiden-Endothelium monoclonal antibody recognizes a vascular endothelial growth factor binding site within neuropilin-1. Cancer Res. 2007;67:9623-9 pubmed
product information
brand :
R&D Systems
master code :
2215-N2
SKU :
2215-N2-025
product name :
Recombinant Human Neuropilin-2 Fc Chimera Protein, CF
unit size :
25 ug
seo description :
The Recombinant Human Neuropilin-2 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Neuropilin-2 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.
target :
Neuropilin-2
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
dilution :
Binding Activity
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
140 kDa, reducing conditions
theoretical molecular weight :
120.5 kDa (monomer)
gene symbol :
NRP2
details of functionality :
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human (rh) Neuropilin-2 Fc Chimera can bind rhVEGF165 with an apparent KD 5 nM.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q7LBX6
applications :
Binding Activity
source :
NS0-derived Recombinant Human Neuropilin-2 Fc Chimera Protein, CF
USD :
432 USD
alt names :
MGC126574, neuropilin 2, neuropilin-2, Neuropilin2, neuropilin-2a(22), neuropilin-2b(0), NP2, NPN 2, NPN2, PRO2714, receptor for VEGF165 and semaphorins class3, Vascular endothelial cell growth factor 165 receptor 2, vascular endothelial growth factor-165 receptor 2, VEGF1265R2, VEGF165R2neuropilin-2a(17)
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.