Recombinant Human ADAMTS5 Protein, CF | R&D Systems 2198-AD product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ADAMTS5 Protein, CF

catalog :

2198-AD

quantity :

1 mg

price :

8715 USD

citations: 9

Reference
Fontanil T, Mohamedi Y, Moncada Pazos A, Cobo T, Vega J, Cobo J, et al. Neurocan is a New Substrate for the ADAMTS12 Metalloprotease: Potential Implications in Neuropathies. Cell Physiol Biochem. 2019;52:1003-1016 pubmed publisher
Seuffert F, Weidner D, Baum W, Schett G, Stock M. Upper zone of growth plate and cartilage matrix associated protein protects cartilage during inflammatory arthritis. Arthritis Res Ther. 2018;20:88 pubmed publisher
Kehlet S, Bager C, Willumsen N, Dasgupta B, Brodmerkel C, Curran M, et al. Cathepsin-S degraded decorin are elevated in fibrotic lung disorders - development and biological validation of a new serum biomarker. BMC Pulm Med. 2017;17:110 pubmed publisher
Li F, Song R, Ao L, Reece T, Cleveland J, Dong N, et al. ADAMTS5 Deficiency in Calcified Aortic Valves Is Associated With Elevated Pro-Osteogenic Activity in Valvular Interstitial Cells. Arterioscler Thromb Vasc Biol. 2017;37:1339-1351 pubmed publisher
Fontanil T, Álvarez Teijeiro S, Villaronga M, Mohamedi Y, Solares L, Moncada Pazos A, et al. Cleavage of Fibulin-2 by the aggrecanases ADAMTS-4 and ADAMTS-5 contributes to the tumorigenic potential of breast cancer cells. Oncotarget. 2017;8:13716-13729 pubmed publisher
Lemarchant S, Pomeshchik Y, Kidin I, KÃ¤rkkÃ¤inen V, Valonen P, Lehtonen S, et al. ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. Mol Neurodegener. 2016;11:10 pubmed publisher
He Y, Zheng Q, Jiang M, Sun S, Christiansen T, Kassem M, et al. The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants. PLoS ONE. 2015;10:e0122700 pubmed publisher
Kumar S, Sharghi Namini S, Rao N, Ge R. ADAMTS5 functions as an anti-angiogenic and anti-tumorigenic protein independent of its proteoglycanase activity. Am J Pathol. 2012;181:1056-68 pubmed publisher
Devel L, Beau F, Amoura M, Vera L, Cassar Lajeunesse E, Garcia S, et al. Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins. J Biol Chem. 2012;287:26647-56 pubmed publisher

product information

brand :

R&D Systems

master code :

2198-AD

SKU :

2198-AD-01M

product name :

Recombinant Human ADAMTS5 Protein, CF

description :

The Recombinant Human ADAMTS5 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human ADAMTS5 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

ADAMTS5

category :

Proteins and Enzymes

unit size :

1 mg

buffer :

Lyophilized from a 0.2 µm filtered solution in Sodium Acetate, CaCl2 and NaCl.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

51 kDa, reducing conditions

theoretical molecular weight :

41 kDa

gene symbol :

ADAMTS5

details of functionality :

Measured by its ability to cleave the fluorogenic peptide substrate, Abz-TEGEARGSVI-Dap(Dnp)-KK-NH2. The specific activity is 10 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

2198-AD

accessionNumbers :

Q9UNA0

applications :

Enzyme Activity

source :

Mouse myeloma cell line, NS0-derived human ADAMTS5 protein Ser262-Pro622, with a C-terminal 10-His tag

2020 USD :

8300

2021 USD :

8715 USD

alt names :

A disintegrin and metalloproteinase with thrombospondin motifs 11, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 5 (aggrecanase-2), ADAM metallopeptidase with thrombospondin type 1 motif, 5, ADAM-TS 11, ADAM-TS 5, ADAMTS11, ADAMTS-11, ADAM-TS5, ADAMTS-5, ADMP2, ADMP-2, ADMP-2A disintegrin and metalloproteinase with thrombospondin motifs 5, Aggrecanase 2, Aggrecanase-2, disintegrin-like and metalloprotease with thrombospondin type 1 motif, 510ADAMTS11FLJ36738, EC 3.4.24, EC 3.4.24.-, EC 3.4.24.14, EC 3.4.24.82

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -70 °C under sterile conditions after reconstitution.