Recombinant Human ADAMTS5 Protein, CF | R&D Systems 2198-AD-020 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ADAMTS5 Protein, CF

catalog :

2198-AD-020

quantity :

20 ug

price :

541 USD

more info or order :

R&D Systems product webpage

citations: 11

Reference
Kuczynski Noyau L, Karmann S, Alberton P, Martínez Corral I, Nampoothiri S, Sauv xe9 F, et al. A plastic aggrecan barrier modulated by peripheral energy state gates metabolic signal access to arcuate neurons. Nat Commun. 2024;15:6701 pubmed publisher
Kirman D, Renganathan B, Chui W, Chen M, Kaya N, Ge R. Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis. Cell Death Dis. 2022;13:172 pubmed publisher
Taylor S, Whitfield M, Barratt J, Didangelos A. The Metalloproteinase ADAMTS5 Is Expressed by Interstitial Inflammatory Cells in IgA Nephropathy and Is Proteolytically Active on the Kidney Matrix. J Immunol. 2020;205:2243-2254 pubmed publisher
Fontanil T, Mohamedi Y, Moncada Pazos A, Cobo T, Vega J, Cobo J, et al. Neurocan is a New Substrate for the ADAMTS12 Metalloprotease: Potential Implications in Neuropathies. Cell Physiol Biochem. 2019;52:1003-1016 pubmed publisher
Seuffert F, Weidner D, Baum W, Schett G, Stock M. Upper zone of growth plate and cartilage matrix associated protein protects cartilage during inflammatory arthritis. Arthritis Res Ther. 2018;20:88 pubmed publisher
Li F, Song R, Ao L, Reece T, Cleveland J, Dong N, et al. ADAMTS5 Deficiency in Calcified Aortic Valves Is Associated With Elevated Pro-Osteogenic Activity in Valvular Interstitial Cells. Arterioscler Thromb Vasc Biol. 2017;37:1339-1351 pubmed publisher
Fontanil T, Álvarez Teijeiro S, Villaronga M, Mohamedi Y, Solares L, Moncada Pazos A, et al. Cleavage of Fibulin-2 by the aggrecanases ADAMTS-4 and ADAMTS-5 contributes to the tumorigenic potential of breast cancer cells. Oncotarget. 2017;8:13716-13729 pubmed publisher
Lemarchant S, Pomeshchik Y, Kidin I, KÃ¤rkkÃ¤inen V, Valonen P, Lehtonen S, et al. ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. Mol Neurodegener. 2016;11:10 pubmed publisher
He Y, Zheng Q, Jiang M, Sun S, Christiansen T, Kassem M, et al. The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants. PLoS ONE. 2015;10:e0122700 pubmed publisher
Kumar S, Sharghi Namini S, Rao N, Ge R. ADAMTS5 functions as an anti-angiogenic and anti-tumorigenic protein independent of its proteoglycanase activity. Am J Pathol. 2012;181:1056-68 pubmed publisher
Devel L, Beau F, Amoura M, Vera L, Cassar Lajeunesse E, Garcia S, et al. Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins. J Biol Chem. 2012;287:26647-56 pubmed publisher

product information

brand :

R&D Systems

master code :

2198-AD

SKU :

2198-AD-020

product name :

Recombinant Human ADAMTS5 Protein, CF

unit size :

20 ug

seo description :

The Recombinant Human ADAMTS5 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human ADAMTS5 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

ADAMTS5

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Sodium Acetate, CaCl2 and NaCl.

conjugate :

Unconjugated

dilution :

Enzyme Activity

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

51 kDa, reducing conditions

theoretical molecular weight :

41 kDa

gene symbol :

ADAMTS5

details of functionality :

Measured by its ability to cleave the fluorogenic peptide substrate, Abz-TEGEARGSVI-Dap(Dnp)-KK-NH2. The specific activity is 10 pmol/min/╡g, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q9UNA0

applications :

Enzyme Activity

source :

NS0-derived Recombinant Human ADAMTS5 Protein, CF

USD :

541 USD

alt names :

A disintegrin and metalloproteinase with thrombospondin motifs 11, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 5 (aggrecanase-2), ADAM metallopeptidase with thrombospondin type 1 motif, 5, ADAM-TS 11, ADAM-TS 5, ADAMTS11, ADAMTS-11, ADAM-TS5, ADAMTS-5, ADMP2, ADMP-2, ADMP-2A disintegrin and metalloproteinase with thrombospondin motifs 5, Aggrecanase 2, Aggrecanase-2, disintegrin-like and metalloprotease with thrombospondin type 1 motif, 510ADAMTS11FLJ36738, EC 3.4.24, EC 3.4.24.-, EC 3.4.24.14, EC 3.4.24.82

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage