Recombinant Human ADAMTS1 Protein, CF | R&D Systems 2197-AD-020 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ADAMTS1 Protein, CF

catalog :

2197-AD-020

quantity :

20 ug

price :

541 USD

citations: 6

Reference
Peris Torres C, Plaza Calonge M, López Domínguez R, Domínguez García S, Barrientos Duran A, Carmona Saez P, et al. Extracellular Protease ADAMTS1 Is Required at Early Stages of Human Uveal Melanoma Development by Inducing Stemness and Endothelial-Like Features on Tumor Cells. Cancers (Basel). 2020;12: pubmed publisher
Fontanil T, Mohamedi Y, Moncada Pazos A, Cobo T, Vega J, Cobo J, et al. Neurocan is a New Substrate for the ADAMTS12 Metalloprotease: Potential Implications in Neuropathies. Cell Physiol Biochem. 2019;52:1003-1016 pubmed publisher
Fontanil T, Álvarez Teijeiro S, Villaronga M, Mohamedi Y, Solares L, Moncada Pazos A, et al. Cleavage of Fibulin-2 by the aggrecanases ADAMTS-4 and ADAMTS-5 contributes to the tumorigenic potential of breast cancer cells. Oncotarget. 2017;8:13716-13729 pubmed publisher
Lemarchant S, Pomeshchik Y, Kidin I, KÃ¤rkkÃ¤inen V, Valonen P, Lehtonen S, et al. ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. Mol Neurodegener. 2016;11:10 pubmed publisher
Wang Z, Luo J, Iwamoto S, Chen Q. Matrilin-2 is proteolytically cleaved by ADAMTS-4 and ADAMTS-5. Molecules. 2014;19:8472-87 pubmed publisher
Rocks N, Paulissen G, Quesada Calvo F, Munaut C, Gonzalez M, Gueders M, et al. ADAMTS-1 metalloproteinase promotes tumor development through the induction of a stromal reaction in vivo. Cancer Res. 2008;68:9541-50 pubmed publisher

product information

master code :

2197-AD

SKU :

2197-AD-020

product name :

Recombinant Human ADAMTS1 Protein, CF

unit size :

20 ug

description :

The Recombinant Human ADAMTS1 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human ADAMTS1 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

ADAMTS1

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in Sodium Acetate, CaCl2 and NaCl.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

66 kDa, reducing conditions

theoretical molecular weight :

54 kDa

gene symbol :

ADAMTS1

details of functionality :

Measured by its ability to cleave Recombinant Human Aggrecan G1-IGD-G2 Domains (Catalog # 1220-PG ).

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAD48080

applications :

Enzyme Activity

source long :

Mouse myeloma cell line, NS0-derived human ADAMTS1 protein Phe253-Ala734, with a C-terminal 10-His tag

source short :

NS0

USD :

541 USD

alt names :

a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1, ADAM metallopeptidase with thrombospondin type 1 motif, 1, ADAM-TS 1, ADAM-TS1, ADAMTS-1, C3-C5, METH1, METH-1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.