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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-11 Protein, CF
catalog :
218-IL-005/CF
quantity :
5 ug (also 25 ug)
price :
325 USD
more info or order :
citations: 24
Reference
Xu S, Yang X, Chen Q, Liu Z, Chen Y, Yao X, et al. Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosis. EBioMedicine. 2022;86:104312 pubmed publisher
Chen C, Sun M, Warzecha C, Bachu M, Dey A, Wu T, et al. HIRA, a DiGeorge Syndrome Candidate Gene, Confers Proper Chromatin Accessibility on HSCs and Supports All Stages of Hematopoiesis. Cell Rep. 2020;30:2136-2149.e4 pubmed publisher
Strikoudis A, Cieslak A, Loffredo L, Chen Y, Patel N, Saqi A, et al. Modeling of Fibrotic Lung Disease Using 3D Organoids Derived from Human Pluripotent Stem Cells. Cell Rep. 2019;27:3709-3723.e5 pubmed publisher
Mair B, Tomic J, Masud S, Tonge P, Weiss A, Usaj M, et al. Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies. Cell Rep. 2019;27:599-615.e12 pubmed publisher
Kim H, Kim D, Choi S, Kim C, Oh S, Pyo K, et al. KDM3A histone demethylase functions as an essential factor for activation of JAK2-STAT3 signaling pathway. Proc Natl Acad Sci U S A. 2018;115:11766-11771 pubmed publisher
Lewis V, Devarajan E, Card Vila M, Thomas D, Kleinerman E, Marchi S, et al. BMTP-11 is active in preclinical models of human osteosarcoma and a candidate targeted drug for clinical translation. Proc Natl Acad Sci U S A. 2017;114:8065-8070 pubmed publisher
Tsuzuki H, Arinobu Y, Miyawaki K, Takaki A, Ota S, Ota Y, et al. Functional interleukin-33 receptors are expressed in early progenitor stages of allergy-related granulocytes. Immunology. 2017;150:64-73 pubmed publisher
Hong S, Choi J, Lee S, Park Y, Park K, Lee J, et al. A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130. J Immunol. 2015;195:237-45 pubmed publisher
Zhou C, Ji J, Cai Q, Shi M, Chen X, Yu Y, et al. MTA2 enhances colony formation and tumor growth of gastric cancer cells through IL-11. BMC Cancer. 2015;15:343 pubmed publisher
Zhang X, Tao Y, Chopra M, Dujmovic Basuroski I, Jin J, Tang Y, et al. IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis. J Immunol. 2015;194:5139-49 pubmed publisher
Kwofie K, Scott M, Rodrigues R, Guerette J, Radford K, Nair P, et al. Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M. Respir Res. 2015;16:14 pubmed publisher
Simmons P, Robinson S, Munsell M, Thomas M, Javni J, Brouard N, et al. Expression of a surface antigen (MA6) by peripheral blood CD34+ cells is correlated with improved platelet engraftment and may explain delayed platelet engraftment following cord blood transplantation. Stem Cells Dev. 2015;24:1066-72 pubmed publisher
Gori J, Butler J, Chan Y, Chandrasekaran D, Poulos M, Ginsberg M, et al. Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells. J Clin Invest. 2015;125:1243-54 pubmed publisher
Boettcher S, Gerosa R, Radpour R, Bauer J, Ampenberger F, Heikenwalder M, et al. Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis. Blood. 2014;124:1393-403 pubmed publisher
Onnis B, Fer N, Rapisarda A, Perez V, Melillo G. Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells. J Clin Invest. 2013;123:1615-29 pubmed publisher
Duluc D, Corvaisier M, Blanchard S, Catala L, Descamps P, Gamelin E, et al. Interferon-gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages. Int J Cancer. 2009;125:367-73 pubmed publisher
Brechter A, Lerner U. Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression. Arthritis Rheum. 2007;56:910-23 pubmed
Gemelli C, Montanari M, Tenedini E, Zanocco Marani T, Vignudelli T, Siena M, et al. Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells. Cell Death Differ. 2006;13:1686-96 pubmed
Mandelin J, Li T, Hukkanen M, Liljeström M, Salo J, Santavirta S, et al. Interface tissue fibroblasts from loose total hip replacement prosthesis produce receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and cathepsin K. J Rheumatol. 2005;32:713-20 pubmed
Kao C, Chen Y, Thai P, Wachi S, Huang F, Kim C, et al. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J Immunol. 2004;173:3482-91 pubmed
Van der Meeren A, Mouthon M, Vandamme M, Squiban C, Aigueperse J. Combinations of cytokines promote survival of mice and limit acute radiation damage in concert with amelioration of vascular damage. Radiat Res. 2004;161:549-59 pubmed
Cork B, Tuckerman E, Li T, Laird S. Expression of interleukin (IL)-11 receptor by the human endometrium in vivo and effects of IL-11, IL-6 and LIF on the production of MMP and cytokines by human endometrial cells in vitro. Mol Hum Reprod. 2002;8:841-8 pubmed
Manz M, Miyamoto T, Akashi K, Weissman I. Prospective isolation of human clonogenic common myeloid progenitors. Proc Natl Acad Sci U S A. 2002;99:11872-7 pubmed
Curti A, Ratta M, Corinti S, Girolomoni G, Ricci F, Tazzari P, et al. Interleukin-11 induces Th2 polarization of human CD4(+) T cells. Blood. 2001;97:2758-63 pubmed
product information
master code :
218-IL/CF
SKU :
218-IL-005/CF
product name :
Recombinant Human IL-11 Protein, CF
unit size :
5 ug (also 25 ug)
description :
The Recombinant Human IL-11 Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human IL-11 Protein, CF has been validated for the following applications: Bioactivity.
target :
IL-11
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 ╡m filtered solution in PBS and EDTA.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
23 kDa, reducing conditions
theoretical molecular weight :
19 kDa
gene symbol :
IL11
details of functionality :
Measured in a cell proliferation assay using T11 mouse plasmacytoma cells. Nordan, R.P. etáal . (1987) J. Immunol. 139 :813. The ED50 for this effect is 0.02-0.12 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
P20809.1
applications :
Bioactivity
source long :
Spodoptera frugiperda , Sf 21 (baculovirus)-derived human IL-11 protein Pro22-Leu199
source short :
Sf 21 (baculovirus)
USD :
325 USD
alt names :
Adipogenesis inhibitory factor, AGIF, AGIFoprelvekin, IL11, IL-11Oprelvekin, interleukin 11, interleukin-11, Oprelvekin
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, 2 to 8 ░C as supplied.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.