Recombinant Mouse GITR Ligand/TNFSF18 (aa 47-173) Protein | R&D Systems 2177-GL-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse GITR Ligand/TNFSF18 (aa 47-173) Protein

catalog :

2177-GL-025

quantity :

25 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Sekiya T, Hibino S, Saeki K, Kanamori M, Takaki S, Yoshimura A. Nr4a Receptors Regulate Development and Death of Labile Treg Precursors to Prevent Generation of Pathogenic Self-Reactive Cells. Cell Rep. 2018;24:1627-1638.e6 pubmed publisher
Xiao X, Shi X, Fan Y, Zhang X, Wu M, Lan P, et al. GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation. Nat Commun. 2015;6:8266 pubmed publisher
Freeman B, Hammarlund E, Raué H, Slifka M. Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A. 2012;109:9971-6 pubmed publisher
Kayamuro H, Yoshioka Y, Abe Y, Katayama K, Yoshida T, Yamashita K, et al. TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant. Biochem Biophys Res Commun. 2009;384:296-300 pubmed publisher

product information

master code :

2177-GL

SKU :

2177-GL-025

product name :

Recombinant Mouse GITR Ligand/TNFSF18 (aa 47-173) Protein

unit size :

25 ug

description :

The Recombinant Mouse GITR Ligand/TNFSF18 (aa 47-173) Protein from R&D Systems is derived from NS0. The Recombinant Mouse GITR Ligand/TNFSF18 (aa 47-173) Protein has been validated for the following applications: Bioactivity.

target :

GITR Ligand/TNFSF18

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

16-26 kDa, reducing conditions

theoretical molecular weight :

16 kDa

gene symbol :

Tnfsf18

details of functionality :

Measured by its ability to stimulate mouse T cell proliferation in the presence of anti-CD3. The ED50 for this effect is 0.02-0.3 ╡g/mL in the presence of 10 ╡g/mL of a cross-linking antibody, Mouse Anti-polyHistidine Monoclonal Antibody (Catalog # MAB050 ).

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAO89011

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived mouse GITR Ligand/TNFSF18 protein Thr47-Ser173, with an N-terminal 10-His tag

source short :

NS0

USD :

432 USD

alt names :

Activation-inducible TNF-related ligand, AITRL, AITRLMGC138237, GITRL, GITRLglucocorticoid-induced TNFR-related protein ligand, Glucocorticoid-induced TNF-related ligand, hGITRLGITR ligand, TL6AITR ligand, TNFSF18, tumor necrosis factor (ligand) superfamily, member 18, tumor necrosis factor ligand superfamily member 18

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage