| Reference |
|---|
Xiong W, Jia L, Liang J, Cai Y, Chen Y, Nie Y, et al. Investigation into the anti-airway inflammatory role of the PI3Kγ inhibitor JN-PK1: An in vitro and in vivo study. Int Immunopharmacol. 2022;111:109102 pubmed publisher |
Llori xe1 n Salvador M, Byrne E, Szczepan M, Little K, Chen M, Xu H. Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cells. J Neuroinflammation. 2022;19:182 pubmed publisher |
Brandolini L, d Angelo M, Novelli R, Castelli V, Giorgio C, Sirico A, et al. Paclitaxel binds and activates C5aR1: A new potential therapeutic target for the prevention of chemotherapy-induced peripheral neuropathy and hypersensitivity reactions. Cell Death Dis. 2022;13:500 pubmed publisher |
Consonni F, Bleve A, Totaro M, Storto M, Kunderfranco P, Termanini A, et al. Heme catabolism by tumor-associated macrophages controls metastasis formation. Nat Immunol. 2021;22:595-606 pubmed publisher |
van den Bos E, Ambrosy B, Horsthemke M, Walbaum S, Bachg A, Wettschureck N, et al. Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor-mediated chemotaxis. J Biol Chem. 2020;295:7726-7742 pubmed publisher |
Schmider A, Bauer N, Sunwoo H, Godin M, Ellis G, Lee J, et al. Two- and three-color STORM analysis reveals higher-order assembly of leukotriene synthetic complexes on the nuclear envelope of murine neutrophils. J Biol Chem. 2020;295:5761-5770 pubmed publisher |
Hsu B, Roy J, Mouhanna J, Rayes R, Ramsay L, Tabariès S, et al. C3a elicits unique migratory responses in immature low-density neutrophils. Oncogene. 2020;39:2612-2623 pubmed publisher |
Muth C, Hartmann A, Sepulveda Falla D, Glatzel M, Krasemann S. Phagocytosis of Apoptotic Cells Is Specifically Upregulated in ApoE4 Expressing Microglia in vitro. Front Cell Neurosci. 2019;13:181 pubmed publisher |
Kobayakawa K, Ohkawa Y, Yoshizaki S, Tamaru T, Saito T, Kijima K, et al. Macrophage centripetal migration drives spontaneous healing process after spinal cord injury. Sci Adv. 2019;5:eaav5086 pubmed publisher |
Funk N, Munz M, Ott T, Brockmann K, Wenninger Weinzierl A, Kühn R, et al. The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4. Sci Rep. 2019;9:4515 pubmed publisher |
Arandjelovic S, Perry J, Lucas C, Penberthy K, Kim T, Zhou M, et al. A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis. Nat Immunol. 2019;20:141-151 pubmed publisher |
Crowley M, Delgado O, Will Orrego A, Buchanan N, Anderson K, Jaffee B, et al. Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models. Invest Ophthalmol Vis Sci. 2018;59:940-951 pubmed publisher |
Toomey C, Landowski M, Klingeborn M, Kelly U, Deans J, Dong H, et al. Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2018;59:662-673 pubmed publisher |
Herrmann J, Muenstermann M, Strobel L, Schubert Unkmeir A, Woodruff T, Gray Owen S, et al. Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease Treatment. MBio. 2018;9: pubmed publisher |
Syed S, Rau E, Ziegelmann M, Sogkas G, Brüne B, Schmidt R. C5aR activation in the absence of C5a: A new disease mechanism of autoimmune hemolytic anemia in mice. Eur J Immunol. 2018;48:696-704 pubmed publisher |
Wang Y, Lai P, Chen X, He C, Huang X, Geng S, et al. Attenuation of cGVHD by C5a/C5aR blockade is associated with increased frequency of Treg. Sci Rep. 2017;7:3603 pubmed publisher |
Bergdolt S, Kovtun A, Hägele Y, Liedert A, Schinke T, Amling M, et al. Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing. PLoS ONE. 2017;12:e0179512 pubmed publisher |
Markiewski M, Vadrevu S, Sharma S, Chintala N, Ghouse S, Cho J, et al. The Ribosomal Protein S19 Suppresses Antitumor Immune Responses via the Complement C5a Receptor 1. J Immunol. 2017;198:2989-2999 pubmed publisher |
Shutov L, Warwick C, Shi X, Gnanasekaran A, Shepherd A, Mohapatra D, et al. The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1. J Neurosci. 2016;36:5055-70 pubmed publisher |
Contractor T, Kobayashi S, da Silva E, Clausen R, Chan C, Vosburgh E, et al. Sexual dimorphism of liver metastasis by murine pancreatic neuroendocrine tumors is affected by expression of complement C5. Oncotarget. 2016;7:30585-96 pubmed publisher |
Hillgruber C, Pöppelmann B, Weishaupt C, Steingräber A, Wessel F, Berdel W, et al. Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopenia. J Exp Med. 2015;212:1255-66 pubmed publisher |
Yatime L, Maasch C, Hoehlig K, Klussmann S, Andersen G, Vater A. Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer. Nat Commun. 2015;6:6481 pubmed publisher |
Piao C, Cai L, Qiu S, Jia L, Song W, Du J. Complement 5a Enhances Hepatic Metastases of Colon Cancer via Monocyte Chemoattractant Protein-1-mediated Inflammatory Cell Infiltration. J Biol Chem. 2015;290:10667-76 pubmed publisher |
Price P, Bánki Z, Scheideler A, Stoiber H, Verschoor A, Sutter G, et al. Complement component C5 recruits neutrophils in the absence of C3 during respiratory infection with modified vaccinia virus Ankara. J Immunol. 2015;194:1164-8 pubmed publisher |
Pazos M, Pirzai W, Yonker L, Morisseau C, Gronert K, Hurley B. Distinct cellular sources of hepoxilin A3 and leukotriene B4 are used to coordinate bacterial-induced neutrophil transepithelial migration. J Immunol. 2015;194:1304-15 pubmed publisher |
Grailer J, Fattahi F, Dick R, Zetoune F, Ward P. Cutting edge: critical role for C5aRs in the development of septic lymphopenia in mice. J Immunol. 2015;194:868-72 pubmed publisher |
Vijayan S, Asare Y, Grommes J, Soehnlein O, Lutgens E, Shagdarsuren G, et al. High expression of C5L2 correlates with high proinflammatory cytokine expression in advanced human atherosclerotic plaques. Am J Pathol. 2014;184:2123-33 pubmed publisher |
Kim J, Oh S, Ahn S, Chung D. IFN-?-producing NKT cells exacerbate sepsis by enhancing C5a generation via IL-10-mediated inhibition of CD55 expression on neutrophils. Eur J Immunol. 2014;44:2025-35 pubmed publisher |
Hsu W, Yang F, Lin C, Hsieh S, Chen N. C5L2 is required for C5a-triggered receptor internalization and ERK signaling. Cell Signal. 2014;26:1409-19 pubmed publisher |
Bosmann M, Grailer J, Ruemmler R, Russkamp N, Zetoune F, Sarma J, et al. Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury. FASEB J. 2013;27:5010-21 pubmed publisher |
Hoehlig K, Maasch C, Shushakova N, Buchner K, Huber Lang M, Purschke W, et al. A novel C5a-neutralizing mirror-image (l-)aptamer prevents organ failure and improves survival in experimental sepsis. Mol Ther. 2013;21:2236-46 pubmed publisher |
Bosmann M, Haggadone M, Zetoune F, Sarma J, Ward P. The interaction between C5a and both C5aR and C5L2 receptors is required for production of G-CSF during acute inflammation. Eur J Immunol. 2013;43:1907-13 pubmed publisher |
Abe T, Hosur K, Hajishengallis E, Reis E, Ricklin D, Lambris J, et al. Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist. J Immunol. 2012;189:5442-8 pubmed publisher |
Gunn L, Ding C, Liu M, Ma Y, Qi C, Cai Y, et al. Opposing roles for complement component C5a in tumor progression and the tumor microenvironment. J Immunol. 2012;189:2985-94 pubmed publisher |
Heimbach L, Li Z, Berkowitz P, Zhao M, Li N, Rubenstein D, et al. The C5a receptor on mast cells is critical for the autoimmune skin-blistering disease bullous pemphigoid. J Biol Chem. 2011;286:15003-9 pubmed publisher |
Liang S, Krauss J, Domon H, McIntosh M, Hosur K, Qu H, et al. The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss. J Immunol. 2011;186:869-77 pubmed publisher |
Chen N, Mirtsos C, Suh D, Lu Y, Lin W, McKerlie C, et al. C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a. Nature. 2007;446:203-7 pubmed |
Zemann B, Urtz N, Reuschel R, Mechtcheriakova D, Bornancin F, Badegruber R, et al. Normal neutrophil functions in sphingosine kinase type 1 and 2 knockout mice. Immunol Lett. 2007;109:56-63 pubmed |
