Recombinant Human BAFF/BLyS/TNFSF13B Protein, CF | R&D Systems 2149-BF-010/CF product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human BAFF/BLyS/TNFSF13B Protein, CF

catalog :

2149-BF-010/CF

quantity :

10 ug (also 1 mg)

price :

276 USD

citations: 19

Reference
Kim J, Islam S, Qiao F, Singh A, Khan M, Won J, et al. Regulation of B cell functions by S-nitrosoglutathione in the EAE model. Redox Biol. 2021;45:102053 pubmed publisher
Mulazzani M, Huber M, Borchard S, Langer S, Angele B, Schuh E, et al. APRIL and BAFF: novel biomarkers for central nervous system lymphoma. J Hematol Oncol. 2019;12:102 pubmed publisher
Wilson R, Makuch M, Kienzler A, Varley J, Taylor J, Woodhall M, et al. Condition-dependent generation of aquaporin-4 antibodies from circulating B cells in neuromyelitis optica. Brain. 2018;141:1063-1074 pubmed publisher
Clarke A, Poulton L, Shim D, Mabon D, Butt D, Pollard M, et al. An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease. MAbs. 2018;10:664-677 pubmed publisher
Heremans J, Garcia Perez J, Turro E, Schlenner S, Casteels I, Collin R, et al. Abnormal differentiation of B cells and megakaryocytes in patients with Roifman syndrome. J Allergy Clin Immunol. 2018;142:630-646 pubmed publisher
Brightbill H, Suto E, Blaquiere N, Ramamoorthi N, Sujatha Bhaskar S, Gogol E, et al. NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus. Nat Commun. 2018;9:179 pubmed publisher
Brach D, Johnston Blackwell D, Drew A, Lingaraj T, Motwani V, Warholic N, et al. EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL. Mol Cancer Ther. 2017;16:2586-2597 pubmed publisher
Sindhava V, Oropallo M, Moody K, Naradikian M, Higdon L, Zhou L, et al. A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens. J Clin Invest. 2017;127:1651-1663 pubmed publisher
Mamara A, Germenis A, Kompoti M, Palassopoulou M, Mandala E, Banti A, et al. TACI expression and signaling in chronic lymphocytic leukemia. J Immunol Res. 2015;2015:478753 pubmed publisher
Chinen Y, Kuroda J, Shimura Y, Nagoshi H, Kiyota M, Yamamoto Sugitani M, et al. Phosphoinositide protein kinase PDPK1 is a crucial cell signaling mediator in multiple myeloma. Cancer Res. 2014;74:7418-29 pubmed publisher
Caro Maldonado A, Wang R, Nichols A, Kuraoka M, Milasta S, Sun L, et al. Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol. 2014;192:3626-36 pubmed publisher
Deknuydt F, Nordstrom T, Riesbeck K. Diversion of the host humoral response: a novel virulence mechanism of Haemophilus influenzae mediated via outer membrane vesicles. J Leukoc Biol. 2014;95:983-91 pubmed publisher
Sahaf B, Yang Y, Arai S, Herzenberg L, Herzenberg L, Miklos D. H-Y antigen-binding B cells develop in male recipients of female hematopoietic cells and associate with chronic graft vs. host disease. Proc Natl Acad Sci U S A. 2013;110:3005-10 pubmed publisher
Negro R, Gobessi S, Longo P, He Y, Zhang Z, Laurenti L, et al. Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT. Blood. 2012;119:6278-87 pubmed publisher
Zhu J, Sun L, Lin S, Zhao R, Zhou L, Fang D, et al. BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells. J Exp Clin Cancer Res. 2012;31:31 pubmed publisher
Bloom D, Chang Z, Pauly K, Kwun J, Fechner J, Hayes C, et al. BAFF is increased in renal transplant patients following treatment with alemtuzumab. Am J Transplant. 2009;9:1835-45 pubmed publisher
Neri P, Kumar S, Fulciniti M, Vallet S, Chhetri S, Mukherjee S, et al. Neutralizing B-cell activating factor antibody improves survival and inhibits osteoclastogenesis in a severe combined immunodeficient human multiple myeloma model. Clin Cancer Res. 2007;13:5903-9 pubmed
Kaur K, Chowdhury S, Greenspan N, Schreiber J. Decreased expression of tumor necrosis factor family receptors involved in humoral immune responses in preterm neonates. Blood. 2007;110:2948-54 pubmed
Ettinger R, Sims G, Robbins R, Withers D, Fischer R, Grammer A, et al. IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells. J Immunol. 2007;178:2872-82 pubmed

product information

brand :

R&D Systems, a Bio-Techne brand

catalog number base :

2149-BF/CF

SKU :

2149-BF-010/CF

product name :

Recombinant Human BAFF/BLyS/TNFSF13B Protein, CF

description :

The Recombinant Human BAFF/BLyS/TNFSF13B Protein, CF from R&D Systems is derived from NS0. The Recombinant Human BAFF/BLyS/TNFSF13B Protein, CF has been validated for the following applications: Bioactivity.

target :

BAFF/BLyS/TNFSF13B

unit size :

10 ug (also 1 mg)

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS, EDTA and DTT.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

observed molecular weight :

22-29 kDa, reducing conditions

theoretical molecular weight :

19.6 kDa

gene symbol :

TNFSF13B

details of functionality :

Measured in a cell proliferation assay using anti-IgM stimulated mouse B cells. The ED50 for this effect is 0.4-2 ng/mL in the presence of goat anti-mouse IgM µ chain.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q9Y275.1

applications :

Bioactivity

product keywords :

2149-BF, rhBAFF/BLyS, hBAFF, carrier-free, carrier free, 2149BF/CF, cytokinegrowthfact, TNFSF 13B, cytokine, cytokines, sCD257, sBAFF, TNFSFCoReg

source :

NS0-derived Recombinant Human BAFF/BLyS/TNFSF13B Protein, CF

extended description :

Soon to be discontinued.

USD :

273

USD 2025 :

276 USD

product details :

Soon to be discontinued.

alt names :

ApoL related ligand TALL-1, B lymphocyte stimulator, BAFFB-cell activating factor, B-cell-activating factor, BLyS, BLYSB-lymphocyte stimulator, CD257, CD257 antigen, Dendritic cell-derived TNF-like molecule, DTL, TALL1, TALL-1delta BAFF, TALL1Delta4 BAFF, THANK, TNF and ApoL-related leukocyte expressed ligand 1, TNF- and APOL-related leukocyte expressed ligand 1, TNF homolog that activates apoptosis, TNFSF13B, TNFSF20, tumor necrosis factor (ligand) superfamily, member 13b, tumor necrosis factor (ligand) superfamily, member 20, tumor necrosis factor ligand superfamily member 13B, tumor necrosis factor superfamily, member 13b, tumor necrosis factor-like protein ZTNF4, ZTNF4