product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human LDLR Protein, CF
catalog :
2148-LD-025/CF
quantity :
25 ug
price :
443 USD
more info or order :
R&D Systems product webpage
citations: 9
Reference
Masuda Y, Yamaguchi S, Suzuki C, Aburatani T, Nagano Y, Miyauchi R, et al. Generation and Characterization of a Novel Small Biologic Alternative to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Antibodies, DS-9001a, Albumin Binding Domain-Fused Anticalin Protein. J Pharmacol Exp Ther. 2018;365:368-378 pubmed publisher
Felt S, Droby G, Grdzelishvili V. Ruxolitinib and Polycation Combination Treatment Overcomes Multiple Mechanisms of Resistance of Pancreatic Cancer Cells to Oncolytic Vesicular Stomatitis Virus. J Virol. 2017;91: pubmed publisher
Kraehling J, Chidlow J, Rajagopal C, Sugiyama M, Fowler J, Lee M, et al. Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells. Nat Commun. 2016;7:13516 pubmed publisher
Amirache F, Levy C, Costa C, Mangeot P, Torbett B, Wang C, et al. Mystery solved: VSV-G-LVs do not allow efficient gene transfer into unstimulated T cells, B cells, and HSCs because they lack the LDL receptor. Blood. 2014;123:1422-4 pubmed publisher
Kurasawa J, Shestopal S, Karnaukhova E, Struble E, Lee T, Sarafanov A. Mapping the binding region on the low density lipoprotein receptor for blood coagulation factor VIII. J Biol Chem. 2013;288:22033-41 pubmed publisher
DeVay R, Shelton D, Liang H. Characterization of proprotein convertase subtilisin/kexin type 9 (PCSK9) trafficking reveals a novel lysosomal targeting mechanism via amyloid precursor-like protein 2 (APLP2). J Biol Chem. 2013;288:10805-18 pubmed publisher
Duff C, Scott M, Kirby I, Hutchinson S, Martin S, Hooper N. Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor. Biochem J. 2009;419:577-84 pubmed publisher
Chien Y, Chen W, Hsu W, Chiou S. Bovine lactoferrin inhibits Japanese encephalitis virus by binding to heparan sulfate and receptor for low density lipoprotein. Virology. 2008;379:143-51 pubmed publisher
Fisher T, Lo Surdo P, Pandit S, Mattu M, Santoro J, Wisniewski D, et al. Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation. J Biol Chem. 2007;282:20502-12 pubmed
product information
master code :
2148-LD/CF
SKU :
2148-LD-025/CF
product name :
Recombinant Human LDLR Protein, CF
unit size :
25 ug
description :
The Recombinant Human LDLR Protein, CF from R&D Systems is derived from NS0. The Recombinant Human LDLR Protein, CF has been validated for the following applications: Bioactivity.
target :
LDLR
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
125-140 kDa 95-110 kDa, reducing conditions
theoretical molecular weight :
85.6 kDa 66.8 kDa
gene symbol :
LDLR
details of functionality :
Measured in a competitive binding assay. When human LDL is immobilized at 1 ╡g/mL (100 ╡L/well), Recombinant Human LDL R inhibits 50% binding of biotinylated recombinant human LDL R (0.5 ╡g/mL) at the concentration range of 0.4-2 ╡g/mL
endotoxin note :
<0.1 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q59FQ1
applications :
Bioactivity
source long :
Mouse myeloma cell line, NS0-derived human LDL R protein Ala22-Arg788, with a C-terminal 6-His tag
source short :
NS0
USD :
443 USD
alt names :
FH, FHC, LDL R, LDL receptor, LDLCQ2, low density lipoprotein receptor, low-density lipoprotein receptor, low-density lipoprotein receptor class A domain-containing protein 3
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.