Recombinant Human GDNF GMP Protein, CF | R&D Systems 212-GMP-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human GDNF GMP Protein, CF

catalog :

212-GMP-010

quantity :

10 ug (also 1 mg, 50 ug)

price :

548 USD

more info or order :

R&D Systems product webpage

citations: 1

Reference
Piao J, Zabierowski S, Dubose B, Hill E, Navare M, Claros N, et al. Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01. Cell Stem Cell. 2021;28:217-229.e7 pubmed publisher

image

image 1 :

Recombinant Human GDNF GMP Protein Bioactivity

product information

brand :

R&D Systems

master code :

212-GMP

SKU :

212-GMP-010

product name :

Recombinant Human GDNF GMP Protein, CF

description :

The Recombinant Human GDNF GMP Protein, CF from R&D Systems is derived from NS0. The Recombinant Human GDNF GMP Protein, CF has been validated for the following applications: Bioactivity.

target :

GDNF

category :

Proteins and Enzymes

sizes available :

10 ug (also 1 mg, 50 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE with silver staining, under reducing conditions.

species :

Human

theoretical molecular weight :

11.6 kDa (monomer)

gene symbol :

GDNF

details of functionality :

Measured in a cell proliferation assay using SH-SY5Y human neuroblastoma cells. The ED50 for this effect is 2-12 ng/mL in the presence of Recombinant Human GFR alpha-1/GDNF R alpha-1 Fc Chimera (Catalog # 714-GR ). The specific activity of recombinant human GDNF is 5.0 x 105 units/mg, which is calibrated against the human GDNF Reference Standard (NIBSC code: 09/266). Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human GFR alpha-1/GDNF R alpha-1 Fc Chimera (Catalog # 714-GR ) at 1 µg/mL can bind Recombinant Human GDNF with an apparent Kd 1 nM.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P39905.1

applications :

Bioactivity

source :

NS0-derived Recombinant Human GDNF GMP Protein, CF

USD :

522

USD 2023 :

548 USD

alt names :

Astrocyte-derived trophic factor, ATF, ATF1, ATF2, glial cell derived neurotrophic factor, glial cell line derived neurotrophic factor, glial cell line-derived neurotrophic factor, HFB1-GDNF, HGDNF, HSCR3

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. A minimum of 12 months when stored at <= -20 °C as supplied. Refer to lot specific COA for the Use by Date. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, <= -20 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage