This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human GDNF Protein
catalog :
212-GD
quantity :
10 ug (also 50 ug, 1 mg)
price :
299 USD
citations: 108
Reference
Kielkowski P, Buchsbaum I, Kirsch V, Bach N, Drukker M, Cappello S, et al. FICD activity and AMPylation remodelling modulate human neurogenesis. Nat Commun. 2020;11:517 pubmed publisher
Nickolls A, Lee M, Espinoza D, Szczot M, Lam R, Wang Q, et al. Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells. Cell Rep. 2020;30:932-946.e7 pubmed publisher
Munezane H, Oizumi H, Wakabayashi T, Nishio S, Hirasawa T, Sato T, et al. Roles of Collagen XXV and Its Putative Receptors PTPσ/δ in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder. Cell Rep. 2019;29:4362-4376.e6 pubmed publisher
Bonafina A, Trinchero M, Ríos A, Bekinschtein P, SCHINDER A, Paratcha G, et al. GDNF and GFRα1 Are Required for Proper Integration of Adult-Born Hippocampal Neurons. Cell Rep. 2019;29:4308-4319.e4 pubmed publisher
Chumarina M, Russ K, Azevedo C, Heuer A, Pihl M, Collin A, et al. Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene. Acta Neuropathol Commun. 2019;7:208 pubmed publisher
Mahajani S, Raina A, Fokken C, Kügler S, Bahr M. Homogenous generation of dopaminergic neurons from multiple hiPSC lines by transient expression of transcription factors. Cell Death Dis. 2019;10:898 pubmed publisher
Hyvärinen T, Hyysalo A, Kapucu F, Aarnos L, Vinogradov A, Eglen S, et al. Functional characterization of human pluripotent stem cell-derived cortical networks differentiated on laminin-521 substrate: comparison to rat cortical cultures. Sci Rep. 2019;9:17125 pubmed publisher
Leitner D, Ramamoorthy M, Dejosez M, Zwaka T. Immature mDA neurons ameliorate motor deficits in a 6-OHDA Parkinson's disease mouse model and are functional after cryopreservation. Stem Cell Res. 2019;41:101617 pubmed publisher
Larsen H, Hansen S, Mikkelsen J, Hyttel P, Stummann T. Alpha7 nicotinic acetylcholine receptors and neural network synaptic transmission in human induced pluripotent stem cell-derived neurons. Stem Cell Res. 2019;41:101642 pubmed publisher
De Luzy I, Niclis J, Gantner C, Kauhausen J, Hunt C, Ermine C, et al. Isolation of LMX1a Ventral Midbrain Progenitors Improves the Safety and Predictability of Human Pluripotent Stem Cell-Derived Neural Transplants in Parkinsonian Disease. J Neurosci. 2019;39:9521-9531 pubmed publisher
Butts J, Iyer N, White N, THOMPSON R, Sakiyama Elbert S, McDevitt T. V2a interneuron differentiation from mouse and human pluripotent stem cells. Nat Protoc. 2019;14:3033-3058 pubmed publisher
Luo J, Xia Y, Yin Y, Luo J, Liu M, Zhang H, et al. ATF4 destabilizes RET through nonclassical GRP78 inhibition to enhance chemosensitivity to bortezomib in human osteosarcoma. Theranostics. 2019;9:6334-6353 pubmed publisher
Lin C, Yoshida M, Li L, Ikenaka A, Oshima S, Nakagawa K, et al. iPSC-derived functional human neuromuscular junctions model the pathophysiology of neuromuscular diseases. JCI Insight. 2019;4: pubmed publisher
Babos K, Galloway K, Kisler K, Zitting M, Li Y, Shi Y, et al. Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming. Cell Stem Cell. 2019;25:486-500.e9 pubmed publisher
Cholewa Waclaw J, Shah R, Webb S, Chhatbar K, Ramsahoye B, Pusch O, et al. Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic. Proc Natl Acad Sci U S A. 2019;116:14995-15000 pubmed publisher
Yang H, Hao D, Liu C, Huang D, Chen B, Fan H, et al. Generation of functional dopaminergic neurons from human spermatogonial stem cells to rescue parkinsonian phenotypes. Stem Cell Res Ther. 2019;10:195 pubmed publisher
Ryynänen T, Pelkonen A, Grigoras K, Ylivaara O, Hyvärinen T, Ahopelto J, et al. Microelectrode Array With Transparent ALD TiN Electrodes. Front Neurosci. 2019;13:226 pubmed publisher
Elkouris M, Kouroupi G, Vourvoukelis A, Papagiannakis N, Kaltezioti V, Matsas R, et al. Long Non-coding RNAs Associated With Neurodegeneration-Linked Genes Are Reduced in Parkinson's Disease Patients. Front Cell Neurosci. 2019;13:58 pubmed publisher
Ooi J, Langley S, Xu X, Utami K, Sim B, Huang Y, et al. Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects. Cell Rep. 2019;26:2494-2508.e7 pubmed publisher
Gong J, Szego E, Leonov A, Benito E, Becker S, Fischer A, et al. Translocator Protein Ligand Protects against Neurodegeneration in the MPTP Mouse Model of Parkinsonism. J Neurosci. 2019;39:3752-3769 pubmed publisher
Wu M, Ma L, Xue L, Ye W, Lu Z, Li X, et al. Resveratrol alleviates chemotherapy-induced oogonial stem cell apoptosis and ovarian aging in mice. Aging (Albany NY). 2019;11:1030-1044 pubmed publisher
Iwasawa C, Kuzumaki N, Suda Y, Kagawa R, Oka Y, Hattori N, et al. Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations. Mol Brain. 2019;12:5 pubmed publisher
Melamed Z, López Erauskin J, Baughn M, Zhang O, Drenner K, Sun Y, et al. Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration. Nat Neurosci. 2019;22:180-190 pubmed publisher
Klim J, Williams L, Limone F, Guerra San Juan I, Davis Dusenbery B, Mordes D, et al. ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair. Nat Neurosci. 2019;22:167-179 pubmed publisher
Edwards T, Bloom D. Lund Human Mesencephalic (LUHMES) Neuronal Cell Line Supports Herpes Simplex Virus 1 Latency In Vitro. J Virol. 2019;93: pubmed publisher
Gutbier S, Spreng A, Delp J, Schildknecht S, Karreman C, Suciu I, et al. Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress. Cell Death Differ. 2018;25:2101-2117 pubmed publisher
Kirino K, Nakahata T, Taguchi T, Saito M. Efficient derivation of sympathetic neurons from human pluripotent stem cells with a defined condition. Sci Rep. 2018;8:12865 pubmed publisher
Fujimori K, Ishikawa M, Otomo A, Atsuta N, Nakamura R, Akiyama T, et al. Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent. Nat Med. 2018;24:1579-1589 pubmed publisher
Koyuncu S, Saez I, Lee H, Gutiérrez García R, Pokrzywa W, Fatima A, et al. The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients. Nat Commun. 2018;9:2886 pubmed publisher
Tsuburaya N, Homma K, Higuchi T, Balia A, Yamakoshi H, Shibata N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018;9:2668 pubmed publisher
Yehuda Y, Blumenfeld B, Mayorek N, Makedonski K, Vardi O, Cohen Daniel L, et al. Germline DNA replication timing shapes mammalian genome composition. Nucleic Acids Res. 2018;46:8299-8310 pubmed publisher
Collo G, Cavalleri L, Zoli M, Maskos U, Ratti E, Merlo Pich E. Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons. Front Pharmacol. 2018;9:572 pubmed publisher
Nehme R, Zuccaro E, Ghosh S, Li C, Sherwood J, Pietiläinen O, et al. Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission. Cell Rep. 2018;23:2509-2523 pubmed publisher
Kakiuchi K, Taniguchi K, Kubota H. Conserved and non-conserved characteristics of porcine glial cell line-derived neurotrophic factor expressed in the testis. Sci Rep. 2018;8:7656 pubmed publisher
Ziller M, Ortega J, Quinlan K, Santos D, Gu H, Martin E, et al. Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology. Cell Stem Cell. 2018;22:559-574.e9 pubmed publisher
Collo G, Cavalleri L, Bono F, Mora C, Fedele S, Invernizzi R, et al. Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling. Neural Plast. 2018;2018:4196961 pubmed publisher
Jalili R, Horecka J, Swartz J, Davis R, Persson H. Streamlined circular proximity ligation assay provides high stringency and compatibility with low-affinity antibodies. Proc Natl Acad Sci U S A. 2018;115:E925-E933 pubmed publisher
Silvestris E, Cafforio P, D Oronzo S, Felici C, Silvestris F, Loverro G. In vitro differentiation of human oocyte-like cells from oogonial stem cells: single-cell isolation and molecular characterization. Hum Reprod. 2018;33:464-473 pubmed publisher
Edwards T, Bloom D, Fisher C. The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication. J Virol. 2018;92: pubmed publisher
Avaliani N, Pfisterer U, Heuer A, Parmar M, Kokaia M, Andersson M. Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus. Stem Cells Int. 2017;2017:5718608 pubmed publisher
Newman E, Chukkapalli S, Bashllari D, Thomas T, Van Noord R, Lawlor E, et al. Alternative NHEJ pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation: implications for neuroblastoma initiation. Cell Death Dis. 2017;8:3208 pubmed publisher
Awad O, Panicker L, Deranieh R, Srikanth M, Brown R, Voit A, et al. Altered Differentiation Potential of Gaucher's Disease iPSC Neuronal Progenitors due to Wnt/?-Catenin Downregulation. Stem Cell Reports. 2017;9:1853-1867 pubmed publisher
Ruetz T, Pfisterer U, Di Stefano B, Ashmore J, Beniazza M, Tian T, et al. Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming. Cell Stem Cell. 2017;21:791-805.e9 pubmed publisher
Taguchi A, Nishinakamura R. Higher-Order Kidney Organogenesis from Pluripotent Stem Cells. Cell Stem Cell. 2017;21:730-746.e6 pubmed publisher
Ferreira M, Boens S, Winkler C, Szekér K, Verbinnen I, Van Eynde A, et al. The protein phosphatase 1 regulator NIPP1 is essential for mammalian spermatogenesis. Sci Rep. 2017;7:13364 pubmed publisher
Höllerhage M, Moebius C, Melms J, Chiu W, Goebel J, Chakroun T, et al. Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells. Sci Rep. 2017;7:11469 pubmed publisher
Liu J, Shang D, Xiao Y, Zhong P, Cheng H, Zhou R. Isolation and characterization of string-forming female germline stem cells from ovaries of neonatal mice. J Biol Chem. 2017;292:16003-16013 pubmed publisher
Drouin Ouellet J, Lau S, Brattås P, Rylander Ottosson D, Pircs K, Grassi D, et al. REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways. EMBO Mol Med. 2017;9:1117-1131 pubmed publisher
Park H, Bolton E. RET-mediated glial cell line-derived neurotrophic factor signaling inhibits mouse prostate development. Development. 2017;144:2282-2293 pubmed publisher
Gassei K, Sheng Y, Fayomi A, Mital P, Sukhwani M, Lin C, et al. DDX4-EGFP transgenic rat model for the study of germline development and spermatogenesis. Biol Reprod. 2017;96:707-719 pubmed publisher
Dong G, Shang Z, Liu L, Liu C, Ge Y, Wang Q, et al. Retinoic acid combined with spermatogonial stem cell conditions facilitate the generation of mouse germ-like cells. Biosci Rep. 2017;37: pubmed publisher
Niclis J, Gantner C, Alsanie W, McDougall S, Bye C, Elefanty A, et al. Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents. Stem Cells Transl Med. 2017;6:937-948 pubmed publisher
Gat I, Maghen L, Filice M, Wyse B, Zohni K, Jarvi K, et al. Optimal culture conditions are critical for efficient expansion of human testicular somatic and germ cells in vitro. Fertil Steril. 2017;107:595-605.e7 pubmed publisher
Sambi M, Chow T, Whiteley J, Li M, Chua S, Raileanu V, et al. Acellular Mouse Kidney ECM can be Used as a Three-Dimensional Substrate to Test the Differentiation Potential of Embryonic Stem Cell Derived Renal Progenitors. Stem Cell Rev. 2017;13:513-531 pubmed publisher
Menges S, Minakaki G, Schaefer P, Meixner H, Prots I, Schlötzer Schrehardt U, et al. Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress. Sci Rep. 2017;7:42942 pubmed publisher
Goparaju S, Kohda K, Ibata K, Soma A, Nakatake Y, Akiyama T, et al. Rapid differentiation of human pluripotent stem cells into functional neurons by mRNAs encoding transcription factors. Sci Rep. 2017;7:42367 pubmed publisher
Boland M, Nazor K, Tran H, Szucs A, Lynch C, Paredes R, et al. Molecular analyses of neurogenic defects in a human pluripotent stem cell model of fragile X syndrome. Brain. 2017;140:582-598 pubmed publisher
Liddelow S, Guttenplan K, Clarke L, Bennett F, Bohlen C, Schirmer L, et al. Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017;541:481-487 pubmed publisher
Zhao Z, Ma Y, Chen Z, Liu Q, Li Q, Kong D, et al. Effects of Feeder Cells on Dopaminergic Differentiation of Human Embryonic Stem Cells. Front Cell Neurosci. 2016;10:291 pubmed publisher
Armijo E, Gonzalez C, Shahnawaz M, Flores A, Davis B, Soto C. Increased susceptibility to A? toxicity in neuronal cultures derived from familial Alzheimer's disease (PSEN1-A246E) induced pluripotent stem cells. Neurosci Lett. 2017;639:74-81 pubmed publisher
Jiang P, Gan M, Yen S, McLean P, Dickson D. Histones facilitate α-synuclein aggregation during neuronal apoptosis. Acta Neuropathol. 2017;133:547-558 pubmed publisher
Varun D, Srinivasan G, Tsai Y, Kim H, Cutts J, Petty F, et al. A robust vitronectin-derived peptide for the scalable long-term expansion and neuronal differentiation of human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs). Acta Biomater. 2017;48:120-130 pubmed publisher
Pfisterer U, Ek F, Lang S, Soneji S, Olsson R, Parmar M. Small molecules increase direct neural conversion of human fibroblasts. Sci Rep. 2016;6:38290 pubmed publisher
Kuijlaars J, Oyelami T, Diels A, Rohrbacher J, Versweyveld S, Meneghello G, et al. Sustained synchronized neuronal network activity in a human astrocyte co-culture system. Sci Rep. 2016;6:36529 pubmed publisher
Toyoshima M, Akamatsu W, Okada Y, Ohnishi T, Balan S, Hisano Y, et al. Analysis of induced pluripotent stem cells carrying 22q11.2 deletion. Transl Psychiatry. 2016;6:e934 pubmed publisher
Parr C, Katayama S, Miki K, Kuang Y, Yoshida Y, Morizane A, et al. MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells. Sci Rep. 2016;6:32532 pubmed publisher
Bayarsaikhan E, Bayarsaikhan D, Lee J, Son M, Oh S, Moon J, et al. Microglial AGE-albumin is critical for neuronal death in Parkinson's disease: a possible implication for theranostics. Int J Nanomedicine. 2015;10 Spec Iss:281-92 pubmed publisher
Sato H, Idiris A, Miwa T, Kumagai H. Microfabric Vessels for Embryoid Body Formation and Rapid Differentiation of Pluripotent Stem Cells. Sci Rep. 2016;6:31063 pubmed publisher
Sun Y, Paşca S, Portmann T, Goold C, Worringer K, Guan W, et al. A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients. elife. 2016;5: pubmed publisher
Pinho R, Guedes L, Soreq L, Lobo P, Mestre T, Coelho M, et al. Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles. PLoS ONE. 2016;11:e0157852 pubmed publisher
Gho C, Schomann T, de Groot S, Frijns J, Rivolta M, Neumann M, et al. Isolation, expansion and neural differentiation of stem cells from human plucked hair: a further step towards autologous nerve recovery. Cytotechnology. 2016;68:1849-58 pubmed publisher
Jonas R, Klusch A, Schmelz M, Petersen M, Carr R. Assessment of TTX-s and TTX-r Action Potential Conduction along Neurites of NGF and GDNF Cultured Porcine DRG Somata. PLoS ONE. 2015;10:e0139107 pubmed publisher
Lim M, Shin M, Lee S, Minn Y, Hoh J, Cho Y, et al. Noggin Over-Expressing Mouse Embryonic Fibroblasts and MS5 Stromal Cells Enhance Directed Differentiation of Dopaminergic Neurons from Human Embryonic Stem Cells. PLoS ONE. 2015;10:e0138460 pubmed publisher
Laguna A, Schintu N, Nobre A, Alvarsson A, Volakakis N, Jacobsen J, et al. Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease. Nat Neurosci. 2015;18:826-35 pubmed publisher
Merkle F, MAROOF A, Wataya T, Sasai Y, Studer L, Eggan K, et al. Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells. Development. 2015;142:633-43 pubmed publisher
Chen X, Wales P, Quinti L, Zuo F, Moniot S, Herisson F, et al. The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia. PLoS ONE. 2015;10:e0116919 pubmed publisher
Devlin A, Burr K, Borooah S, Foster J, Cleary E, Geti I, et al. Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability. Nat Commun. 2015;6:5999 pubmed publisher
Jin H, Kanthasamy A, Harischandra D, Kondru N, Ghosh A, Panicker N, et al. Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease. J Biol Chem. 2014;289:34743-67 pubmed publisher
Pereira M, Pfisterer U, Rylander D, Torper O, Lau S, Lundblad M, et al. Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain. Sci Rep. 2014;4:6330 pubmed publisher
Weng M, Natarajan K, Scholz D, Ivanova V, Sachinidis A, Hengstler J, et al. Lineage-specific regulation of epigenetic modifier genes in human liver and brain. PLoS ONE. 2014;9:e102035 pubmed publisher
Peng L, Adler M, Demogines A, Borrell A, Liu H, Tao L, et al. Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins. PLoS Pathog. 2014;10:e1004177 pubmed publisher
Wang T, Bruggeman K, Sheean R, Turner B, Nisbet D, Parish C. Characterization of the stability and bio-functionality of tethered proteins on bioengineered scaffolds: implications for stem cell biology and tissue repair. J Biol Chem. 2014;289:15044-51 pubmed publisher
Doers M, Musser M, Nichol R, Berndt E, Baker M, Gomez T, et al. iPSC-derived forebrain neurons from FXS individuals show defects in initial neurite outgrowth. Stem Cells Dev. 2014;23:1777-87 pubmed publisher
Kales S, Nau M, Merchant A, Lipkowitz S. Enigma prevents Cbl-c-mediated ubiquitination and degradation of RETMEN2A. PLoS ONE. 2014;9:e87116 pubmed publisher
Zou Q, Yan Q, Zhong J, Wang K, Sun H, Yi X, et al. Direct conversion of human fibroblasts into neuronal restricted progenitors. J Biol Chem. 2014;289:5250-60 pubmed publisher
Hasegawa K, Namekawa S, Saga Y. MEK/ERK signaling directly and indirectly contributes to the cyclical self-renewal of spermatogonial stem cells. Stem Cells. 2013;31:2517-27 pubmed publisher
Quintino L, Manfre G, Wettergren E, Namislo A, Isaksson C, Lundberg C. Functional neuroprotection and efficient regulation of GDNF using destabilizing domains in a rodent model of Parkinson's disease. Mol Ther. 2013;21:2169-80 pubmed publisher
Prots I, Veber V, Brey S, Campioni S, Buder K, Riek R, et al. ?-Synuclein oligomers impair neuronal microtubule-kinesin interplay. J Biol Chem. 2013;288:21742-54 pubmed publisher
Higurashi N, Uchida T, Lossin C, Misumi Y, Okada Y, Akamatsu W, et al. A human Dravet syndrome model from patient induced pluripotent stem cells. Mol Brain. 2013;6:19 pubmed publisher
Yang Y, Gupta S, Kim K, Powers B, Cerqueira A, Wainger B, et al. A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell. 2013;12:713-26 pubmed publisher
Woods D, Tilly J. Isolation, characterization and propagation of mitotically active germ cells from adult mouse and human ovaries. Nat Protoc. 2013;8:966-88 pubmed publisher
Stappert L, Borghese L, Roese Koerner B, Weinhold S, Koch P, Terstegge S, et al. MicroRNA-based promotion of human neuronal differentiation and subtype specification. PLoS ONE. 2013;8:e59011 pubmed publisher
Luo Y, Tsuchiya K, Il Park D, Fausel R, Kanngurn S, Welcsh P, et al. RET is a potential tumor suppressor gene in colorectal cancer. Oncogene. 2013;32:2037-47 pubmed publisher
Lundgren T, Nakahata K, Fritz N, Rebellato P, Zhang S, Uhlen P. RET PLC? phosphotyrosine binding domain regulates Ca2+ signaling and neocortical neuronal migration. PLoS ONE. 2012;7:e31258 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Kubota H, Wu X, Goodyear S, Avarbock M, Brinster R. Glial cell line-derived neurotrophic factor and endothelial cells promote self-renewal of rabbit germ cells with spermatogonial stem cell properties. FASEB J. 2011;25:2604-14 pubmed publisher
Hadaczek P, Johnston L, Forsayeth J, Bankiewicz K. Pharmacokinetics and bioactivity of glial cell line-derived factor (GDNF) and neurturin (NTN) infused into the rat brain. Neuropharmacology. 2010;58:1114-21 pubmed publisher
Wang Y, Wu Y, Huang H, Lin H, Lo L, Tzeng S, et al. Sustained intraspinal delivery of neurotrophic factor encapsulated in biodegradable nanoparticles following contusive spinal cord injury. Biomaterials. 2008;29:4546-53 pubmed publisher
Lu B, PereiraPerrin M. A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruzi. Infect Immun. 2008;76:3530-8 pubmed publisher
Ladewig J, Koch P, Endl E, Meiners B, Opitz T, Couillard Despres S, et al. Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons. Stem Cells. 2008;26:1705-12 pubmed publisher
Ai X, Kitazawa T, Do A, Kusche Gullberg M, Labosky P, Emerson C. SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation. Development. 2007;134:3327-38 pubmed
Pankratz M, Li X, LaVaute T, Lyons E, Chen X, Zhang S. Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage. Stem Cells. 2007;25:1511-20 pubmed
Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, et al. Multipotent adult progenitor cells from swine bone marrow. Stem Cells. 2006;24:2355-66 pubmed
Nagy N, Goldstein A. Endothelin-3 regulates neural crest cell proliferation and differentiation in the hindgut enteric nervous system. Dev Biol. 2006;293:203-17 pubmed
Girard B, Young B, Buttolph T, Locknar S, White S, Parsons R. Trophic factor modulation of cocaine- and amphetamine-regulated transcript peptide expression in explant cultured guinea-pig cardiac neurons. Neuroscience. 2006;139:1329-41 pubmed
Castelo Branco G, Sousa K, Bryja V, Pinto L, Wagner J, Arenas E. Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion. Mol Cell Neurosci. 2006;31:251-62 pubmed
Perrier A, Tabar V, Barberi T, Rubio M, Bruses J, Topf N, et al. Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc Natl Acad Sci U S A. 2004;101:12543-8 pubmed
Esper R, Loeb J. Rapid axoglial signaling mediated by neuregulin and neurotrophic factors. J Neurosci. 2004;24:6218-27 pubmed
product information
brand :
R&D Systems
master code :
212-GD
SKU :
212-GD-010
product name :
Recombinant Human GDNF Protein
description :
The Recombinant Human GDNF Protein from R&D Systems is derived from NS0. The Recombinant Human GDNF Protein has been validated for the following applications: Bioactivity, Binding Activity.
target :
GDNF
category :
Proteins and Enzymes
unit size :
10 ug (also 50 ug, 1 mg)
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
theoretical molecular weight :
11.6 kDa (monomer)
gene symbol :
GDNF
details of functionality :
Measured in a cell proliferation assay using SH-SY5Y human neuroblastoma cells. The ED50 for this effect is 2-12 ng/mL in the presence of Recombinant Human GFR alpha-1/GDNF R alpha-1 Fc Chimera (Catalog # 714-GR ). The specific activity of recombinant human GDNF is approximately 3.1 x 103 units/µg, which is calibrated against recombinant human GDNF Reference Standard (NIBSC code: 09/266). Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human GFR alpha-1/GDNF R alpha-1 Fc Chimera (Catalog # 714-GR ) at 1 µg/mL can bind Recombinant Human GDNF with an apparent Kd 1 nM.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
catalog number base :
212-GD
accessionNumbers :
P39905
applications :
Bioactivity, Binding Activity
source :
Mouse myeloma cell line, NS0-derived human GDNF protein Arg109-Ile211
2020 USD :
299
2021 USD :
299 USD
alt names :
Astrocyte-derived trophic factor, ATF, ATF1, ATF2, glial cell derived neurotrophic factor, glial cell line derived neurotrophic factor, glial cell line-derived neurotrophic factor, HFB1-GDNF, HGDNF, HSCR3
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.