Human IFN-alpha Antibody | R&D Systems 21100-1 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IFN-alpha Antibody

catalog :

21100-1

quantity :

50 ug

price :

449 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MMHA-2

reactivity :

human

application :

western blot, ELISA, neutralization, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 13

Reference
Gervais A, Rovida F, Avanzini M, Croce S, Marchal A, Lin S, et al. Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients. J Exp Med. 2023;220: pubmed publisher
Hong J, Lee J, Zhang Z, Wu Y, Yang M, Liao Y, et al. PRC2-Mediated Epigenetic Suppression of Type I IFN-STAT2 Signaling Impairs Antitumor Immunity in Luminal Breast Cancer. Cancer Res. 2022;82:4624-4640 pubmed publisher
Zhang Q, Pizzorno A, Miorin L, Bastard P, Gervais A, Le Voyer T, et al. Autoantibodies against type I IFNs in patients with critical influenza pneumonia. J Exp Med. 2022;219: pubmed publisher
Lee K, Lin C, Servetto A, Bae J, Kandagatla V, Ye D, et al. Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer. Cancer Immunol Res. 2022;10:829-843 pubmed publisher
Bastard P, Gervais A, Le Voyer T, Rosain J, Philippot Q, Manry J, et al. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths. Sci Immunol. 2021;6: pubmed publisher
Bastard P, Michailidis E, Hoffmann H, Chbihi M, Le Voyer T, Rosain J, et al. Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine. J Exp Med. 2021;218: pubmed publisher
Zheng W, Li L, Zhao D, Wang O, Jiang Y, Xia W, et al. A novel variant in AIRE causing a rare, non‑classical autoimmune polyendocrine syndrome type 1. Mol Med Rep. 2020;22:1285-1294 pubmed publisher
Uebele J, Stein C, Nguyen M, Schneider A, Kleinert F, Ticha O, et al. Antigen delivery to dendritic cells shapes human CD4+ and CD8+ T cell memory responses to Staphylococcus aureus. PLoS Pathog. 2017;13:e1006387 pubmed publisher
Gupta S, Termini J, Issac B, Guirado E, Stone G. Constitutively Active MAVS Inhibits HIV-1 Replication via Type I Interferon Secretion and Induction of HIV-1 Restriction Factors. PLoS ONE. 2016;11:e0148929 pubmed publisher
Borhis G, Burelout C, Chaoul N, Smith N, Goujard C, Meyer L, et al. Plasmacytoid dendritic cells and myeloid cells differently contribute to B-cell-activating factor belonging to the tumor necrosis factor superfamily overexpression during primary HIV infection. AIDS. 2016;30:365-76 pubmed publisher
Zahn S, Rehkämper C, Kummerer B, Ferring Schmidt S, Bieber T, Tüting T, et al. Evidence for a pathophysiological role of keratinocyte-derived type III interferon (IFN?) in cutaneous lupus erythematosus. J Invest Dermatol. 2011;131:133-40 pubmed publisher
Moll H, Freudenthaler H, Zommer A, Buchberger E, Brostjan C. Neutralizing type I IFN antibodies trigger an IFN-like response in endothelial cells. J Immunol. 2008;180:5250-6 pubmed
Megjugorac N, Young H, Amrute S, Olshalsky S, Fitzgerald Bocarsly P. Virally stimulated plasmacytoid dendritic cells produce chemokines and induce migration of T and NK cells. J Leukoc Biol. 2004;75:504-14 pubmed

product information

master code :

21100-1

SKU :

21100-1

product name :

Human IFN-alpha Antibody

unit size :

50 ug

description :

The Human IFN-alpha Antibody from R&D Systems is a mouse monoclonal antibody to IFN-alpha. This antibody reacts with human. The Human IFN-alpha Antibody has been validated for the following applications: Flow Cytometry,Neutralization,Immunohistochemistry-Paraffin,ELISA,Western Blot.

target :

IFN-alpha

category :

Primary Antibodies

buffer :

Phosphate-buffered saline (PBS) containing 0.1% bovine serum albumin (BSA).

clonality :

Monoclonal

clone :

MMHA-2

conjugate :

Unconjugated

host :

Mouse

immunogen :

Human Leukocyte Interferon

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Neutralizes human interferon alpha; binds to human interferon alpha with high affinity (KA ÿ 109 M-1)

gene symbol :

IFNA2

endotoxin note :

<1.0 EU per 1 ╡g of the antibody by the LAL method.

applications :

Flow Cytometry,Neutralization,Immunohistochemistry-Paraffin,ELISA,Western Blot

USD :

449 USD

alt names :

IFNA, IFNA2, IFNA2b, IFNalpha, IFN-alphaA, INFA2, interferon alpha 2, LeIF D

storage :

After receipt, the product may be stored at -20░C for short-term use ( <= 6 months). For long-term storage, we recommend storing the product at -70░C or below for retention of full activity. When thawing, the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. Re-freezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers containing protein such as 0.1% bovine serum albumin (BSA).

more info or order :

R&D Systems product webpage