This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Lymphotoxin-alpha/TNF-beta Protein, CF
catalog :
211-TBB-010/CF
quantity :
10 ug (also 50 ug)
price :
300 USD
citations: 8
Reference
Fellermann M, Huchler C, Fechter L, Kolb T, Wondany F, Mayer D, et al. Clostridial C3 Toxins Enter and Intoxicate Human Dendritic Cells. Toxins (Basel). 2020;12: pubmed publisher
Darling T, Mimche P, Bray C, Umaru B, Brady L, Stone C, et al. EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria. PLoS Pathog. 2020;16:e1008261 pubmed publisher
Chen J, Liu X, Munshi M, Xu L, Tsakmaklis N, Demos M, et al. BTKCys481Ser drives ibrutinib resistance via ERK1/2, and protects BTKWild-Type MYD88 mutated cells by a paracrine mechanism. Blood. 2018;: pubmed publisher
Sarhan D, Palma M, Mao Y, Adamson L, Kiessling R, Mellstedt H, et al. Dendritic cell regulation of NK-cell responses involves lymphotoxin-α, IL-12, and TGF-β. Eur J Immunol. 2015;45:1783-93 pubmed publisher
Steeland S, Puimège L, Vandenbroucke R, Van Hauwermeiren F, Haustraete J, Devoogdt N, et al. Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1. J Biol Chem. 2015;290:4022-37 pubmed publisher
Yaden B, Wang Y, Wilson J, Culver A, Milner A, Datta Mannan A, et al. Inhibition of activin A ameliorates skeletal muscle injury and rescues contractile properties by inducing efficient remodeling in female mice. Am J Pathol. 2014;184:1152-66 pubmed publisher
Vang A, Housley W, Dong H, Basole C, Ben Sasson S, Kream B, et al. Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac. Biochem J. 2013;456:463-73 pubmed publisher
Johnson L, Clasper S, Holt A, Lalor P, Baban D, Jackson D. An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium. J Exp Med. 2006;203:2763-77 pubmed
product information
master code :
211-TBB/CF
SKU :
211-TBB-010/CF
product name :
Recombinant Human Lymphotoxin-alpha/TNF-beta Protein, CF
unit size :
10 ug (also 50 ug)
description :
The Recombinant Human Lymphotoxin-alpha/TNF-beta Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human Lymphotoxin-alpha/TNF-beta Protein, CF has been validated for the following applications: Bioactivity.
target :
Lymphotoxin-alpha/TNF-beta
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
17-19 kDa, reducing conditions
theoretical molecular weight :
19 kDa
gene symbol :
LTA
details of functionality :
Measured in a cytotoxicity assay using L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycináD. Matthews,áN. and M.L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al . (eds): IRL Press. 221. The ED50 for this effect is 4-20 pg/mL.
endotoxin note :
<0.01 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Human Lymphotoxin-alpha/TNF-beta Protein Bioactivity
accessionNumbers :
P01374
applications :
Bioactivity
source long :
E. coli -derived human Lymphotoxin-alpha/TNF-beta protein Leu35-Leu205, with an N-terminal Met
source short :
E. coli
USD :
300 USD
alt names :
LT, LTA, LT-alpha, Lymphotoxin alpha, lymphotoxin alpha (TNF superfamily, member 1), Lymphotoxinalpha, tnfb, TNF-beta, TNFBlymphotoxin-alpha, TNFSF1, TNFSF1B, TNFSF1TNF-beta, tumor necrosis factor beta, Tumor necrosis factor ligand superfamily member 1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.