Recombinant Human Lymphotoxin-alpha/TNF-beta Protein, CF | R&D Systems 211-TBB-010/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Lymphotoxin-alpha/TNF-beta Protein, CF

catalog :

211-TBB-010/CF

quantity :

10 ug (also 50 ug)

price :

274 USD

more info or order :

R&D Systems product webpage

citations: 7

Reference
Fellermann M, Huchler C, Fechter L, Kolb T, Wondany F, Mayer D, et al. Clostridial C3 Toxins Enter and Intoxicate Human Dendritic Cells. Toxins (Basel). 2020;12: pubmed publisher
Darling T, Mimche P, Bray C, Umaru B, Brady L, Stone C, et al. EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria. PLoS Pathog. 2020;16:e1008261 pubmed publisher
Chen J, Liu X, Munshi M, Xu L, Tsakmaklis N, Demos M, et al. BTKCys481Ser drives ibrutinib resistance via ERK1/2, and protects BTKWild-Type MYD88 mutated cells by a paracrine mechanism. Blood. 2018;: pubmed publisher
Sarhan D, Palma M, Mao Y, Adamson L, Kiessling R, Mellstedt H, et al. Dendritic cell regulation of NK-cell responses involves lymphotoxin-Î±, IL-12, and TGF-Î². Eur J Immunol. 2015;45:1783-93 pubmed publisher
Steeland S, PuimÃ¨ge L, Vandenbroucke R, Van Hauwermeiren F, Haustraete J, Devoogdt N, et al. Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1. J Biol Chem. 2015;290:4022-37 pubmed publisher
Yaden B, Wang Y, Wilson J, Culver A, Milner A, Datta Mannan A, et al. Inhibition of activin A ameliorates skeletal muscle injury and rescues contractile properties by inducing efficient remodeling in female mice. Am J Pathol. 2014;184:1152-66 pubmed publisher
Vang A, Housley W, Dong H, Basole C, Ben Sasson S, Kream B, et al. Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac. Biochem J. 2013;456:463-73 pubmed publisher

image

image 1 :

Recombinant Human Lymphotoxin-alpha/TNF-beta Protein Bioactivity

product information

brand :

R&D Systems

master code :

211-TBB/CF

SKU :

211-TBB-010/CF

product name :

Recombinant Human Lymphotoxin-alpha/TNF-beta Protein, CF

description :

The Recombinant Human Lymphotoxin-alpha/TNF-beta Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human Lymphotoxin-alpha/TNF-beta Protein, CF has been validated for the following applications: Bioactivity.

target :

Lymphotoxin-alpha/TNF-beta

category :

Proteins and Enzymes

sizes available :

10 ug (also 50 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

17-19 kDa, reducing conditions

theoretical molecular weight :

19 kDa

gene symbol :

LTA

details of functionality :

Measured in a cytotoxicity assay using L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. Matthews, N. and M.L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al . (eds): IRL Press. 221. The ED50 for this effect is 4-20 pg/mL.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P01374

applications :

Bioactivity

source :

E. coli-derived Recombinant Human Lymphotoxin-alpha/TNF-beta Protein, CF

USD :

269

USD 2023 :

274 USD

alt names :

LT, LTA, LT-alpha, Lymphotoxin alpha, lymphotoxin alpha (TNF superfamily, member 1), Lymphotoxinalpha, tnfb, TNF-beta, TNFBlymphotoxin-alpha, TNFSF1, TNFSF1B, TNFSF1TNF-beta, tumor necrosis factor beta, Tumor necrosis factor ligand superfamily member 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage