Recombinant Human TSG-6 Protein, CF | R&D Systems 2104-TS-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human TSG-6 Protein, CF

catalog :

2104-TS-050

quantity :

50 ug

price :

541 USD

more info or order :

R&D Systems product webpage

citations: 27

Reference
Dodd R, Blundell C, Sattelle B, Enghild J, Milner C, Day A. Chemical modification of hyaluronan oligosaccharides differentially modulates hyaluronan-hyaladherin interactions. J Biol Chem. 2024;300:107668 pubmed publisher
Ding M, Jin L, Wei B, Cheng W, Liu W, Li X, et al. Tumor necrosis factor-stimulated gene-6 ameliorates early brain injury after subarachnoid hemorrhage by suppressing NLRC4 inflammasome-mediated astrocyte pyroptosis. Neural Regen Res. 2024;19:1064-1071 pubmed publisher
Kwon H, Yoon Y, Hong J, Rhee K, Sohn J, Jung P, et al. Role of TGF-β and p38 MAPK in TSG-6 Expression in Adipose Tissue-Derived Stem Cells In Vitro and In Vivo. Int J Mol Sci. 2023;25: pubmed publisher
Jakl V, Popp T, Haupt J, Port M, Roesler R, Wiese S, et al. Effect of Expansion Media on Functional Characteristics of Bone Marrow-Derived Mesenchymal Stromal Cells. Cells. 2023;12: pubmed publisher
Wang A, Ren J, Wang A, Hascall V. Monocyte adhesive hyaluronan matrix induced by hyperglycemia in diabetic lung injuries. J Biol Chem. 2023;299:104995 pubmed publisher
Suzuki K, Kaseyama Takemoto H, Ito S. Highly sensitive quantification of bacterial chondroitin in a culture based on ELISA techniques. J Microbiol Methods. 2022;202:106579 pubmed publisher
Oh J, Ryu J, Kim H, Kouvatsos N, Dodd R, Choi S, et al. The Link module of human TSG-6 (Link_TSG6) promotes wound healing, suppresses inflammation and improves glandular function in mouse models of Dry Eye Disease. Ocul Surf. 2022;24:40-50 pubmed publisher
Evrard C, Faway E, De Vuyst E, Svensek O, De Glas V, Bergerat D, et al. Deletion of TNFAIP6 Gene in Human Keratinocytes Demonstrates a Role for TSG-6 to Retain Hyaluronan Inside Epidermis. JID Innov. 2021;1:100054 pubmed publisher
Nam Y, Yoon D, Hong J, Kim M, Lee T, Kim K, et al. Therapeutic Effects of Human Mesenchymal Stem Cells in a Mouse Model of Cerebellar Ataxia with Neuroinflammation. J Clin Med. 2020;9: pubmed publisher
Yang H, Wu L, Deng H, Chen Y, Zhou H, Liu M, et al. Anti-inflammatory protein TSG-6 secreted by bone marrow mesenchymal stem cells attenuates neuropathic pain by inhibiting the TLR2/MyD88/NF-κB signaling pathway in spinal microglia. J Neuroinflammation. 2020;17:154 pubmed publisher
Bartosh T, Ylostalo J. Efficacy of 3D Culture Priming is Maintained in Human Mesenchymal Stem Cells after Extensive Expansion of the Cells. Cells. 2019;8: pubmed publisher
Muraguchi T, Nanba D, Nishimura E, Tashiro T. IGF-1R deficiency in human keratinocytes disrupts epidermal homeostasis and stem cell maintenance. J Dermatol Sci. 2019;: pubmed publisher
Chen Y, Tang X, Li P, Zhou Y, Xue T, Liu J, et al. Bone Marrow Derived Mesenchymal Stromal Cells Ameliorate Ischemia/Reperfusion Injury-Induced Acute Kidney Injury in Rats via Secreting Tumor Necrosis Factor-Inducible Gene 6 Protein. Biomed Res Int. 2019;2019:9845709 pubmed publisher
Ni K, Gill A, Cao D, Koike K, Schweitzer K, Garantziotis S, et al. Intravascular heavy chain-modification of hyaluronan during endotoxic shock. Biochem Biophys Rep. 2019;17:114-121 pubmed publisher
Lv Y, Gao R, Lin Q, Jiang T, Chen Q, Tang S, et al. The role of TSG-6 and uroplakin III in bladder pain syndrome/ interstitial cystitis in rats and humans. Iran J Basic Med Sci. 2017;20:1242-1249 pubmed publisher
Kui L, Chan G, Lee P. TSG-6 Downregulates IFN-Alpha and TNF-Alpha Expression by Suppressing IRF7 Phosphorylation in Human Plasmacytoid Dendritic Cells. Mediators Inflamm. 2017;2017:7462945 pubmed publisher
He Z, Hua J, Qian D, Gong J, Lin S, Xu C, et al. Intravenous hMSCs Ameliorate Acute Pancreatitis in Mice via Secretion of Tumor Necrosis Factor-α Stimulated Gene/Protein 6. Sci Rep. 2016;6:38438 pubmed publisher
Mittal M, Tiruppathi C, Nepal S, Zhao Y, Grzych D, Soni D, et al. TNFÎ±-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury. Proc Natl Acad Sci U S A. 2016;113:E8151-E8158 pubmed
Watt F, Paterson E, Freidin A, Kenny M, Judge A, Saklatvala J, et al. Acute Molecular Changes in Synovial Fluid Following Human Knee Injury: Association With Early Clinical Outcomes. Arthritis Rheumatol. 2016;68:2129-40 pubmed publisher
Kim D, Choi H, Nishida H, Oh J, Gregory C, Lee R, et al. Scalable Production of a Multifunctional Protein (TSG-6) That Aggregates with Itself and the CHO Cells That Synthesize It. PLoS ONE. 2016;11:e0147553 pubmed publisher
Lauer M, Majors A, COMHAIR S, Ruple L, Matuska B, Subramanian A, et al. Hyaluronan and Its Heavy Chain Modification in Asthma Severity and Experimental Asthma Exacerbation. J Biol Chem. 2015;290:23124-34 pubmed publisher
Hengartner N, Fiedler J, Schrezenmeier H, Huber Lang M, Brenner R. Crucial role of IL1beta and C3a in the in vitro-response of multipotent mesenchymal stromal cells to inflammatory mediators of polytrauma. PLoS ONE. 2015;10:e0116772 pubmed publisher
Lamkin E, Cheng G, Calabro A, Hascall V, Joo E, Li L, et al. Heavy chain transfer by tumor necrosis factor-stimulated gene 6 to the bikunin proteoglycan. J Biol Chem. 2015;290:5156-66 pubmed publisher
Kim H, Darwish I, Monroy M, Prockop D, Liles W, Kain K. Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental staphylococcal toxic shock syndrome. BMC Immunol. 2014;15:1 pubmed publisher
Lauer M, Glant T, Mikecz K, DeAngelis P, Haller F, Husni M, et al. Irreversible heavy chain transfer to hyaluronan oligosaccharides by tumor necrosis factor-stimulated gene-6. J Biol Chem. 2013;288:205-14 pubmed publisher
Roddy G, Oh J, Lee R, Bartosh T, Ylostalo J, Coble K, et al. Action at a distance: systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF-? stimulated gene/protein 6. Stem Cells. 2011;29:1572-9 pubmed publisher
Choi H, Lee R, Bazhanov N, Oh J, Prockop D. Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-?B signaling in resident macrophages. Blood. 2011;118:330-8 pubmed publisher

product information

master code :

2104-TS

SKU :

2104-TS-050

product name :

Recombinant Human TSG-6 Protein, CF

unit size :

50 ug

description :

The Recombinant Human TSG-6 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human TSG-6 Protein, CF has been validated for the following applications: Binding Activity.

target :

TSG-6

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

40 kDa, reducing conditions

theoretical molecular weight :

30.5 kDa

gene symbol :

TNFAIP6

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human TSG-6 is present at 0.5 ╡g/well, the concentration of biotinylated hyaluronan that produces 50% of the optimal binding response is found to be approximately 4-30 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Human TSG-6 Protein Binding Activity

accessionNumbers :

P98066

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived human TSG-6 protein Trp18-Leu277, with a C-terminal 10-His tag

source short :

NS0

USD :

541 USD

alt names :

Hyaluronate-binding protein, TNF alpha-induced protein 6, TNFAIP6, TNF-stimulated gene 6 protein, TSG6, TSG-6tumor necrosis factor alpha-inducible protein 6, TSG6tumor necrosis factor-inducible gene 6 protein, Tumor necrosis factor alpha-induced protein 6, tumor necrosis factor, alpha-induced protein 6, tumor necrosis factor-stimulated gene-6 protein

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage