Recombinant Mouse PRDC/GREM2 Protein, CF | R&D Systems 2069-PR-050/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse PRDC/GREM2 Protein, CF

catalog :

2069-PR-050/CF

quantity :

50 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
He T, Zhang J, Qiao T, Zhang Z, Han H, Yang C, et al. Compensatory roles of Protein Related to DAN and Cerberus (PRDC) decrease in pulmonary arterial hypertension. Int J Biol Sci. 2022;18:2372-2391 pubmed publisher
Gao F, Li C, Danopoulos S, Al Alam D, Peinado N, Webster S, et al. Hedgehog-responsive PDGFRa(+) fibroblasts maintain a unique pool of alveolar epithelial progenitor cells during alveologenesis. Cell Rep. 2022;39:110608 pubmed publisher
Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, et al. Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung. Nat Cell Biol. 2020;22:1295-1306 pubmed publisher
Tanwar V, Bylund J, Hu J, Yan J, Walthall J, Mukherjee A, et al. Gremlin 2 promotes differentiation of embryonic stem cells to atrial fate by activation of the JNK signaling pathway. Stem Cells. 2014;32:1774-88 pubmed publisher

product information

master code :

2069-PR/CF

SKU :

2069-PR-050/CF

product name :

Recombinant Mouse PRDC/GREM2 Protein, CF

unit size :

50 ug

description :

The Recombinant Mouse PRDC/GREM2 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Mouse PRDC/GREM2 Protein, CF has been validated for the following applications: Bioactivity.

target :

PRDC/GREM2

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

theoretical molecular weight :

17.1 kDa (monomer)

gene symbol :

Grem2

details of functionality :

Measured by its ability to inhibit BMP-4-induced activity in MC3T3-E1 mouse preosteoblast cells. The ED50 for this effect is 0.03-0.12 ╡g/mL in the presence of 50 ng/mL of rhBMP-4.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

NP_035955

applications :

Bioactivity

source long :

E. coli -derived mouse PRDC/GREM2 protein Arg22-Gln168, with an N-terminal Met

source short :

E. coli

USD :

432 USD

alt names :

CKTSF1B2, CKTSF1B2FLJ21195, Cysteine knot superfamily 1, BMP antagonist 2, DAN domain family member 3, DAND3, DAND3Prdc, GREM2, gremlin 2, gremlin 2, cysteine knot superfamily, homolog, gremlin-2, PRDCgremlin 2, cysteine knot superfamily, homolog (Xenopus laevis), Protein related to DAN and cerberus

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage