Recombinant Human Galectin-9 Protein, CF | R&D Systems 2045-GA product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Galectin-9 Protein, CF

catalog :

2045-GA

quantity :

1 mg

price :

4378 USD

citations: 4

Reference
Gonçalves Silva I, Ruegg L, Gibbs B, Bardelli M, Fruehwirth A, Varani L, et al. The immune receptor Tim-3 acts as a trafficker in a Tim-3/galectin-9 autocrine loop in human myeloid leukemia cells. Oncoimmunology. 2016;5:e1195535 pubmed publisher
Leskela S, Serrano A, de la Fuente H, RodrÃguez MuÃ±oz A, Ramos Levi A, Sampedro NuÃ±ez M, et al. Graves' disease is associated with a defective expression of the immune regulatory molecule galectin-9 in antigen-presenting dendritic cells. PLoS ONE. 2015;10:e0123938 pubmed publisher
Ungerer C, Quade Lyssy P, Radeke H, Henschler R, Konigs C, Köhl U, et al. Galectin-9 is a suppressor of T and B cells and predicts the immune modulatory potential of mesenchymal stromal cell preparations. Stem Cells Dev. 2014;23:755-66 pubmed publisher
Vaitaitis G, Wagner D. Galectin-9 controls CD40 signaling through a Tim-3 independent mechanism and redirects the cytokine profile of pathogenic T cells in autoimmunity. PLoS ONE. 2012;7:e38708 pubmed publisher

product information

brand :

R&D Systems

master code :

2045-GA

SKU :

2045-GA-01M

product name :

Recombinant Human Galectin-9 Protein, CF

description :

The Recombinant Human Galectin-9 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human Galectin-9 Protein, CF has been validated for the following applications: Bioactivity.

target :

Galectin-9

category :

Proteins and Enzymes

unit size :

1 mg

buffer :

Lyophilized from a 0.2 µm filtered solution in MOPS, NaCl, EDTA, DTT and Trehalose.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

34 kDa, reducing conditions

theoretical molecular weight :

35.8 kDa

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=proteinsandenzymes

details of functionality :

Measured by its ability to induce apoptosis of Jurkat human acute T cell leukemia cells. Lu, L.H. et al . (2007) J. Biochem. 141 :157. The ED50 for this effect is 1-5 µg/mL. Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Galectin-9 at 500 ng/mL can bind Recombinant Human TIM-3 Fc Chimera (Catalog # 2365-TM ) with an apparent Kd 30 nM.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

2045-GA

accessionNumbers :

BAA31542

applications :

Bioactivity

source :

E. coli -derived human Galectin-9 protein Ala2-Thr323

extended description :

HEK293 rh Galectin-9 (Catalog # 9064-GA) is also available. TIM-3 binding is weaker than the E. coli version!

2020 USD :

4378

2021 USD :

4378 USD

product details :

HEK293 rh Galectin-9 (Catalog # 9064-GA) is also available. TIM-3 binding is weaker than the E. coli version!

alt names :

ecalectin, gal-9, GAL9, galectin 9, galectin-9, Galectin9, HUAT, lectin, galactoside-binding, soluble, 9, LGALS9, LGALS9A, MGC117375, MGC125973, MGC125974, Tumor antigen HOM-HD-21, urate transporter/channel protein

storage :

12 months from date of receipt, <= -20 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, <= -20 °C under sterile conditions after reconstitution.