Recombinant Human Galectin-9 Protein, CF | R&D Systems 2045-GA-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Galectin-9 Protein, CF

catalog :

2045-GA-050

quantity :

50 ug (also 1 mg)

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Eriksen L, Nielsen M, Laursen T, Deleuran B, Vilstrup H, St xf8 y S. Early loss of T lymphocyte 4-1BB receptor expression is associated with higher short-term mortality in alcoholic hepatitis. PLoS ONE. 2021;16:e0255574 pubmed publisher
Gonçalves Silva I, Ruegg L, Gibbs B, Bardelli M, Fruehwirth A, Varani L, et al. The immune receptor Tim-3 acts as a trafficker in a Tim-3/galectin-9 autocrine loop in human myeloid leukemia cells. Oncoimmunology. 2016;5:e1195535 pubmed publisher
Leskela S, Serrano A, de la Fuente H, RodrÃguez MuÃ±oz A, Ramos Levi A, Sampedro NuÃ±ez M, et al. Graves' disease is associated with a defective expression of the immune regulatory molecule galectin-9 in antigen-presenting dendritic cells. PLoS ONE. 2015;10:e0123938 pubmed publisher
Ungerer C, Quade Lyssy P, Radeke H, Henschler R, Konigs C, Köhl U, et al. Galectin-9 is a suppressor of T and B cells and predicts the immune modulatory potential of mesenchymal stromal cell preparations. Stem Cells Dev. 2014;23:755-66 pubmed publisher
Gieseke F, Kruchen A, Tzaribachev N, Bentzien F, Dominici M, Müller I. Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation. Eur J Immunol. 2013;43:2741-9 pubmed publisher
Vaitaitis G, Wagner D. Galectin-9 controls CD40 signaling through a Tim-3 independent mechanism and redirects the cytokine profile of pathogenic T cells in autoimmunity. PLoS ONE. 2012;7:e38708 pubmed publisher

image

image 1 :

Recombinant Human Galectin-9 Protein SDS-PAGE

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

2045-GA

SKU :

2045-GA-050

product name :

Recombinant Human Galectin-9 Protein, CF

Description :

The Recombinant Human Galectin-9 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human Galectin-9 Protein, CF has been validated for the following applications: Bioactivity.

target :

Galectin-9

category :

Proteins and Enzymes

unit size :

50 ug (also 1 mg)

buffer :

Lyophilized from a 0.2 µm filtered solution in MOPS, NaCl, EDTA, DTT and Trehalose.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

34 kDa, reducing conditions

theoretical molecular weight :

35.8 kDa

details of functionality :

Measured by its ability to induce apoptosis of Jurkat human acute T cell leukemia cells. Lu, L.H. et al . (2007) J. Biochem. 141 :157. The ED50 for this effect is 1-5 µg/mL. Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Galectin-9 at 500 ng/mL can bind Recombinant Human TIM-3 Fc Chimera (Catalog # 2365-TM ) with an apparent Kd 30 nM.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

BAA31542

applications :

Bioactivity

source :

E. coli-derived Recombinant Human Galectin-9 Protein

USD :

423 USD

alt names :

ecalectin, gal-9, GAL9, galectin 9, galectin-9, Galectin9, HUAT, lectin, galactoside-binding, soluble, 9, LGALS9, LGALS9A, MGC117375, MGC125973, MGC125974, Tumor antigen HOM-HD-21, urate transporter/channel protein

storage :

12 months from date of receipt, <= -20 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, <= -20 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage