product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Kallikrein 8/Neuropsin Protein, CF
catalog :
2025-SE-010
quantity :
10 ug
price :
423 USD
more info or order :
R&D Systems product webpage
citations: 6
Reference
Bosc E, Anastasie J, Soualmia F, Coric P, Kim J, Wang L, et al. Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics. Cell Death Dis. 2022;13:959 pubmed publisher
Attwood B, Bourgognon J, Patel S, Mucha M, Schiavon E, Skrzypiec A, et al. Neuropsin cleaves EphB2 in the amygdala to control anxiety. Nature. 2011;473:372-5 pubmed publisher
Kantyka T, Fischer J, Wu Z, Declercq W, Reiss K, Schroder J, et al. Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6. Peptides. 2011;32:1187-92 pubmed publisher
Meyer Hoffert U, Wu Z, Kantyka T, Fischer J, Latendorf T, Hansmann B, et al. Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases. J Biol Chem. 2010;285:32174-81 pubmed publisher
Sexton D, Chen T, Martik D, Kuzmic P, Kuang G, Chen J, et al. Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases. Biochem J. 2009;422:383-92 pubmed publisher
Yoon H, Laxmikanthan G, Lee J, Blaber S, Rodriguez A, Kogot J, et al. Activation profiles and regulatory cascades of the human kallikrein-related peptidases. J Biol Chem. 2007;282:31852-64 pubmed
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
2025-SE
SKU :
2025-SE-010
product name :
Recombinant Human Kallikrein 8/Neuropsin Protein, CF
Description :
The Recombinant Human Kallikrein 8/Neuropsin Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Kallikrein 8/Neuropsin Protein, CF has been validated for the following applications: Enzyme Activity.
target :
Kallikrein 8/Neuropsin
category :
Proteins and Enzymes
unit size :
10 ug
buffer :
Supplied as a 0.2 µm filtered solution in Tris and NaCl.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
37-39 kDa, reducing conditions
theoretical molecular weight :
26 kDa
gene symbol :
KLK8
details of functionality :
Measured by its ability to cleave the fluorogenic peptide substrate Boc-VPR-AMC (Catalog # ES011 ). The specific activity is 500 pmol/min/µg, as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
O60259
applications :
Enzyme Activity
source :
NS0-derived Recombinant Human Kallikrein 8/Neuropsin Protein
USD :
423 USD
alt names :
EC 3.4.21, EC 3.4.21.118, hK8, HNP, kallikrein 8 (neuropsin/ovasin), kallikrein-related peptidase 8, KLK8, KLK8 protein type 1, KLK8 protein type 2, Neuropsin, neuropsin type 1, neuropsin type 2, NP, NRPN, Ovasin, PRSS19, PRSS19kallikrein-8, Serine protease 19, Serine protease TADG-14, TADG14neuropsin, Tumor-associated differentially expressed gene 14 protein
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.