Recombinant Human KIR2DL3/CD158b2 Fc Chimera Protein, CF | R&D Systems 2014-KR product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human KIR2DL3/CD158b2 Fc Chimera Protein, CF

catalog :

2014-KR

quantity :

50 ug

price :

359 USD

citations: 3

Reference
Thiruchelvam Kyle L, Hoelsbrekken S, Saether P, Bjørnsen E, Pende D, Fossum S, et al. The Activating Human NK Cell Receptor KIR2DS2 Recognizes a ?2-Microglobulin-Independent Ligand on Cancer Cells. J Immunol. 2017;198:2556-2567 pubmed publisher
Cifaldi L, Romania P, Falco M, Lorenzi S, Meazza R, Petrini S, et al. ERAP1 regulates natural killer cell function by controlling the engagement of inhibitory receptors. Cancer Res. 2015;75:824-34 pubmed publisher
Cassidy S, Mukherjee S, Myint T, Mbiribindi B, North H, Traherne J, et al. Peptide selectivity discriminates NK cells from KIR2DL2- and KIR2DL3-positive individuals. Eur J Immunol. 2015;45:492-500 pubmed publisher

product information

brand :

R&D Systems

master code :

2014-KR

SKU :

2014-KR-050

product name :

Recombinant Human KIR2DL3/CD158b2 Fc Chimera Protein, CF

description :

The Recombinant Human KIR2DL3/CD158b2 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human KIR2DL3/CD158b2 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

KIR2DL3/CD158b2

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

66-75 kDa, reducing conditions

theoretical molecular weight :

51.2 kDa (monomer)

gene symbol :

KIR2DL3

details of functionality :

Measured by its ability to bind HEK293T human embryonic kidney cells in a flow cytometry assay. When 10 µg of Recombinant Human KIR2DL3/CD158b2 Fc Chimera is added to 5 x 105 HEK293T cells, 20% of the cells will bind to the protein.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

2014-KR

accessionNumbers :

P43628

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human KIR2DL3/CD158b2 protein Human KIR2DL3 (His22-His245) Accession # P43628 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

2020 USD :

359

2021 USD :

359 USD

alt names :

CD158 antigen-like family member B2, CD158b2, CD158b2 antigen, CD158B2CD158b, cl-6, killer cell immunoglobulin-like receptor 2DL3, killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3, Killer inhibitory receptor cl 2-3, KIR-023GB, KIRCL23, KIR-K7b, KIR-K7c, MGC129943, MHC class I NK cell receptor, natural killer associated transcript 2, natural killer cell inhibitory receptor KIR2DL3, Natural killer-associated transcript 2, NKAT, nkat2, NKAT-2, nkat2a, NKAT2B, NKAT2GL183, NK-receptor, p58, p58 natural killer cell receptor clone CL-6, p58 NK receptor CL-6, p58.2 MHC class-I specific NK receptor, p58.2 MHC class-I-specific NK receptor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.