This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-1 alpha/IL-1F1 Protein, CF
catalog :
200-LA-002/CF
quantity :
2 ug (also 10 ug)
price :
207 USD
citations: 57
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von Stemann J, Rigas A, Thørner L, Rasmussen D, Pedersen O, Rostgaard K, et al. Prevalence and correlation of cytokine-specific autoantibodies with epidemiological factors and C-reactive protein in 8,972 healthy individuals: Results from the Danish Blood Donor Study. PLoS ONE. 2017;12:e0179981 pubmed publisher
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Fernandez Bustamante A, Agazio A, Wilson P, Elkins N, Domaleski L, He Q, et al. Brief Glutamine Pretreatment Increases Alveolar Macrophage CD163/Heme Oxygenase-1/p38-MAPK Dephosphorylation Pathway and Decreases Capillary Damage but Not Neutrophil Recruitment in IL-1/LPS-Insufflated Rats. PLoS ONE. 2015;10:e0130764 pubmed publisher
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Pfleger C, Schloot N, ter Veld F. Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays. J Immunol Methods. 2008;329:214-8 pubmed
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Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, et al. Ultrasensitive flow-based immunoassays using single-molecule counting. Clin Chem. 2007;53:1990-5 pubmed
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Kelley M, Rose A, Song K, Chen Y, Bradley J, Rookhuizen D, et al. Synergism of TNF and IL-1 in the induction of matrix metalloproteinase-3 in trabecular meshwork. Invest Ophthalmol Vis Sci. 2007;48:2634-43 pubmed
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Wilson H, Varcoe R, Stokes L, Holland K, Francis S, Dower S, et al. P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells. Br J Pharmacol. 2007;151:115-27 pubmed
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Brechter A, Lerner U. Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression. Arthritis Rheum. 2007;56:910-23 pubmed
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Biancotto A, Grivel J, Iglehart S, Vanpouille C, Lisco A, Sieg S, et al. Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood. 2007;109:4272-9 pubmed
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Gleissner C, Zastrow A, Klingenberg R, Kluger M, Konstandin M, Celik S, et al. IL-10 inhibits endothelium-dependent T cell costimulation by up-regulation of ILT3/4 in human vascular endothelial cells. Eur J Immunol. 2007;37:177-92 pubmed
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Johnson L, Clasper S, Holt A, Lalor P, Baban D, Jackson D. An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium. J Exp Med. 2006;203:2763-77 pubmed
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Abe Y, Fornage M, Yang C, Bui Thanh N, Wise V, Chen H, et al. L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion. Atherosclerosis. 2007;192:56-66 pubmed
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Li Y, Fan J, Chen M, Li W, Woodley D. Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration. J Invest Dermatol. 2006;126:2096-105 pubmed
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Palmer G, Trolliet S, Talabot Ayer D, Mezin F, Magne D, Gabay C. Pre-interleukin-1alpha expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells: Differential inhibitory effect of interleukin-1 receptor antagonist (icIL-1Ra1). Cytokine. 2005;31:153-60 pubmed
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Dulos J, van der Vleuten M, Kavelaars A, Heijnen C, Boots A. CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines. Arthritis Rheum. 2005;52:770-8 pubmed
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Kao C, Chen Y, Thai P, Wachi S, Huang F, Kim C, et al. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J Immunol. 2004;173:3482-91 pubmed
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Morita K, Miyasako T, Kitayama S, Dohi T. Interleukin-1 inhibits voltage-dependent P/Q-type Ca2+ channel associated with the inhibition of the rise of intracellular free Ca2+ concentration and catecholamine release in adrenal chromaffin cells. Biochim Biophys Acta. 2004;1673:160-9 pubmed
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Smith D, Hanna R, Moore H, Chen H, Farese A, MacVittie T, et al. The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action. Immunity. 2003;18:87-96 pubmed
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product information
master code :
200-LA/CF
SKU :
200-LA-002/CF
product name :
Recombinant Human IL-1 alpha/IL-1F1 Protein, CF
unit size :
2 ug (also 10 ug)
description :
The Recombinant Human IL-1 alpha/IL-1F1 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human IL-1 alpha/IL-1F1 Protein, CF has been validated for the following applications: Bioactivity.
target :
IL-1 alpha/IL-1F1
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
theoretical molecular weight :
18 kDa
gene symbol :
IL1A
details of functionality :
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. Symons, J.A. etáal . (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. etáal . (eds): IRL Press. 272. The ED50 for this effect is 1-6 pg/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Human IL-1 alpha/IL-1F1 Protein Bioactivity
accessionNumbers :
Q53QF9
applications :
Bioactivity
source long :
E. coli -derived human IL-1 alpha/IL-1F1 protein Ser113-Ala271
source short :
E. coli
USD :
207 USD
alt names :
BAF, Hematopoietin-1, IL1, IL1 alpha, IL-1 alpha, IL1A, IL-1A, IL1-ALPHA, IL1F1, IL-1F1, IL1F1hematopoietin-1, interleukin 1, alpha, interleukin-1 alpha, LAF, LEM, preinterleukin 1 alpha, pro-interleukin-1-alpha
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after opening.
company information

R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.
questions and comments
