This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-37/IL-1F7 Protein, CF
catalog :
1975-IL
quantity :
25 ug
price :
329 USD
citations: 7
Reference
Zhao Y, Ni X, Xu P, Liu Q, Sun T, Liu X, et al. Interleukin-37 reduces inflammation and impairs phagocytosis of platelets in immune thrombocytopenia (ITP). Cytokine. 2020;125:154853 pubmed publisher
Ye C, Zhang W, Hang K, Chen M, Hou W, Chen J, et al. Extracellular IL-37 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the PI3K/AKT signaling pathway. Cell Death Dis. 2019;10:753 pubmed publisher
Zhao M, Li Y, Guo C, Wang L, Chu H, Zhu F, et al. IL-37 isoform D downregulates pro-inflammatory cytokines expression in a Smad3-dependent manner. Cell Death Dis. 2018;9:582 pubmed publisher
Jiang M, Wang Y, Zhang H, Ji Y, Zhao P, Sun R, et al. IL-37 inhibits invasion and metastasis in non-small cell lung cancer by suppressing the IL-6/STAT3 signaling pathway. Thorac Cancer. 2018;9:621-629 pubmed publisher
Chi H, Liu D, Sun Y, Hu Q, Liu H, Cheng X, et al. Interleukin-37 is increased in adult-onset Still's disease and associated with disease activity. Arthritis Res Ther. 2018;20:54 pubmed publisher
Lacy S, Wu C, Ambrosi D, Hsieh C, Bose S, Miller R, et al. Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β. MAbs. 2015;7:605-19 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
product information
brand :
R&D Systems
master code :
1975-IL
SKU :
1975-IL-025
product name :
Recombinant Human IL-37/IL-1F7 Protein, CF
description :
The Recombinant Human IL-37/IL-1F7 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human IL-37/IL-1F7 Protein, CF has been validated for the following applications: Binding Activity.
target :
IL-37/IL-1F7
category :
Proteins and Enzymes
unit size :
25 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS and DTT.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
theoretical molecular weight :
18.6 kDa
gene symbol :
IL37
details of functionality :
Measured by its binding ability in a functional ELISA. When Recombinant Human (rh) IL-18 R alpha/IL-1 R5 Fc Chimera (Catalog # 816-LR ) is immobilized at 2 µg/mL (100 µL/well), the concentration of rhIL-37/IL-1F7 Chimera that produces 50% optimal binding response is 20-120 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
catalog number base :
1975-IL
accessionNumbers :
NP_775297
applications :
Binding Activity
source :
E. coli -derived human IL-37/IL-1F7 protein Lys27-Asp192, with an N-terminal Met
extended description :
rh IL-37 Isoform b (7585-IL) is also available!
2020 USD :
329
2021 USD :
329 USD
product details :
rh IL-37 Isoform b (7585-IL) is also available!
alt names :
FIL1, FIL1 zeta, FIL1(ZETA), FIL1ZFIL1 zeta, IL-1F7, IL-1F7IL-1 zeta, IL1H4IL1F7 (canonical product IL-1F7b), IL-1H4IL-1F7b (IL-1H4, IL-1H, IL-1RP1), IL-1RP1IL-1X protein, IL1RP1interleukin 1 family member 7, IL-1X, IL37, interleukin 1 family, member 7 (zeta), interleukin 1, zeta, interleukin-1 family member 7, Interleukin-1 homolog 4, interleukin-1 superfamily z, Interleukin-1 zeta, Interleukin-1-related protein
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.