Recombinant Human IL-37/IL-1F7 Protein, CF | R&D Systems 1975-IL-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-37/IL-1F7 Protein, CF

catalog :

1975-IL-025

quantity :

25 ug

price :

400 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Ma N, Yuan C, Shi J, Zhu Q, Liu Y, Ma X, et al. Interleukin-37 protects against acinar cell pyroptosis in acute pancreatitis. JCI Insight. 2022;7: pubmed publisher
Ye C, Zhang W, Hang K, Chen M, Hou W, Chen J, et al. Extracellular IL-37 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the PI3K/AKT signaling pathway. Cell Death Dis. 2019;10:753 pubmed publisher
Zhao Y, Ni X, Xu P, Liu Q, Sun T, Liu X, et al. Interleukin-37 reduces inflammation and impairs phagocytosis of platelets in immune thrombocytopenia (ITP). Cytokine. 2020;125:154853 pubmed publisher
Li L, Wei J, Li S, Jacko A, Weathington N, Mallampalli R, et al. The deubiquitinase USP13 stabilizes the anti-inflammatory receptor IL-1R8/Sigirr to suppress lung inflammation. EBioMedicine. 2019;: pubmed publisher
Zhao M, Li Y, Guo C, Wang L, Chu H, Zhu F, et al. IL-37 isoform D downregulates pro-inflammatory cytokines expression in a Smad3-dependent manner. Cell Death Dis. 2018;9:582 pubmed publisher
Jiang M, Wang Y, Zhang H, Ji Y, Zhao P, Sun R, et al. IL-37 inhibits invasion and metastasis in non-small cell lung cancer by suppressing the IL-6/STAT3 signaling pathway. Thorac Cancer. 2018;9:621-629 pubmed publisher
Chi H, Liu D, Sun Y, Hu Q, Liu H, Cheng X, et al. Interleukin-37 is increased in adult-onset Still's disease and associated with disease activity. Arthritis Res Ther. 2018;20:54 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher

product information

brand :

R&D Systems

master code :

1975-IL

SKU :

1975-IL-025

product name :

Recombinant Human IL-37/IL-1F7 Protein, CF

unit size :

25 ug

seo description :

The Recombinant Human IL-37/IL-1F7 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human IL-37/IL-1F7 Protein, CF has been validated for the following applications: Binding Activity.

target :

IL-37/IL-1F7

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS and DTT.

conjugate :

Unconjugated

dilution :

Binding Activity

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

theoretical molecular weight :

18.6 kDa

gene symbol :

IL37

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human (rh) IL-18 R alpha /IL-1 R5 Fc Chimera (Catalog # 816-LR ) is immobilized at 2 ╡g/mL (100 ╡L/well), the concentration of rhIL-37/IL-1F7 Chimera that produces 50% optimal binding response is 20-120 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

NP_775297

applications :

Binding Activity

source :

E. coli-derived Recombinant Human IL-37/IL-1F7 Protein, CF

USD :

400 USD

alt names :

FIL1, FIL1 zeta, FIL1(ZETA), FIL1ZFIL1 zeta, IL-1F7, IL-1F7IL-1 zeta, IL1H4IL1F7 (canonical product IL-1F7b), IL-1H4IL-1F7b (IL-1H4, IL-1H, IL-1RP1), IL-1RP1IL-1X protein, IL1RP1interleukin 1 family member 7, IL-1X, IL37, interleukin 1 family, member 7 (zeta), interleukin 1, zeta, interleukin-1 family member 7, Interleukin-1 homolog 4, interleukin-1 superfamily z, Interleukin-1 zeta, Interleukin-1-related protein

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage