product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse Noggin Protein, CF
catalog :
1967-NG-025/CF
quantity :
25 ug (also 100 ug)
price :
425 USD
more info or order :
citations: 84
Reference
Yamada A, Yoshizaki K, Saito K, Ishikawa M, Chiba Y, Hoshikawa S, et al. GSK3beta inhibitor-induced dental mesenchymal stem cells regulate ameloblast differentiation. J Oral Biosci. 2022;64:400-409 pubmed publisher
Caldwell A, Sancho L, Deng J, Bosworth A, Miglietta A, Diedrich J, et al. Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders. Nat Neurosci. 2022;25:1163-1178 pubmed publisher
Watanabe S, Kobayashi S, Ogasawara N, Okamoto R, Nakamura T, Watanabe M, et al. Transplantation of intestinal organoids into a mouse model of colitis. Nat Protoc. 2022;17:649-671 pubmed publisher
Kim T, Kim S, Kim Y, Lee Y, Lee S, Lee S, et al. A High-Fat Diet Activates the BAs-FXR Axis and Triggers Cancer-Associated Fibroblast Properties in the Colon. Cell Mol Gastroenterol Hepatol. 2022;13:1141-1159 pubmed publisher
Mackinlay K, Weatherbee B, Souza Rosa V, Handford C, Hudson G, Coorens T, et al. An in vitro stem cell model of human epiblast and yolk sac interaction. elife. 2021;10: pubmed publisher
Correia A, Straub D, Calpe S, Krishnadath K. Novel In Vivo Mouse Cryoablation Model to Explore Unique Therapeutic Approaches for Premalignant Columnar Lesions. Methods Protoc. 2021;4: pubmed publisher
Morikawa R, Nemoto Y, Yonemoto Y, Tanaka S, Takei Y, Oshima S, et al. Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal. Cell Mol Gastroenterol Hepatol. 2021;11:1483-1503 pubmed publisher
Bilotta A, Ma C, Yang W, Yu Y, Yu Y, Zhao X, et al. Propionate Enhances Cell Speed and Persistence to Promote Intestinal Epithelial Turnover and Repair. Cell Mol Gastroenterol Hepatol. 2021;11:1023-1044 pubmed publisher
Chien S, Tsai C, Liu S, Huang C, Lin T, Yang Y, et al. Noggin Inhibits IL-1β and BMP-2 Expression, and Attenuates Cartilage Degeneration and Subchondral Bone Destruction in Experimental Osteoarthritis. Cells. 2020;9: pubmed publisher
Binder M, Biggs L, Kronenberg M, Schneider P, Thesleff I, Balic A. Novel strategies for expansion of tooth epithelial stem cells and ameloblast generation. Sci Rep. 2020;10:4963 pubmed publisher
Kang S, Long K, Wang S, Sada A, Tumbar T. Histone H3 K4/9/27 Trimethylation Levels Affect Wound Healing and Stem Cell Dynamics in Adult Skin. Stem Cell Reports. 2020;14:34-48 pubmed publisher
Ali M, Kabir F, Thomson J, Ma Y, Qiu C, Delannoy M, et al. Comparative transcriptome analysis of hESC- and iPSC-derived lentoid bodies. Sci Rep. 2019;9:18552 pubmed publisher
Boone P, Rochelle L, Ginzel J, Lubkov V, Roberts W, Nicholls P, et al. A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion. Nat Commun. 2019;10:5490 pubmed publisher
Jones L, Vaida A, Thompson L, Ikuomola F, Caamano J, Burkitt M, et al. NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells. Cell Death Dis. 2019;10:896 pubmed publisher
Bakhti M, Scheibner K, Tritschler S, Bastidas Ponce A, Tarquis Medina M, Theis F, et al. Establishment of a high-resolution 3D modeling system for studying pancreatic epithelial cell biology in vitro. Mol Metab. 2019;30:16-29 pubmed publisher
Chen C, Yang Y, Yao Y. HBO Promotes the Differentiation of Neural Stem Cells via Interactions Between the Wnt3/β-Catenin and BMP2 Signaling Pathways. Cell Transplant. 2019;28:1686-1699 pubmed publisher
Inoue F, Kreimer A, Ashuach T, Ahituv N, Yosef N. Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction. Cell Stem Cell. 2019;25:713-727.e10 pubmed publisher
Kim Y, Lee Y, Kang S, Kim S, Kim T, Lee S, et al. Loss of PKM2 in Lgr5+ intestinal stem cells promotes colitis-associated colorectal cancer. Sci Rep. 2019;9:6212 pubmed publisher
Meng Z, Gwag T, Sui Y, Park S, Zhou X, Zhou C. The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling. JCI Insight. 2019;4: pubmed publisher
Yu L, Dawson L, Yan M, Zimmel K, Lin Y, Dolan C, et al. BMP9 stimulates joint regeneration at digit amputation wounds in mice. Nat Commun. 2019;10:424 pubmed publisher
Lager A, Corradin O, Cregg J, Elitt M, Shick H, Clayton B, et al. Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells. Nat Commun. 2018;9:3708 pubmed publisher
Chen F, Yang W, Huang X, Cao A, Bilotta A, Xiao Y, et al. Neutrophils Promote Amphiregulin Production in Intestinal Epithelial Cells through TGF-? and Contribute to Intestinal Homeostasis. J Immunol. 2018;: pubmed publisher
Spangler A, Su E, Craft A, Cahan P. A single cell transcriptional portrait of embryoid body differentiation and comparison to progenitors of the developing embryo. Stem Cell Res. 2018;31:201-215 pubmed publisher
Choksi Y, Reddy V, Singh K, Barrett C, Short S, Parang B, et al. BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability. Mucosal Immunol. 2018;11:1363-1374 pubmed publisher
Boyd M, Thodberg M, Vitezic M, Bornholdt J, Vitting Seerup K, Chen Y, et al. Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies. Nat Commun. 2018;9:1661 pubmed publisher
Willems B, Furmanik M, Caron M, Chatrou M, Kusters D, Welting T, et al. Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling. Sci Rep. 2018;8:4961 pubmed publisher
Brown J, Short S, Stencel Baerenwald J, Urbanek K, Pruijssers A, McAllister N, et al. Reovirus-Induced Apoptosis in the Intestine Limits Establishment of Enteric Infection. J Virol. 2018;92: pubmed publisher
Takahashi T, Shiraishi A, Murata J. The Coordinated Activities of nAChR and Wnt Signaling Regulate Intestinal Stem Cell Function in Mice. Int J Mol Sci. 2018;19: pubmed publisher
Järvinen E, Shimomura Kuroki J, Balic A, Jussila M, Thesleff I. Mesenchymal Wnt/β-catenin signaling limits tooth number. Development. 2018;145: pubmed publisher
Li B, Dorrell C, Canaday P, Pelz C, Haft A, Finegold M, et al. Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes. Stem Cell Reports. 2017;9:478-489 pubmed publisher
Bernatik O, Radaszkiewicz T, Behal M, Dave Z, Witte F, Mahl A, et al. A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation. Front Cell Dev Biol. 2017;5:47 pubmed publisher
Chao J, Lamba D, Klesert T, Torre A, Hoshino A, Taylor R, et al. Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate. Transl Vis Sci Technol. 2017;6:4 pubmed publisher
McCauley K, Hawkins F, Serra M, Thomas D, JACOB A, Kotton D. Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling. Cell Stem Cell. 2017;20:844-857.e6 pubmed publisher
Lee J, Snyder E, Liu Y, Gu X, Wang J, Flowers B, et al. Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells. Nat Commun. 2017;8:14686 pubmed publisher
Espuny Camacho I, Arranz A, Fiers M, Snellinx A, Ando K, Munck S, et al. Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain. Neuron. 2017;93:1066-1081.e8 pubmed publisher
Barry C, Schmitz M, Jiang P, Schwartz M, Duffin B, Swanson S, et al. Species-specific developmental timing is maintained by pluripotent stem cells ex utero. Dev Biol. 2017;423:101-110 pubmed publisher
Nigmatullina L, Norkin M, Dzama M, Messner B, Sayols S, Soshnikova N. Id2 controls specification of Lgr5+ intestinal stem cell progenitors during gut development. EMBO J. 2017;36:869-885 pubmed publisher
Kwon H, Lee G, Chun H. Electrical stimulation drives chondrogenesis of mesenchymal stem cells in the absence of exogenous growth factors. Sci Rep. 2016;6:39302 pubmed publisher
Varun D, Srinivasan G, Tsai Y, Kim H, Cutts J, Petty F, et al. A robust vitronectin-derived peptide for the scalable long-term expansion and neuronal differentiation of human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs). Acta Biomater. 2017;48:120-130 pubmed publisher
Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, et al. Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors. Biochem Biophys Res Commun. 2017;482:1296-1303 pubmed publisher
Lee J, Kang S, Lilja K, Colletier K, Scheitz C, Zhang Y, et al. Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis. Nat Commun. 2016;7:11278 pubmed publisher
Carthy J, Engström U, Heldin C, Moustakas A. Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF-β Signaling. J Cell Biochem. 2016;117:938-45 pubmed publisher
Barrett C, Reddy V, Short S, Motley A, Lintel M, Bradley A, et al. Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage. J Clin Invest. 2015;125:2646-60 pubmed publisher
Shojaie S, Ermini L, Ackerley C, Wang J, Chin S, Yeganeh B, et al. Acellular lung scaffolds direct differentiation of endoderm to functional airway epithelial cells: requirement of matrix-bound HS proteoglycans. Stem Cell Reports. 2015;4:419-30 pubmed publisher
Göttle P, Sabo J, Heinen A, Venables G, Torres K, Tzekova N, et al. Oligodendroglial maturation is dependent on intracellular protein shuttling. J Neurosci. 2015;35:906-19 pubmed publisher
McElroy S, Castle S, Bernard J, Almohazey D, Hunter C, Bell B, et al. The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis. Am J Pathol. 2014;184:2768-78 pubmed publisher
Fukuda M, Mizutani T, Mochizuki W, Matsumoto T, Nozaki K, Sakamaki Y, et al. Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon. Genes Dev. 2014;28:1752-7 pubmed publisher
Capaldo C, Farkas A, Hilgarth R, Krug S, Wolf M, Benedik J, et al. Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins. Mol Biol Cell. 2014;25:2710-9 pubmed publisher
Poh Y, Chen J, Hong Y, Yi H, Zhang S, Chen J, et al. Generation of organized germ layers from a single mouse embryonic stem cell. Nat Commun. 2014;5:4000 pubmed publisher
Park J, Jang S, Park D, Lim N, Deng C, Kim D, et al. Cooperativity of E-cadherin and Smad4 loss to promote diffuse-type gastric adenocarcinoma and metastasis. Mol Cancer Res. 2014;12:1088-99 pubmed publisher
Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, et al. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat Commun. 2014;5:3492 pubmed publisher
Yap C, Goh H, Familari M, Rathjen P, Rathjen J. The formation of proximal and distal definitive endoderm populations in culture requires p38 MAPK activity. J Cell Sci. 2014;127:2204-16 pubmed publisher
Singh A, Chappell J, Trost R, Lin L, Wang T, Tang J, et al. Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells. Stem Cell Reports. 2013;1:532-44 pubmed publisher
Brafman D, Moya N, Allen Soltero S, Fellner T, Robinson M, McMillen Z, et al. Analysis of SOX2-expressing cell populations derived from human pluripotent stem cells. Stem Cell Reports. 2013;1:464-78 pubmed publisher
Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, et al. Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. elife. 2013;2:e00940 pubmed publisher
Guan J, Li H, Lv T, Chen D, Yuan Y, Qu S. Bone morphogenetic protein-7 (BMP-7) mediates ischemic preconditioning-induced ischemic tolerance via attenuating apoptosis in rat brain. Biochem Biophys Res Commun. 2013;441:560-6 pubmed publisher
Lewis C, Mardaryev A, Poterlowicz K, Sharova T, Aziz A, Sharpe D, et al. Bone morphogenetic protein signaling suppresses wound-induced skin repair by inhibiting keratinocyte proliferation and migration. J Invest Dermatol. 2014;134:827-837 pubmed publisher
Wang Y, Wu B, Chamberlain A, Lui W, Koirala P, Susztak K, et al. Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development. PLoS ONE. 2013;8:e60244 pubmed publisher
Li S, Meyer N, Quarto N, Longaker M. Integration of multiple signaling regulates through apoptosis the differential osteogenic potential of neural crest-derived and mesoderm-derived Osteoblasts. PLoS ONE. 2013;8:e58610 pubmed publisher
Huegel J, Mundy C, Sgariglia F, Nygren P, Billings P, Yamaguchi Y, et al. Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses. Dev Biol. 2013;377:100-12 pubmed publisher
Mehta V, Schmitz C, Keil K, Joshi P, Abler L, Lin T, et al. Beta-catenin (CTNNB1) induces Bmp expression in urogenital sinus epithelium and participates in prostatic bud initiation and patterning. Dev Biol. 2013;376:125-35 pubmed publisher
Tucker B, Anfinson K, Mullins R, Stone E, Young M. Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and retinal differentiation. Stem Cells Transl Med. 2013;2:16-24 pubmed publisher
Chen J, Liu H, Liu J, Qi J, Wei B, Yang J, et al. H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet. 2013;45:34-42 pubmed publisher
Brafman D, Phung C, Kumar N, Willert K. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. Cell Death Differ. 2013;20:369-81 pubmed publisher
Sneddon J, Borowiak M, Melton D. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature. 2012;491:765-8 pubmed publisher
Ueki Y, Reh T. Activation of BMP-Smad1/5/8 signaling promotes survival of retinal ganglion cells after damage in vivo. PLoS ONE. 2012;7:e38690 pubmed publisher
Chen T, Heller E, Beronja S, Oshimori N, Stokes N, Fuchs E. An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration. Nature. 2012;485:104-8 pubmed publisher
Wang P, McKnight K, Wong D, Rodriguez R, Sugiyama T, Gu X, et al. A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells. Stem Cells Dev. 2012;21:2273-87 pubmed publisher
Kawaguchi J, Nichols J, Gierl M, Faial T, Smith A. Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos. Development. 2010;137:693-704 pubmed publisher
Du Y, Xiao Q, Yip H. Regulation of retinal progenitor cell differentiation by bone morphogenetic protein 4 is mediated by the smad/id cascade. Invest Ophthalmol Vis Sci. 2010;51:3764-73 pubmed publisher
Hayashi K, Surani M. Self-renewing epiblast stem cells exhibit continual delineation of germ cells with epigenetic reprogramming in vitro. Development. 2009;136:3549-56 pubmed publisher
Sellers D, Maris D, Horner P. Postinjury niches induce temporal shifts in progenitor fates to direct lesion repair after spinal cord injury. J Neurosci. 2009;29:6722-33 pubmed publisher
Kelley R, Ren R, Pi X, Wu Y, Moreno I, Willis M, et al. A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling. J Cell Biol. 2009;184:597-609 pubmed publisher
Kobune M, Kawano Y, Takahashi S, Takada K, Murase K, Iyama S, et al. Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-) cells. Exp Hematol. 2008;36:1121-31 pubmed publisher
Matsuura I, Taniguchi J, Hata K, Saeki N, Yamashita T. BMP inhibition enhances axonal growth and functional recovery after spinal cord injury. J Neurochem. 2008;105:1471-9 pubmed publisher
Zhang P, Li J, Tan Z, Wang C, Liu T, Chen L, et al. Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood. 2008;111:1933-41 pubmed
Fuller M, DeChant A, Rothstein B, Caprariello A, Wang R, Hall A, et al. Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions. Ann Neurol. 2007;62:288-300 pubmed
Stavridis M, Lunn J, Collins B, Storey K. A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification. Development. 2007;134:2889-94 pubmed
Lin L, Valore E, Nemeth E, Goodnough J, Gabayan V, Ganz T. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood. 2007;110:2182-9 pubmed
Tiecke E, Bangs F, Blaschke R, Farrell E, Rappold G, Tickle C. Expression of the short stature homeobox gene Shox is restricted by proximal and distal signals in chick limb buds and affects the length of skeletal elements. Dev Biol. 2006;298:585-96 pubmed
Schlueter J, Männer J, Brand T. BMP is an important regulator of proepicardial identity in the chick embryo. Dev Biol. 2006;295:546-58 pubmed
Maeshima A, Vaughn D, Choi Y, Nigam S. Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev Biol. 2006;295:473-85 pubmed
Yao S, Chen S, Clark J, Hao E, Beattie G, Hayek A, et al. Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions. Proc Natl Acad Sci U S A. 2006;103:6907-12 pubmed
Brugmann S, Pandur P, Kenyon K, Pignoni F, Moody S. Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor. Development. 2004;131:5871-81 pubmed
product information
brand :
R&D Systems
master code :
1967-NG/CF
SKU :
1967-NG-025/CF
product name :
Recombinant Mouse Noggin Protein, CF
unit size :
25 ug (also 100 ug)
seo description :
The Recombinant Mouse Noggin Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse Noggin Protein, CF has been validated for the following applications: Bioactivity.
target :
Noggin
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Mouse
observed molecular weight :
30-35 kDa, reducing conditions
theoretical molecular weight :
26 kDa (monomer)
gene symbol :
Nog
details of functionality :
Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 0.06-0.3 ╡g/mL in the presence of 50 ng/mL of Recombinant Human BMP-4 (Catalog # 314-BP ).
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Graph showing dose-dependent bioactivity of mouse Noggin protein
accessionNumbers :
P97466
applications :
Bioactivity
source :
NS0-derived Recombinant Mouse Noggin Protein, CF
extended description :
A New rm Noggin is Now Available! ~2 fold better activity; Lower endotoxin specification; Enhanced purity; No tag!
USD :
425 USD
product details :
A New rm Noggin is Now Available! ~2 fold better activity; Lower endotoxin specification; Enhanced purity; No tag!
alt names :
NOG, noggin, SYM1, symphalangism 1 (proximal), synostoses (multiple) syndrome 1, SYNS1, SYNS1A
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.