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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-24 Protein, CF
catalog :
1965-IL-025/CF
quantity :
25 ug
price :
432 USD
more info or order :
citations: 17
Reference
Liu Y, Chen Y, Sha R, Li Y, Xu T, Hu X, et al. A new insight into the role of aryl hydrocarbon receptor (AhR) in the migration of glioblastoma by AhR-IL24 axis regulation. Environ Int. 2021;154:106658 pubmed publisher
Pap D, Veres Székely A, Szebeni B, Rokonay R, Onody A, Lippai R, et al. Characterization of IL-19, -20, and -24 in acute and chronic kidney diseases reveals a pro-fibrotic role of IL-24. J Transl Med. 2020;18:172 pubmed publisher
Delic D, Wolk K, Schmid R, Gabrielyan O, Christou D, Rieber K, et al. Integrated microRNA/mRNA expression profiling of the skin of psoriasis patients. J Dermatol Sci. 2020;97:9-20 pubmed publisher
Kumar N, Moideen K, Banurekha V, Nair D, Babu S. Modulation of Th1/Tc1 and Th17/Tc17 responses in pulmonary tuberculosis by IL-20 subfamily of cytokines. Cytokine. 2018;108:190-196 pubmed publisher
Kawada S, Nagasawa Y, Kawabe M, Ohyama H, Kida A, Kato Kogoe N, et al. Iron-induced calcification in human aortic vascular smooth muscle cells through interleukin-24 (IL-24), with/without TNF-alpha. Sci Rep. 2018;8:658 pubmed publisher
Ross B, Gao N, Cui X, Standiford T, Xu J, Yu F. IL-24 Promotes Pseudomonas aeruginosa Keratitis in C57BL/6 Mouse Corneas. J Immunol. 2017;198:3536-3547 pubmed publisher
Pap D, Sziksz E, Kiss Z, Rokonay R, Veres Székely A, Lippai R, et al. Microarray Analysis Reveals Increased Expression of Matrix Metalloproteases and Cytokines of Interleukin-20 Subfamily in the Kidneys of Neonate Rats Underwent Unilateral Ureteral Obstruction: A Potential Role of IL-24 in the Regulation of Inflammatio. Kidney Blood Press Res. 2017;42:16-32 pubmed publisher
Tsaousi A, Witte E, Witte K, Röwert Huber H, Volk H, Sterry W, et al. MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations. Mediators Inflamm. 2016;2016:4097574 pubmed
Kumari S, Bonnet M, Ulvmar M, Wolk K, Karagianni N, Witte E, et al. Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. Immunity. 2013;39:899-911 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Heinemann A, He Y, Zimina E, Boerries M, Busch H, Chmel N, et al. Induction of phenotype modifying cytokines by FERMT1 mutations. Hum Mutat. 2011;32:397-406 pubmed publisher
Maarof G, Bouchet Delbos L, Gary Gouy H, Durand Gasselin I, Krzysiek R, Dalloul A. Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells. Blood. 2010;115:1718-26 pubmed publisher
Tohyama M, Hanakawa Y, Shirakata Y, Dai X, Yang L, Hirakawa S, et al. IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression. Eur J Immunol. 2009;39:2779-88 pubmed publisher
Duluc D, Corvaisier M, Blanchard S, Catala L, Descamps P, Gamelin E, et al. Interferon-gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages. Int J Cancer. 2009;125:367-73 pubmed publisher
Wu B, Huang C, Kato Maeda M, Hopewell P, Daley C, Krensky A, et al. IL-24 modulates IFN-gamma expression in patients with tuberculosis. Immunol Lett. 2008;117:57-62 pubmed publisher
Tahara I, Miyake K, Hanawa H, Kurai T, Hirai Y, Ishizaki M, et al. Systemic cancer gene therapy using adeno-associated virus type 1 vector expressing MDA-7/IL24. Mol Ther. 2007;15:1805-11 pubmed
Sa S, Valdez P, Wu J, Jung K, Zhong F, Hall L, et al. The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J Immunol. 2007;178:2229-40 pubmed
product information
master code :
1965-IL/CF
SKU :
1965-IL-025/CF
product name :
Recombinant Human IL-24 Protein, CF
unit size :
25 ug
description :
The Recombinant Human IL-24 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IL-24 Protein, CF has been validated for the following applications: Bioactivity.
target :
IL-24
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
26-35 kDa, reducing conditions
theoretical molecular weight :
19.5 kDa
gene symbol :
IL24
details of functionality :
Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with human IL-20 R alpha and human IL-20 R▀. The ED50 for this effect is 15-150 pg/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q13007
applications :
Bioactivity
source long :
Mouse myeloma cell line, NS0-derived human IL-24 protein Met28-Leu206, with a C-terminal 10-His tag
source short :
NS0
USD :
432 USD
alt names :
C49A, FISP, IL10B, IL24, IL-24, interleukin 24, mda-7, MDA7MOB5, melanocyte-associated Mda-7, melanoma differentiation association protein 7, Melanoma differentiation-associated gene 7 protein, MOB-5, ST16, ST16interleukin-24, suppression of tumorigenicity 16 (melanoma differentiation), Suppression of tumorigenicity 16 protein
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.