product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human/Mouse/Rat GDF-11/BMP-11 Protein
catalog :
1958-GD-010
quantity :
10 ug
price :
400 USD
more info or order :
R&D Systems product webpage
citations: 27
Reference
Wang Z, Jiang P, Liu F, Du X, Ma L, Ye S, et al. GDF11 Regulates PC12 Neural Stem Cells via ALK5-Dependent PI3K-Akt Signaling Pathway. Int J Mol Sci. 2022;23: pubmed publisher
Xiang G, Ying K, Jiang P, Jia M, Sun Y, Li S, et al. Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension. Skelet Muscle. 2022;12:10 pubmed publisher
Sun J, Li Y, Yang X, Dong W, Yang J, Hu Q, et al. Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy. Aging Cell. 2022;21:e13532 pubmed publisher
Xiao A, Zhang Y, Ren Y, Chen R, Li T, You C, et al. GDF11 alleviates secondary brain injury after intracerebral hemorrhage via attenuating mitochondrial dynamic abnormality and dysfunction. Sci Rep. 2021;11:3974 pubmed publisher
Hagg A, Kharoud S, Goodchild G, Goodman C, Chen J, Thomson R, et al. TMEPAI/PMEPA1 Is a Positive Regulator of Skeletal Muscle Mass. Front Physiol. 2020;11:560225 pubmed publisher
De Rosa G, Andolfo I, Marra R, Manna F, Rosato B, Iolascon A, et al. RAP-011 Rescues the Disease Phenotype in a Cellular Model of Congenital Dyserythropoietic Anemia Type II by Inhibiting the SMAD2-3 Pathway. Int J Mol Sci. 2020;21: pubmed publisher
Idkowiak Baldys J, Santhanam U, Buchanan S, PFAFF K, Rubin L, Lyga J. Growth differentiation factor 11 (GDF11) has pronounced effects on skin biology. PLoS ONE. 2019;14:e0218035 pubmed publisher
Jin Q, Qiao C, Li J, Xiao B, Li J, Xiao X. A GDF11/myostatin inhibitor, GDF11 propeptide-Fc, increases skeletal muscle mass and improves muscle strength in dystrophic mdx mice. Skelet Muscle. 2019;9:16 pubmed publisher
Kim J, Kim J, Sutikno L, Lee S, Jin D, Hong Y, et al. Identification of the minimum region of flatfish myostatin propeptide (Pep45-65) for myostatin inhibition and its potential to enhance muscle growth and performance in animals. PLoS ONE. 2019;14:e0215298 pubmed publisher
Zhang X, Tan H, Shi Z, Li N, Jia Y, Hao Z. Growth differentiation factor 11 is involved in isoproterenol‑induced heart failure. Mol Med Rep. 2019;19:4109-4118 pubmed publisher
Qian L, Zhang H, Gu Y, Li D, He S, Wang H, et al. Reduced production of laminin by hepatic stellate cells contributes to impairment in oval cell response to liver injury in aged mice. Aging (Albany NY). 2018;10:3713-3735 pubmed publisher
Kim Y, Seo D, Lee S, Lee S, An G, Ahn H, et al. Conditioned media from human umbilical cord blood-derived mesenchymal stem cells stimulate rejuvenation function in human skin. Biochem Biophys Rep. 2018;16:96-102 pubmed publisher
Sakamoto K, Kanematsu Yamaki Y, Kamada Y, Oka M, Ohnishi T, Miwa M, et al. Identification of ligand-selective peptidic ActRIIB-antagonists using phage display technology. Biochem Biophys Rep. 2017;11:33-39 pubmed publisher
De Domenico E, D Arcangelo G, Faraoni I, Palmieri M, Tancredi V, Graziani G, et al. Modulation of GDF11 expression and synaptic plasticity by age and training. Oncotarget. 2017;8:57991-58002 pubmed publisher
Chen J, Walton K, Hagg A, Colgan T, Johnson K, Qian H, et al. Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease. Proc Natl Acad Sci U S A. 2017;114:E5266-E5275 pubmed publisher
Zhao Y, Liu G, Zambito F, Zhang Y, Desilva B, Kozhich A, et al. A multiplexed immunocapture liquid chromatography tandem mass spectrometry assay for the simultaneous measurement of myostatin and GDF-11 in rat serum using an automated sample preparation platform. Anal Chim Acta. 2017;979:36-44 pubmed publisher
Jing Y, Li D, Wu F, Gong L, Li R. GDF11 does not improve the palmitate induced insulin resistance in C2C12. Eur Rev Med Pharmacol Sci. 2017;21:1795-1802 pubmed
Latres E, Mastaitis J, Fury W, Miloscio L, Trejos J, Pangilinan J, et al. Activin A more prominently regulates muscle mass in primates than does GDF8. Nat Commun. 2017;8:15153 pubmed publisher
Mata Miranda M, Vazquez Zapien G, Rojas Lopez M, Sánchez Monroy V, Pérez Ishiwara D, Delgado Macuil R. Morphological, molecular and FTIR spectroscopic analysis during the differentiation of kidney cells from pluripotent stem cells. Biol Res. 2017;50:14 pubmed publisher
Lee S, Park S, Kim Y. Maltose binding protein-fusion enhances the bioactivity of truncated forms of pig myostatin propeptide produced in E. coli. PLoS ONE. 2017;12:e0174956 pubmed publisher
Hammers D, Merscham Banda M, Hsiao J, ENGST S, Hartman J, Sweeney H. Supraphysiological levels of GDF11 induce striated muscle atrophy. EMBO Mol Med. 2017;9:531-544 pubmed publisher
Walker R, Czepnik M, Goebel E, McCoy J, Vujic A, Cho M, et al. Structural basis for potency differences between GDF8 and GDF11. BMC Biol. 2017;15:19 pubmed publisher
Latres E, Pangilinan J, Miloscio L, Bauerlein R, Na E, Potocky T, et al. Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice. Skelet Muscle. 2015;5:34 pubmed publisher
Dussiot M, Maciel T, Fricot A, Chartier C, Negre O, Veiga J, et al. An activin receptor IIA ligand trap corrects ineffective erythropoiesis in ?-thalassemia. Nat Med. 2014;20:398-407 pubmed publisher
Carrancio S, Markovics J, Wong P, Leisten J, Castiglioni P, Groza M, et al. An activin receptor IIA ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin. Br J Haematol. 2014;165:870-82 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Hocking J, Hehr C, Chang R, Johnston J, McFarlane S. TGFbeta ligands promote the initiation of retinal ganglion cell dendrites in vitro and in vivo. Mol Cell Neurosci. 2008;37:247-60 pubmed
product information
brand :
R&D Systems
master code :
1958-GD
SKU :
1958-GD-010
product name :
Recombinant Human/Mouse/Rat GDF-11/BMP-11 Protein
unit size :
10 ug
seo description :
The Recombinant Human/Mouse/Rat GDF-11/BMP-11 Protein from R&D Systems is derived from E. coli. The Recombinant Human/Mouse/Rat GDF-11/BMP-11 Protein has been validated for the following applications: Bioactivity.
target :
GDF-11/BMP-11
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human, Mouse, Rat
theoretical molecular weight :
12.6 kDa (monomer)
gene symbol :
GDF11
details of functionality :
Measured by its ability to induce hemoglobin expression in K562 human chronic myelogenous leukemia cells. Schwall, R.H. etáal . (1991) Method Enzymol. 198 :340. The ED50 for this effect is 0.8-4.8 ng/mL.
endotoxin note :
<0.01 EU per 1 ╡g of the protein by the LAL method.
top caption :
Graph showing bioactivity of GDF-11 protein
accessionNumbers :
O95390
applications :
Bioactivity
source :
E. coli-derived Recombinant Human/Mouse/Rat GDF-11/BMP-11 Protein
USD :
400 USD
alt names :
BMP11, BMP-11, BMP-11BMP11Bone morphogenetic protein 11, GDF11, GDF-11, growth differentiation factor 11, growth/differentiation factor 11
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.