Recombinant Human Crossveinless-2 Protein | R&D Systems 1956-CV-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Crossveinless-2 Protein

catalog :

1956-CV-050

quantity :

50 ug

price :

578 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Esser J, Steiner R, Deckler M, Schmitt H, Engert B, Link S, et al. Extracellular bone morphogenetic protein modulator BMPER and twisted gastrulation homolog 1 preserve arterial-venous specification in zebrafish blood vessel development and regulate Notch signaling in endothelial cells. FEBS J. 2018;285:1419-1436 pubmed publisher
Kempf H, Olmer R, Haase A, Franke A, Bolesani E, Schwanke K, et al. Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells. Nat Commun. 2016;7:13602 pubmed publisher
Olsen O, Wader K, Misund K, Våtsveen T, Rø T, Mylin A, et al. Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin. Blood Cancer J. 2014;4:e196 pubmed publisher
Satomi Kobayashi S, Kinugasa M, Kobayashi R, Hatakeyama K, Kurogane Y, Ishida T, et al. Osteoblast-like differentiation of cultured human coronary artery smooth muscle cells by bone morphogenetic protein endothelial cell precursor-derived regulator (BMPER). J Biol Chem. 2012;287:30336-45 pubmed publisher
Yao Y, Jumabay M, Ly A, Radparvar M, Wang A, Abdmaulen R, et al. Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium. Blood. 2012;119:5037-47 pubmed publisher
Helbing T, Rothweiler R, Ketterer E, Goetz L, Heinke J, Grundmann S, et al. BMP activity controlled by BMPER regulates the proinflammatory phenotype of endothelium. Blood. 2011;118:5040-9 pubmed publisher

product information

brand :

R&D Systems

master code :

1956-CV

SKU :

1956-CV-050

product name :

Recombinant Human Crossveinless-2 Protein

unit size :

50 ug

seo description :

The Recombinant Human Crossveinless-2 Protein from R&D Systems is derived from NS0. The Recombinant Human Crossveinless-2 Protein has been validated for the following applications: Bioactivity.

target :

Crossveinless-2/CV-2

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

50-55 kDa doublet and 39 kDa, reducing conditions

gene symbol :

BMPER

details of functionality :

Measured by its ability to inhibit rhBMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Binnerts, M.E. et al . (2004) Biochem. Biophys. Res. Commun. 315 :272. The ED50 for this effect is 0.2-1.6 ╡g/mL in the presence of 30 ng/mL of Recombinant Human BMP-4 (Catalog # 314-BP ).

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q8N8U9

applications :

Bioactivity

source :

NS0-derived Recombinant Human Crossveinless-2 Protein

USD :

578 USD

alt names :

BMP binding endothelial regulator, BMP-binding endothelial regulator precursor protein, BMP-binding endothelial regulator protein, BMPER, Bone morphogenetic protein-binding endothelial cell precursor-derived regulator, CRIM3, crossveinless 2, crossveinless-2, Cv2, CV-2, hCV2, KIAA1965, Protein crossveinless-2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage