Recombinant Mouse Frizzled-4 Fc Chimera Protein, CF | R&D Systems 194-FZ-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Frizzled-4 Fc Chimera Protein, CF

catalog :

194-FZ-050

quantity :

50 ug

price :

456 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Zhang Y, Wang Y, Zheng G, Liu Y, Li J, Huang H, et al. Follistatin-like 1 (FSTL1) interacts with Wnt ligands and Frizzled receptors to enhance Wnt/β-catenin signaling in obstructed kidneys in vivo. J Biol Chem. 2022;298:102010 pubmed publisher
Magdesian M, Carvalho M, Mendes F, Saraiva L, Juliano M, Juliano L, et al. Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling. J Biol Chem. 2008;283:9359-68 pubmed publisher
Masckauchan T, Agalliu D, Vorontchikhina M, Ahn A, Parmalee N, Li C, et al. Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2. Mol Biol Cell. 2006;17:5163-72 pubmed

product information

master code :

194-FZ

SKU :

194-FZ-050

product name :

Recombinant Mouse Frizzled-4 Fc Chimera Protein, CF

unit size :

50 ug

description :

The Recombinant Mouse Frizzled-4 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse Frizzled-4 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

Frizzled-4

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

50-55 kDa, reducing conditions

theoretical molecular weight :

43 kDa (monomer)

gene symbol :

Fzd4

details of functionality :

Measured by its ability to bind biotinylated rmWnt-5a in a functional ELISA with an estimated KD 5 nM.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q8BLL2

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived mouse Frizzled-4 protein Frizzled-4 (Phe37-Glu180) Accession # Q8BLL2 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

source short :

NS0

USD :

456 USD

alt names :

CD344, CD344 antigen, EVR1, exudative vitreoretinopathy 1, FEVR, frizzled (Drosophila) homolog 4, frizzled homolog 4 (Drosophila), frizzled-4, Frizzled4, Fz-4, FZD4, FZD4S, FzE4, GPCR, hFz4, MGC34390, WNT receptor frizzled-4

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage