Human alpha 2-Macroglobulin Protein, CF | R&D Systems 1938-PI product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Human alpha 2-Macroglobulin Protein, CF

catalog :

1938-PI

quantity :

50 ug

price :

159 USD

citations: 4

Reference
Bakhtyar N, Jeschke M, Herer E, Sheikholeslam M, Amini Nik S. Exosomes from acellular Wharton's jelly of the human umbilical cord promotes skin wound healing. Stem Cell Res Ther. 2018;9:193 pubmed publisher
Yi K, Jung S, Cho G, Seol H, Hong S, Oh M, et al. Effects of sFlt-1 and alpha 2-macroglobulin on vascular endothelial growth factor-induced endothelin-1 upregulation in human microvascular endothelial cells. Placenta. 2014;35:64-9 pubmed publisher
Krstic D, Rodríguez M, Knuesel I. Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators. PLoS ONE. 2012;7:e47793 pubmed publisher
Memari N, Jiang W, Diamandis E, Luo L. Enzymatic properties of human kallikrein-related peptidase 12 (KLK12). Biol Chem. 2007;388:427-35 pubmed

product information

brand :

R&D Systems

master code :

1938-PI

SKU :

1938-PI-050

product name :

Human alpha 2-Macroglobulin Protein, CF

description :

The Human alpha 2-Macroglobulin Protein, CF from R&D Systems is derived from Human Plasma. The Human alpha 2-Macroglobulin Protein, CF has been validated for the following applications: Inhibition Activity.

target :

alpha 2-Macroglobulin

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Supplied as a 0.2 µm filtered solution in NaH2PO4, NaCl and Glycerol.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

90-170 kDa, reducing conditions

gene symbol :

A2M

details of functionality :

Measured by its ability to trap trypsin. The trapped trypsin is no longer able to interact with protein substrates or inhibitors, but still able to cleave small peptide substrates or inhibitors. Human alpha 2-Macroglobulin has an IC50 value of 5 nM, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

1938-PI

applications :

Inhibition Activity

source :

Human plasma-derived alpha 2-Macroglobulin protein The human plasma used for the isolation of this product was certified by the supplier to be HIV-1 and HBsAg negative at the time of shipment. Human blood products should always be treated in accordance with universal handling precautions.

2020 USD :

159

2021 USD :

159 USD

alt names :

A2M, alpha 2Macroglobulin, Alpha-2-M, alpha-2-macroglobulin, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, CPAMD5, CPAMD5DKFZp779B086, FWP007, S863-7

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.