Human alpha 2-Macroglobulin Protein, CF | R&D Systems 1938-PI-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Human alpha 2-Macroglobulin Protein, CF

catalog :

1938-PI-050

quantity :

50 ug

price :

203 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Santamaria S, Martin D, Dong X, Yamamoto K, Apte S, Ahnstr xf6 m J. Post-translational regulation and proteolytic activity of the metalloproteinase ADAMTS8. J Biol Chem. 2021;297:101323 pubmed publisher
Bakhtyar N, Jeschke M, Herer E, Sheikholeslam M, Amini Nik S. Exosomes from acellular Wharton's jelly of the human umbilical cord promotes skin wound healing. Stem Cell Res Ther. 2018;9:193 pubmed publisher
Yi K, Jung S, Cho G, Seol H, Hong S, Oh M, et al. Effects of sFlt-1 and alpha 2-macroglobulin on vascular endothelial growth factor-induced endothelin-1 upregulation in human microvascular endothelial cells. Placenta. 2014;35:64-9 pubmed publisher
Krstic D, Rodríguez M, Knuesel I. Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators. PLoS ONE. 2012;7:e47793 pubmed publisher
Memari N, Jiang W, Diamandis E, Luo L. Enzymatic properties of human kallikrein-related peptidase 12 (KLK12). Biol Chem. 2007;388:427-35 pubmed

product information

brand :

R&D Systems

master code :

1938-PI

SKU :

1938-PI-050

product name :

Human alpha 2-Macroglobulin Protein, CF

unit size :

50 ug

seo description :

The Human alpha 2-Macroglobulin Protein, CF from R&D Systems is derived from Human Plasma. The Human alpha 2-Macroglobulin Protein, CF has been validated for the following applications: Inhibition Activity.

target :

alpha 2-Macroglobulin

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in NaH2PO4, NaCl and Glycerol.

conjugate :

Unconjugated

dilution :

Inhibition Activity

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

90-170 kDa, reducing conditions

gene symbol :

A2M

details of functionality :

Measured by its ability to trap trypsin. The trapped trypsin is no longer able to interact with protein substrates or inhibitors, but still able to cleave small peptide substrates or inhibitors. Human alpha 2-Macroglobulin has an IC50 value of 5 nM, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

applications :

Inhibition Activity

source :

Human Plasma

USD :

203 USD

alt names :

A2M, alpha 2Macroglobulin, Alpha-2-M, alpha-2-macroglobulin, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, CPAMD5, CPAMD5DKFZp779B086, FWP007, S863-7

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.

more info or order :

R&D Systems product webpage