Recombinant Mouse TL1A/TNFSF15 Protein | R&D Systems 1896-TL-010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse TL1A/TNFSF15 Protein

catalog :

1896-TL-010

quantity :

10 ug

price :

432 USD

citations: 17

Reference
Liu X, Zhang J, Zhang D, Pan Y, Zeng R, Xu C, et al. Necroptosis plays a role in TL1A-induced airway inflammation and barrier damage in asthma. Respir Res. 2024;25:271 pubmed publisher
Jacob N, Kumagai K, Abraham J, Shimodaira Y, Ye Y, Luu J, et al. Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo. Sci Rep. 2020;10:18189 pubmed publisher
Jacob N, Jacobs J, Kumagai K, Ha C, Kanazawa Y, Lagishetty V, et al. Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome. Mucosal Immunol. 2018;11:1466-1476 pubmed publisher
Ferdinand J, Richard A, Meylan F, Al Shamkhani A, Siegel R. Cleavage of TL1A Differentially Regulates Its Effects on Innate and Adaptive Immune Cells. J Immunol. 2018;200:1360-1369 pubmed publisher
Zhao Y, Chu X, Chen J, Wang Y, Gao S, Jiang Y, et al. Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells. Nat Commun. 2016;7:12368 pubmed publisher
Jia L, Bamias G, Arseneau K, Burkly L, Wang E, Gruszka D, et al. A Novel Role for TL1A/DR3 in Protection against Intestinal Injury and Infection. J Immunol. 2016;197:377-86 pubmed publisher
Holmkvist P, Pool L, Hägerbrand K, Agace W, Rivollier A. IL-18R?-deficient CD4(+) T cells induce intestinal inflammation in the CD45RB(hi) transfer model of colitis despite impaired innate responsiveness. Eur J Immunol. 2016;46:1371-82 pubmed publisher
Gomez Rodriguez J, Meylan F, Handon R, Hayes E, Anderson S, Kirby M, et al. Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4. Nat Commun. 2016;7:10857 pubmed publisher
Longman R, Diehl G, Victorio D, Huh J, Galan C, Miraldi E, et al. CX?CR1? mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. J Exp Med. 2014;211:1571-83 pubmed publisher
Yu X, Pappu R, Ramirez Carrozzi V, Ota N, Caplazi P, Zhang J, et al. TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers. Mucosal Immunol. 2014;7:730-40 pubmed publisher
Wang X, Hu Y, Charpentier T, Lamarre A, Qi S, Wu J, et al. TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: implication of TL1A in humoral immune responses. J Immunol. 2013;191:5420-9 pubmed publisher
Freeman B, Hammarlund E, Raué H, Slifka M. Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A. 2012;109:9971-6 pubmed publisher
Twohig J, Marsden M, Cuff S, Ferdinand J, Gallimore A, Perks W, et al. The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4? and CD8? T-cell immunity. FASEB J. 2012;26:3575-86 pubmed publisher
Jones G, Stumhofer J, Foster T, Twohig J, Hertzog P, Topley N, et al. Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. FASEB J. 2011;25:409-19 pubmed publisher
Kayamuro H, Yoshioka Y, Abe Y, Katayama K, Yoshida T, Yamashita K, et al. TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant. Biochem Biophys Res Commun. 2009;384:296-300 pubmed publisher
Mueller A, Pedre X, Killian S, David M, Steinbrecher A. The Decoy Receptor 3 (DcR3, TNFRSF6B) suppresses Th17 immune responses and is abundant in human cerebrospinal fluid. J Neuroimmunol. 2009;209:57-64 pubmed publisher
Kim M, Rossi S, Withers D, McConnell F, Toellner K, Gaspal F, et al. Heterogeneity of lymphoid tissue inducer cell populations present in embryonic and adult mouse lymphoid tissues. Immunology. 2008;124:166-74 pubmed publisher

product information

master code :

1896-TL

SKU :

1896-TL-010

product name :

Recombinant Mouse TL1A/TNFSF15 Protein

unit size :

10 ug

description :

The Recombinant Mouse TL1A/TNFSF15 Protein from R&D Systems is derived from E. coli. The Recombinant Mouse TL1A/TNFSF15 Protein has been validated for the following applications: Bioactivity.

target :

TL1A/TNFSF15

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Mouse

theoretical molecular weight :

20 kDa

gene symbol :

Tnfsf15

details of functionality :

Measured by its ability to induce apoptosis of TF-1 human erythroleukemic cells. Migone, T. et al . (2002) Immunity 16 :479. The ED50 for this effect is 15-75 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAM77367

applications :

Bioactivity

source long :

E. coli -derived mouse TL1A/TNFSF15 protein Ile76-Leu252, with an N-terminal Met

source short :

E. coli

USD :

432 USD

alt names :

MGC129934, MGC129935, TL1A, TL1Vascular endothelial cell growth inhibitor, TNF superfamily ligand TL1A, TNFSF15, tumor necrosis factor (ligand) superfamily, member 15, tumor necrosis factor ligand superfamily member 15, vascular endothelial growth inhibitor-192A, VEGI, VEGI192A, VEGITNF ligand-related molecule 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.