Recombinant Human Active SHP-2 Protein, CF | R&D Systems 1894-SH product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Active SHP-2 Protein, CF

catalog :

1894-SH

quantity :

1 mg

price :

3023 USD

citations: 4

Reference
Fan Z, Tian Y, Chen Z, Liu L, Zhou Q, He J, et al. Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors. EMBO Mol Med. 2020;12:e11571 pubmed publisher
Zehender A, Huang J, Györfi A, Matei A, Trinh Minh T, Xu X, et al. The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis. Nat Commun. 2018;9:3259 pubmed publisher
Craig J, Mikhailenko I, Noyes N, Migliorini M, Strickland D. The LDL receptor-related protein 1 (LRP1) regulates the PDGF signaling pathway by binding the protein phosphatase SHP-2 and modulating SHP-2- mediated PDGF signaling events. PLoS ONE. 2013;8:e70432 pubmed publisher
Zang Q, Martinez B, Yao X, Maass D, Ma L, Wolf S, et al. Sepsis-induced cardiac mitochondrial dysfunction involves altered mitochondrial-localization of tyrosine kinase Src and tyrosine phosphatase SHP2. PLoS ONE. 2012;7:e43424 pubmed publisher

product information

brand :

R&D Systems

master code :

1894-SH

SKU :

1894-SH-01M

product name :

Recombinant Human Active SHP-2 Protein, CF

description :

The Recombinant Human Active SHP-2 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human Active SHP-2 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

SHP-2/PTPN11

category :

Proteins and Enzymes

unit size :

1 mg

buffer :

Supplied as a 0.2 µm filtered solution in Tris, NaCl, Glycerol and DTT.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

63-70 kDa, reducing conditions

theoretical molecular weight :

69 kDa

gene symbol :

PTPN11

details of functionality :

Measured by its ability to dephosphorylate a tyrosine residue in a peptide containing the EGFR Y992 phosphorylation site (Catalog # ES006 ). The specific activity is 3 µmol/min/mg, measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

1894-SH

accessionNumbers :

NP_002825.3

applications :

Enzyme Activity

source :

E. coli -derived human SHP-2 protein Thr2-Arg593, with an N-terminal 6-His tag

2020 USD :

3023

2021 USD :

3023 USD

alt names :

BPTP3, EC 3.1.3.48, MGC14433, protein tyrosine phosphatase, non-receptor type 11, protein tyrosine phosphatase-2, Protein-tyrosine phosphatase 1D, Protein-tyrosine phosphatase 2C, PTP1D, PTP-1D, PTP2C, PTP-2C, PTP2CNS1, PTPN11, SHP2, SHP-2, SHP2CFC, SHPTP2, SH-PTP2, SH-PTP2Noonan syndrome 1, SH-PTP3, tyrosine-protein phosphatase non-receptor type 11

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening.