Recombinant Human Active SHP-2 Protein, CF | R&D Systems 1894-SH-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Active SHP-2 Protein, CF

catalog :

1894-SH-100

quantity :

100 ug (also 1 mg)

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Liu W, Zhao J, Guo X, Lu S, Li W, Li W. Design, synthesis, activity and molecular dynamics studies of 1,3,4-thiadiazole derivatives as selective allosteric inhibitors of SHP2 for the treatment of cancer. Eur J Med Chem. 2023;258:115585 pubmed publisher
Solanki A, Arif E, Srivastava P, Furcht C, Rahman B, Wen P, et al. Phosphorylation of slit diaphragm proteins NEPHRIN and NEPH1 upon binding of HGF promotes podocyte repair. J Biol Chem. 2021;297:101079 pubmed publisher
Fan Z, Tian Y, Chen Z, Liu L, Zhou Q, He J, et al. Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors. EMBO Mol Med. 2020;12:e11571 pubmed publisher
Zehender A, Huang J, Györfi A, Matei A, Trinh Minh T, Xu X, et al. The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis. Nat Commun. 2018;9:3259 pubmed publisher
Zang Q, Martinez B, Yao X, Maass D, Ma L, Wolf S, et al. Sepsis-induced cardiac mitochondrial dysfunction involves altered mitochondrial-localization of tyrosine kinase Src and tyrosine phosphatase SHP2. PLoS ONE. 2012;7:e43424 pubmed publisher

product information

brand :

R&D Systems

master code :

1894-SH

SKU :

1894-SH-100

product name :

Recombinant Human Active SHP-2 Protein, CF

unit size :

100 ug (also 1 mg)

seo description :

The Recombinant Human Active SHP-2 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human Active SHP-2 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

SHP-2

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in Tris, NaCl, Glycerol and DTT.

conjugate :

Unconjugated

dilution :

Enzyme Activity

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

63-70 kDa, reducing conditions

theoretical molecular weight :

69 kDa

gene symbol :

PTPN11

details of functionality :

Measured by its ability to dephosphorylate a tyrosine residue in a peptide containing the EGFR Y992 phosphorylation site (Catalog # ES006 ). The specific activity is 3 ╡mol/min/mg, measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

NP_002825.3

applications :

Enzyme Activity

source :

E. coli-derived Recombinant Human Active SHP-2 Protein, CF

USD :

432 USD

alt names :

BPTP3, EC 3.1.3.48, MGC14433, protein tyrosine phosphatase, non-receptor type 11, protein tyrosine phosphatase-2, Protein-tyrosine phosphatase 1D, Protein-tyrosine phosphatase 2C, PTP1D, PTP-1D, PTP2C, PTP-2C, PTP2CNS1, PTPN11, SHP2, SHP-2, SHP2CFC, SHPTP2, SH-PTP2, SH-PTP2Noonan syndrome 1, SH-PTP3, tyrosine-protein phosphatase non-receptor type 11

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 ░C as supplied. 3 months, -70 ░C under sterile conditions after opening.

more info or order :

R&D Systems product webpage