This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IL-23 Protein, CF
catalog :
1887-ML-010/CF
quantity :
10 ug
price :
435 USD
citations: 179
Reference
Yang W, Qiu W, Zhang T, Xu K, Gu Z, Zhou Y, et al. Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis. Nat Commun. 2023;14:863 pubmed publisher
Huu Hoang T, Sato Matsubara M, Yuasa H, Matsubara T, Thuy L, Ikenaga H, et al. Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms. Sci Adv. 2022;8:eabo5525 pubmed publisher
Millet N, Solis N, Aguilar D, Lionakis M, Wheeler R, Jendzjowsky N, et al. IL-23 signaling prevents ferroptosis-driven renal immunopathology during candidiasis. Nat Commun. 2022;13:5545 pubmed publisher
Rani L, Kumar A, Karhade J, Pandey G, Guha A, Mishra G, et al. IL-3 regulates the differentiation of pathogenic Th17 cells. Eur J Immunol. 2022;52:1842-1858 pubmed publisher
Nishida Tamehiro K, Kimura A, Tsubata T, Takahashi S, Suzuki H. Antioxidative enzyme NAD(P)H quinone oxidoreductase 1 (NQO1) modulates the differentiation of Th17 cells by regulating ROS levels. PLoS ONE. 2022;17:e0272090 pubmed publisher
Chen X, Jaiswal A, Costliow Z, Herbst P, Creasey E, Oshiro Rapley N, et al. pH sensing controls tissue inflammation by modulating cellular metabolism and endo-lysosomal function of immune cells. Nat Immunol. 2022;23:1063-1075 pubmed publisher
Zhang Y, Xin D, Wang Z, Peng W, Zeng Y, Liang J, et al. Acetylation licenses Th1 cell polarization to constrain Listeria monocytogenes infection. Cell Death Differ. 2022;29:2303-2315 pubmed publisher
Damasceno L, Cebinelli G, Fernandes M, Nascimento D, P xfa blio G, Vinolo M, et al. STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program. Cell Rep. 2022;39:110838 pubmed publisher
Zhang Q, Liu W, Wang H, Zhou H, Bulek K, Chen X, et al. TH17 cells promote CNS inflammation by sensing danger signals via Mincle. Nat Commun. 2022;13:2406 pubmed publisher
Cheng H, M xf6 rbe U, L xfc tge M, Engetschwiler C, Onder L, Novković M, et al. Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function. Nat Commun. 2022;13:2027 pubmed publisher
Yogev N, Bedke T, Kobayashi Y, Brockmann L, Lukas D, Regen T, et al. CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival. Cell Rep. 2022;38:110565 pubmed publisher
Wakai M, Hayashi R, Ueno Y, Onishi K, Takasago T, Uchida T, et al. Promoting mechanism of serum amyloid a family expression in mouse intestinal epithelial cells. PLoS ONE. 2022;17:e0264836 pubmed publisher
Ma S, Patel S, Abe Y, Chen N, Patel P, Cho B, et al. RORγt phosphorylation protects against T cell-mediated inflammation. Cell Rep. 2022;38:110520 pubmed publisher
Patel V, Jayaraman A, Jayaraman S. Epigenetic drug ameliorated type 1 diabetes via decreased generation of Th1 and Th17 subsets and restoration of self-tolerance in CD4+ T cells. Int Immunopharmacol. 2022;103:108490 pubmed publisher
Zhu Y, Wu Z, Yan W, Shao F, Ke B, Jiang X, et al. Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis. EMBO Mol Med. 2022;14:e14455 pubmed publisher
Gurusamy M, Tischner D, Shao J, Klatt S, Zukunft S, Bonnavion R, et al. G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators. Nat Commun. 2021;12:6798 pubmed publisher
Chi X, Jin W, Bai X, Zhao X, Shao J, Li J, et al. RORα is critical for mTORC1 activity in T cell-mediated colitis. Cell Rep. 2021;36:109682 pubmed publisher
Agasing A, Quinn J, Kumar G, Axtell R. Interferon-β Intensifies Interleukin-23-Driven Pathogenicity of T Helper Cells in Neuroinflammatory Disease. Cells. 2021;10: pubmed publisher
Zhou J, Zhang X, Hu J, Qu R, Yu Z, Xu H, et al. m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity. Sci Adv. 2021;7: pubmed publisher
Chen E, Lee C, Thompson P, Wiest D, Anderson M, Zuniga Pflucker J. Ontogenic timing, T cell receptor signal strength, and Notch signaling direct γδ T cell functional differentiation in vivo. Cell Rep. 2021;35:109227 pubmed publisher
Costa F, Leite J, Rassi D, da Silva J, Elias Oliveira J, Guimar xe3 es J, et al. NLRP1 acts as a negative regulator of Th17 cell programming in mice and humans with autoimmune diabetes. Cell Rep. 2021;35:109176 pubmed publisher
Maria Z, Turner E, Agasing A, Kumar G, Axtell R. Pertussis Toxin Inhibits Encephalitogenic T-Cell Infiltration and Promotes a B-Cell-Driven Disease during Th17-EAE. Int J Mol Sci. 2021;22: pubmed publisher
Tao H, Pan Y, Chu S, Li L, Xie J, Wang P, et al. Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals. Nat Commun. 2021;12:2029 pubmed publisher
Doss P, Umair M, Baillargeon J, Fazazi R, Fudge N, Akbar I, et al. Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity. Cell Rep. 2021;34:108833 pubmed publisher
Yabe R, Chung S, Murayama M, Kubo S, Shimizu K, Akahori Y, et al. TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens. Nat Commun. 2021;12:94 pubmed publisher
Kajino Sakamoto R, Fujishita T, Taketo M, Aoki M. Synthetic lethality between MyD88 loss and mutations in Wnt/β-catenin pathway in intestinal tumor epithelial cells. Oncogene. 2021;40:408-420 pubmed publisher
Mamareli P, Kruse F, Lu C, Guderian M, Floess S, Rox K, et al. Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection. Mucosal Immunol. 2021;14:164-176 pubmed publisher
Zhang H, Madi A, Yosef N, Chihara N, Awasthi A, Pot C, et al. An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets. Cell Rep. 2020;33:108433 pubmed publisher
Baniahmad A, Birkner K, Görg J, Loos J, Zipp F, Wasser B, et al. The frequency of follicular T helper cells differs in acute and chronic neuroinflammation. Sci Rep. 2020;10:20485 pubmed publisher
Mizoguchi I, Ohashi M, Hasegawa H, Chiba Y, Orii N, Inoue S, et al. EBV-induced gene 3 augments IL-23Rα protein expression through a chaperone calnexin. J Clin Invest. 2020;130:6124-6140 pubmed publisher
Liu Y, Bockermann R, Hadi M, Safari I, Carrion B, Kveiborg M, et al. ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation. Cell Mol Immunol. 2020;: pubmed publisher
Agasing A, Wu Q, Khatri B, Borisow N, Ruprecht K, Brandt A, et al. Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica. Nat Commun. 2020;11:2856 pubmed publisher
Lee K, Zhang Z, Achuthan A, Fleetwood A, Smith J, Hamilton J, et al. IL-23 in arthritic and inflammatory pain development in mice. Arthritis Res Ther. 2020;22:123 pubmed publisher
Morelli A, Sumpter T, Rojas Canales D, Bandyopadhyay M, Chen Z, Tkacheva O, et al. Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells. Cell Rep. 2020;30:3448-3465.e8 pubmed publisher
Singh A, Dashnyam M, Chim B, Escobar T, Dulcey A, Hu X, et al. Anxiolytic Drug FGIN-1-27 Ameliorates Autoimmunity by Metabolic Reprogramming of Pathogenic Th17 Cells. Sci Rep. 2020;10:3766 pubmed publisher
Liu D, Xing S, Wang W, Huang X, Lin H, Chen Y, et al. Prognostic value of serum soluble interleukin-23 receptor and related T-helper 17 cell cytokines in non-small cell lung carcinoma. Cancer Sci. 2020;111:1093-1102 pubmed publisher
Raphael I, Gomez Rivera F, Raphael R, Robinson R, Nalawade S, Forsthuber T. TNFR2 limits proinflammatory astrocyte functions during EAE induced by pathogenic DR2b-restricted T cells. JCI Insight. 2019;4: pubmed publisher
Razawy W, Asmawidjaja P, Mus A, Salioska N, Davelaar N, Kops N, et al. CD4+ CCR6+ T cells, but not γδ T cells, are important for the IL-23R-dependent progression of antigen-induced inflammatory arthritis in mice. Eur J Immunol. 2020;50:245-255 pubmed publisher
Lee H, Kim L, Choi J. NFAT-Specific Inhibition by dNP2-VIVITAmeliorates Autoimmune Encephalomyelitisby Regulation of Th1 and Th17. Mol Ther Methods Clin Dev. 2020;16:32-41 pubmed publisher
Radulovic K, Ayata C, Mak Anyengo R, Lechner K, Wuggenig P, Kaya B, et al. NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death. J Immunol. 2019;: pubmed publisher
Kawalkowska J, Ogbechi J, Venables P, Williams R. cIAP1/2 inhibition synergizes with TNF inhibition in autoimmunity by down-regulating IL-17A and inducing Tregs. Sci Adv. 2019;5:eaaw5422 pubmed publisher
Abdullah A, Maged M, Hairul Islam M I, Osama I A, Maha H, Manal A, et al. Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis. PLoS ONE. 2019;14:e0215981 pubmed publisher
Okunuki Y, Mukai R, Nakao T, Tabor S, Butovsky O, Dana R, et al. Retinal microglia initiate neuroinflammation in ocular autoimmunity. Proc Natl Acad Sci U S A. 2019;116:9989-9998 pubmed publisher
Katsura H, Kobayashi Y, Tata P, Hogan B. IL-1 and TNFα Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration. Stem Cell Reports. 2019;12:657-666 pubmed publisher
Liu Y, Song Y, Lin D, Lei L, Mei Y, Jin Z, et al. NCR- group 3 innate lymphoid cells orchestrate IL-23/IL-17 axis to promote hepatocellular carcinoma development. EBioMedicine. 2019;41:333-344 pubmed publisher
Lee H, Lee J, Kim D, Lim S, Kang I, Choi J. Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis. Nat Commun. 2019;10:709 pubmed publisher
Graham K, Werner B, Moyer K, Patton A, Krois C, Yoo H, et al. DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2019;116:3126-3135 pubmed publisher
Yasuda K, Kitagawa Y, Kawakami R, Isaka Y, Watanabe H, Kondoh G, et al. Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation. Nat Commun. 2019;10:549 pubmed publisher
Amir M, Chaudhari S, Wang R, Campbell S, Mosure S, Chopp L, et al. REV-ERBα Regulates TH17 Cell Development and Autoimmunity. Cell Rep. 2018;25:3733-3749.e8 pubmed publisher
Bamidele A, Svingen P, Sagstetter M, Sarmento O, González M, Braga Neto M, et al. Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation. Cell Mol Gastroenterol Hepatol. 2019;7:55-71 pubmed publisher
de Lima K, Donate P, Talbot J, Davoli Ferreira M, Peres R, Cunha T, et al. TGFβ1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of TH17 cells by an AHR-independent mechanism. Cell Death Dis. 2018;9:1130 pubmed publisher
Zhang C, Jiang M, Zhou H, Liu W, Wang C, Kang Z, et al. TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation. J Clin Invest. 2018;128:5399-5412 pubmed publisher
Berger C, Crepin V, Roumeliotis T, Wright J, Serafini N, Pevsner Fischer M, et al. The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses. PLoS Pathog. 2018;14:e1007406 pubmed publisher
Chuang H, Tsai C, Hsueh C, Tan T. GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease. Sci Adv. 2018;4:eaat5401 pubmed publisher
Breuer J, Korpos E, Hannocks M, Schneider Hohendorf T, Song J, Zondler L, et al. Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus. J Neuroinflammation. 2018;15:236 pubmed publisher
Bouchareychas L, Grössinger E, Kang M, Adamopoulos I. ??TCR regulates production of interleukin-27 by neutrophils and attenuates inflammatory arthritis. Sci Rep. 2018;8:7590 pubmed publisher
Ngo V, Abo H, Maxim E, Harusato A, Geem D, Medina Contreras O, et al. A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage. Proc Natl Acad Sci U S A. 2018;115:E5076-E5085 pubmed publisher
Wu R, Zeng J, Yuan J, Deng X, Huang Y, Chen L, et al. MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation. J Clin Invest. 2018;128:2551-2568 pubmed publisher
Jiang Y, Liu Y, Lu H, Sun S, Jin W, Wang X, et al. Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28. Nat Commun. 2018;9:1424 pubmed publisher
Meyer zu Horste G, Przybylski D, Schramm M, Wang C, Schnell A, Lee Y, et al. Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1. Immunity. 2018;48:556-569.e7 pubmed publisher
Mikami Y, Scarno G, Zitti B, Shih H, Kanno Y, Santoni A, et al. NCR+ ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice. Eur J Immunol. 2018;48:1174-1180 pubmed publisher
Suto H, Nambu A, Morita H, Yamaguchi S, Numata T, Yoshizaki T, et al. IL-25 enhances TH17 cell-mediated contact dermatitis by promoting IL-1β production by dermal dendritic cells. J Allergy Clin Immunol. 2018;142:1500-1509.e10 pubmed publisher
Hou Y, Zhu L, Tian H, Sun H, Wang R, Zhang L, et al. IL-23-induced macrophage polarization and its pathological roles in mice with imiquimod-induced psoriasis. Protein Cell. 2018;9:1027-1038 pubmed publisher
Sun B, Zhu L, Tao Y, Sun H, Li Y, Wang P, et al. Characterization and allergic role of IL-33-induced neutrophil polarization. Cell Mol Immunol. 2018;15:782-793 pubmed publisher
St Leger A, Hansen A, Karauzum H, Horai R, Yu C, Laurence A, et al. STAT-3-independent production of IL-17 by mouse innate-like αβ T cells controls ocular infection. J Exp Med. 2018;215:1079-1090 pubmed publisher
Emgård J, Kammoun H, García Cassani B, Chesne J, Parigi S, Jacob J, et al. Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation. Immunity. 2018;48:120-132.e8 pubmed publisher
Duncker P, Stoolman J, Huber A, Segal B. GM-CSF Promotes Chronic Disability in Experimental Autoimmune Encephalomyelitis by Altering the Composition of Central Nervous System-Infiltrating Cells, but Is Dispensable for Disease Induction. J Immunol. 2018;200:966-973 pubmed publisher
He T, Huang Y, Zhang C, Liu D, Cheng C, Xu W, et al. Interleukin-17A-promoted MSC2 polarization related with new bone formation of ankylosing spondylitis. Oncotarget. 2017;8:96993-97008 pubmed publisher
Purvis H, Clarke F, Jordan C, Blanco C, Cornish G, Dai X, et al. Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice. Eur J Immunol. 2018;48:306-315 pubmed publisher
Muschaweckh A, Petermann F, Korn T. IL-1? and IL-23 Promote Extrathymic Commitment of CD27+CD122- ?? T Cells to ??T17 Cells. J Immunol. 2017;199:2668-2679 pubmed publisher
Arima Y, Ohki T, Nishikawa N, Higuchi K, Ota M, Tanaka Y, et al. Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit. elife. 2017;6: pubmed publisher
Savage A, Liang H, Locksley R. The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine. J Immunol. 2017;199:1912-1922 pubmed publisher
Carson W, Cavassani K, Soares E, Hirai S, Kittan N, Schaller M, et al. The STAT4/MLL1 Epigenetic Axis Regulates the Antimicrobial Functions of Murine Macrophages. J Immunol. 2017;199:1865-1874 pubmed publisher
Pan W, Hao W, Shen Y, Li X, Wang Y, Sun F, et al. The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells. Parasit Vectors. 2017;10:348 pubmed publisher
Aki A, Nagasaki M, Malynn B, Ma A, Kagari T. Hypomorphic A20 expression confers susceptibility to psoriasis. PLoS ONE. 2017;12:e0180481 pubmed publisher
Dai H, He F, Tsokos G, Kyttaris V. IL-23 Limits the Production of IL-2 and Promotes Autoimmunity in Lupus. J Immunol. 2017;199:903-910 pubmed publisher
Kim S, Cho B, Kiyono H, Jang Y. Microbiota-derived butyrate suppresses group 3 innate lymphoid cells in terminal ileal Peyer's patches. Sci Rep. 2017;7:3980 pubmed publisher
Thu Le H, Nakamura Y, Oh oka K, Ishimaru K, Nakajima S, Nakao A. The frequency of Th17 cells in the small intestine exhibits a day-night variation dependent on circadian clock activity. Biochem Biophys Res Commun. 2017;490:290-295 pubmed publisher
Montoya M, Maul J, Singh P, Pua H, Dahlström F, Wu N, et al. A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation. J Immunol. 2017;199:559-569 pubmed publisher
Yang H, Guo H, Li X, Lin J, Zhang W, Zhao J, et al. Viral RNA-Unprimed Rig-I Restrains Stat3 Activation in the Modulation of Regulatory T Cell/Th17 Cell Balance. J Immunol. 2017;199:119-128 pubmed publisher
Zhao Q, Harbour S, Kolde R, Latorre I, Tun H, Schoeb T, et al. Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota. J Immunol. 2017;199:312-322 pubmed publisher
Pierson E, GOVERMAN J. GM-CSF is not essential for experimental autoimmune encephalomyelitis but promotes brain-targeted disease. JCI Insight. 2017;2:e92362 pubmed publisher
Fu G, Xu Q, Qiu Y, Jin X, Xu T, Dong S, et al. Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1. J Exp Med. 2017;214:1453-1469 pubmed publisher
Lino C, Barros Martins J, Oberdörfer L, Walzer T, Prinz I. Eomes expression reports the progressive differentiation of IFN-?-producing Th1-like ?? T cells. Eur J Immunol. 2017;47:970-981 pubmed publisher
Zhu H, Lou F, Yin Q, Gao Y, Sun Y, Bai J, et al. RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease. EMBO Mol Med. 2017;9:589-604 pubmed publisher
Downs Canner S, Berkey S, Delgoffe G, Edwards R, Curiel T, Odunsi K, et al. Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells. Nat Commun. 2017;8:14649 pubmed publisher
Franchi L, Monteleone I, Hao L, Spahr M, Zhao W, Liu X, et al. Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis. J Immunol. 2017;198:2735-2746 pubmed publisher
Hao Z, Sheng Y, Duncan G, Li W, Dominguez C, Sylvester J, et al. K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression. Nat Commun. 2017;8:14003 pubmed publisher
Lécuyer M, Saint Laurent O, Bourbonnière L, Larouche S, Larochelle C, Michel L, et al. Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis. Proc Natl Acad Sci U S A. 2017;114:E524-E533 pubmed publisher
Layman A, Sprout S, Phillips D, Oliver P. Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production. Sci Rep. 2017;7:39649 pubmed publisher
Xue X, Soroosh P, De Leon Tabaldo A, Luna Roman R, Sablad M, Rozenkrants N, et al. Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis. Sci Rep. 2016;6:37977 pubmed publisher
Ippagunta S, Gangwar R, Finkelstein D, Vogel P, Pelletier S, Gingras S, et al. Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function. Proc Natl Acad Sci U S A. 2016;113:E6162-E6171 pubmed
Way E, Trevejo Nuñez G, Kane L, Steiner B, Puri K, Kolls J, et al. Dose-Dependent Suppression of Cytokine production from T cells by a Novel Phosphoinositide 3-Kinase Delta Inhibitor. Sci Rep. 2016;6:30384 pubmed publisher
Michel M, Lenoir C, Massot B, Diem S, Pasquier B, Sawa S, et al. SLAM-associated protein favors the development of iNKT2 over iNKT17 cells. Eur J Immunol. 2016;46:2162-74 pubmed publisher
Guthrie L, Abiraman K, Plyler E, Sprenkle N, Gibson S, McFarland B, et al. Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses. J Biol Chem. 2016;291:15830-40 pubmed publisher
Zhao R, Liang D, Sun D. Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU). PLoS ONE. 2016;11:e0155953 pubmed publisher
Verrier T, Satoh Takayama N, Serafini N, Marie S, Di Santo J, Vosshenrich C. Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells. J Immunol. 2016;196:4731-8 pubmed publisher
Larabee C, Hu Y, Desai S, Georgescu C, Wren J, Axtell R, et al. Myelin-specific Th17 cells induce severe relapsing optic neuritis with irreversible loss of retinal ganglion cells in C57BL/6 mice. Mol Vis. 2016;22:332-41 pubmed
O Leary C, Riling C, Spruce L, Ding H, Kumar S, Deng G, et al. Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells. Nat Commun. 2016;7:11226 pubmed publisher
Pasi S, Kant R, Surolia A. Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response. J Biol Chem. 2016;291:12358-69 pubmed publisher
Lin C, Bradstreet T, Schwarzkopf E, Jarjour N, Chou C, Archambault A, et al. IL-1-induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation. J Exp Med. 2016;213:251-71 pubmed publisher
Lee J, Kannarkat G, Chung J, Joon Lee H, Graham K, Tansey M. RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis. J Neuroinflammation. 2016;13:24 pubmed publisher
Velázquez F, Grodecki Pena A, Knapp A, Salvador A, NEVERS T, Croce K, et al. CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo. J Immunol. 2016;196:1305-1316 pubmed publisher
Bozoyan L, Dumas A, Patenaude A, Vallières L. Interleukin-36γ is expressed by neutrophils and can activate microglia, but has no role in experimental autoimmune encephalomyelitis. J Neuroinflammation. 2015;12:173 pubmed publisher
Doisne J, Balmas E, Boulenouar S, Gaynor L, Kieckbusch J, Gardner L, et al. Composition, Development, and Function of Uterine Innate Lymphoid Cells. J Immunol. 2015;195:3937-45 pubmed publisher
Chen M, Liang D, Zuo A, Shao H, Kaplan H, Sun D. An A2B Adenosine Receptor Agonist Promotes Th17 Autoimmune Responses in Experimental Autoimmune Uveitis (EAU) via Dendritic Cell Activation. PLoS ONE. 2015;10:e0132348 pubmed publisher
Lombes A, Durand A, Charvet C, Rivière M, Bonilla N, Auffray C, et al. Adaptive Immune-like γ/δ T Lymphocytes Share Many Common Features with Their α/β T Cell Counterparts. J Immunol. 2015;195:1449-58 pubmed publisher
Russi A, Walker Caulfield M, Ebel M, Brown M. Cutting edge: c-Kit signaling differentially regulates type 2 innate lymphoid cell accumulation and susceptibility to central nervous system demyelination in male and female SJL mice. J Immunol. 2015;194:5609-13 pubmed publisher
Klimatcheva E, Pandina T, Reilly C, Torno S, Bussler H, Scrivens M, et al. CXCL13 antibody for the treatment of autoimmune disorders. BMC Immunol. 2015;16:6 pubmed publisher
Kim Y, Lim H, Jung H, Wetsel R, Chung Y. Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells. PLoS ONE. 2015;10:e0120294 pubmed publisher
de Andrade Pereira B, Ackermann M, Chaudhary S, Vogel R, Vogt B, Dresch C, et al. Tolerance of activated pathogenic CD4+ T cells by transcriptional targeting of dendritic cells. Gene Ther. 2015;22:382-90 pubmed publisher
Okamura T, Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, et al. TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses. Nat Commun. 2015;6:6329 pubmed publisher
Muñoz M, Eidenschenk C, Ota N, Wong K, Lohmann U, Kühl A, et al. Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection. Immunity. 2015;42:321-331 pubmed publisher
Schwinge D, Carambia A, Quaas A, Krech T, Wegscheid C, Tiegs G, et al. Testosterone suppresses hepatic inflammation by the downregulation of IL-17, CXCL-9, and CXCL-10 in a mouse model of experimental acute cholangitis. J Immunol. 2015;194:2522-30 pubmed publisher
Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, et al. IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance. Nat Immunol. 2015;16:286-95 pubmed publisher
Monin L, Griffiths K, Slight S, Lin Y, Rangel Moreno J, Khader S. Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challenge. Mucosal Immunol. 2015;8:1099-109 pubmed publisher
Harada M, Kamimura D, Arima Y, Kohsaka H, Nakatsuji Y, Nishida M, et al. Temporal expression of growth factors triggered by epiregulin regulates inflammation development. J Immunol. 2015;194:1039-46 pubmed publisher
Abadier M, Haghayegh Jahromi N, Cardoso Alves L, Boscacci R, Vestweber D, Barnum S, et al. Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier. Eur J Immunol. 2015;45:1043-58 pubmed publisher
Haftmann C, Stittrich A, Zimmermann J, Fang Z, Hradilkova K, Bardua M, et al. miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim. Eur J Immunol. 2015;45:1192-205 pubmed publisher
Chen J, Waddell A, Lin Y, Cantorna M. Dysbiosis caused by vitamin D receptor deficiency confers colonization resistance to Citrobacter rodentium through modulation of innate lymphoid cells. Mucosal Immunol. 2015;8:618-26 pubmed publisher
Dunne A, Mielke L, Allen A, Sutton C, Higgs R, Cunningham C, et al. A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine. Mucosal Immunol. 2015;8:607-17 pubmed publisher
Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi M, Ahlers J, et al. Role of Blimp-1 in programing Th effector cells into IL-10 producers. J Exp Med. 2014;211:1807-19 pubmed publisher
Schiering C, Krausgruber T, Chomka A, Fröhlich A, Adelmann K, Wohlfert E, et al. The alarmin IL-33 promotes regulatory T-cell function in the intestine. Nature. 2014;513:564-568 pubmed publisher
Knowlden S, Capece T, Popovic M, Chapman T, Rezaee F, Kim M, et al. Regulation of T cell motility in vitro and in vivo by LPA and LPA2. PLoS ONE. 2014;9:e101655 pubmed publisher
Mycko M, Sliwinska B, Cichalewska M, Cwiklinska H, Raine C, Selmaj K. Brain glycolipids suppress T helper cells and inhibit autoimmune demyelination. J Neurosci. 2014;34:8646-58 pubmed publisher
Glenn J, Smith M, Calabresi P, Whartenby K. Mesenchymal stem cells differentially modulate effector CD8+ T cell subsets and exacerbate experimental autoimmune encephalomyelitis. Stem Cells. 2014;32:2744-55 pubmed publisher
Hou Y, Lin H, Zhu L, Liu Z, Hu F, Shi J, et al. The inhibitory effect of IFN-? on protease HTRA1 expression in rheumatoid arthritis. J Immunol. 2014;193:130-8 pubmed publisher
Reynolds C, Chong D, Raynsford E, Quigley K, Kelly D, Llewellyn Hughes J, et al. Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile. BMC Biol. 2014;12:32 pubmed publisher
Zhu E, Wang X, Zheng B, Wang Q, Hao J, Chen S, et al. miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting ROR?t and STAT3. J Immunol. 2014;192:5599-609 pubmed publisher
Yeste A, Mascanfroni I, Nadeau M, Burns E, Tukpah A, Santiago A, et al. IL-21 induces IL-22 production in CD4+ T cells. Nat Commun. 2014;5:3753 pubmed publisher
Sriskantharajah S, Gückel E, Tsakiri N, Kierdorf K, Brender C, Ben Addi A, et al. Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase. J Immunol. 2014;192:3518-3529 pubmed publisher
Wang Y, Godec J, Ben Aissa K, Cui K, Zhao K, Pucsek A, et al. The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cells. Immunity. 2014;40:355-66 pubmed publisher
Zhou H, Wang Y, Lian Q, Yang B, Ma Y, Wu X, et al. Differential IL-10 production by DCs determines the distinct adjuvant effects of LPS and PTX in EAE induction. Eur J Immunol. 2014;44:1352-62 pubmed publisher
Ikeda S, Saijo S, Murayama M, Shimizu K, Akitsu A, Iwakura Y. Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-?-induced Foxp3 expression. J Immunol. 2014;192:1449-58 pubmed publisher
Guo X, Qiu J, Tu T, Yang X, Deng L, Anders R, et al. Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection. Immunity. 2014;40:25-39 pubmed publisher
Yang C, Li J, Chiu L, Lan J, Chen D, Chuang H, et al. Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation. J Immunol. 2014;192:1547-57 pubmed publisher
Pierson E, Stromnes I, GOVERMAN J. B cells promote induction of experimental autoimmune encephalomyelitis by facilitating reactivation of T cells in the central nervous system. J Immunol. 2014;192:929-39 pubmed publisher
Ashino S, Takeda K, Li H, Taylor V, Joetham A, Pine P, et al. Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses. J Allergy Clin Immunol. 2014;133:1162-74 pubmed publisher
Liu Y, Holdbrooks A, De Sarno P, Rowse A, Yanagisawa L, McFarland B, et al. Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis. J Immunol. 2014;192:59-72 pubmed publisher
Fisher Y, Strominger I, Biton S, Nemirovsky A, Baron R, Monsonego A. Th1 polarization of T cells injected into the cerebrospinal fluid induces brain immunosurveillance. J Immunol. 2014;192:92-102 pubmed publisher
Chen J, Cascio J, Magee J, Techasintana P, Gubin M, Dahm G, et al. Posttranscriptional gene regulation of IL-17 by the RNA-binding protein HuR is required for initiation of experimental autoimmune encephalomyelitis. J Immunol. 2013;191:5441-50 pubmed publisher
Chen Y, Peng H, Chen Y, Wei H, Sun R, Tian Z. CD49a promotes T-cell-mediated hepatitis by driving T helper 1 cytokine and interleukin-17 production. Immunology. 2014;141:388-400 pubmed publisher
Mascanfroni I, Yeste A, Vieira S, Burns E, Patel B, Sloma I, et al. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat Immunol. 2013;14:1054-63 pubmed publisher
Ishida H, Imai T, Suzue K, Hirai M, Taniguchi T, Yoshimura A, et al. IL-23 protection against Plasmodium berghei infection in mice is partially dependent on IL-17 from macrophages. Eur J Immunol. 2013;43:2696-706 pubmed publisher
Yanaba K, Kamata M, Ishiura N, Shibata S, Asano Y, Tada Y, et al. Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation. J Leukoc Biol. 2013;94:563-73 pubmed publisher
Matsumoto A, Kanai T, Mikami Y, Chu P, Nakamoto N, Ebinuma H, et al. IL-22-producing ROR?t-dependent innate lymphoid cells play a novel protective role in murine acute hepatitis. PLoS ONE. 2013;8:e62853 pubmed publisher
Liu H, Yao S, Dann S, Qin H, Elson C, Cong Y. ERK differentially regulates Th17- and Treg-cell development and contributes to the pathogenesis of colitis. Eur J Immunol. 2013;43:1716-26 pubmed publisher
Simons D, Oh S, Kropf E, Aitken M, Garcia V, Basehoar A, et al. Autoreactive Th1 cells activate monocytes to support regional Th17 responses in inflammatory arthritis. J Immunol. 2013;190:3134-41 pubmed publisher
Flanagan K, FITZGERALD K, Baker J, Regnstrom K, Gardai S, Bard F, et al. Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS. PLoS ONE. 2012;7:e40443 pubmed publisher
Freeman B, Hammarlund E, Raué H, Slifka M. Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A. 2012;109:9971-6 pubmed publisher
Casey K, Fraser K, Schenkel J, Moran A, Abt M, Beura L, et al. Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues. J Immunol. 2012;188:4866-75 pubmed publisher
Alcaide P, Maganto Garcia E, Newton G, Travers R, CROCE K, Bu D, et al. Difference in Th1 and Th17 lymphocyte adhesion to endothelium. J Immunol. 2012;188:1421-30 pubmed publisher
Gessner M, Werner J, Lilly L, Nelson M, Metz A, Dunaway C, et al. Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus. Infect Immun. 2012;80:410-7 pubmed publisher
Dubin P, Martz A, Eisenstatt J, Fox M, Logar A, Kolls J. Interleukin-23-mediated inflammation in Pseudomonas aeruginosa pulmonary infection. Infect Immun. 2012;80:398-409 pubmed publisher
Monticelli L, Sonnenberg G, Abt M, Alenghat T, Ziegler C, Doering T, et al. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat Immunol. 2011;12:1045-54 pubmed publisher
Fridman J, Scherle P, Collins R, Burn T, Neilan C, Hertel D, et al. Preclinical evaluation of local JAK1 and JAK2 inhibition in cutaneous inflammation. J Invest Dermatol. 2011;131:1838-44 pubmed publisher
Breslow J, Meissler J, Hartzell R, Spence P, Truant A, Gaughan J, et al. Innate immune responses to systemic Acinetobacter baumannii infection in mice: neutrophils, but not interleukin-17, mediate host resistance. Infect Immun. 2011;79:3317-27 pubmed publisher
Ma Y, Aymeric L, Locher C, Mattarollo S, Delahaye N, Pereira P, et al. Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. J Exp Med. 2011;208:491-503 pubmed publisher
Nakajima K, Kanda T, Takaishi M, Shiga T, Miyoshi K, Nakajima H, et al. Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model. J Immunol. 2011;186:4481-9 pubmed publisher
Sawa S, Lochner M, Satoh Takayama N, Dulauroy S, Berard M, Kleinschek M, et al. ROR?t+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota. Nat Immunol. 2011;12:320-6 pubmed publisher
Depaolo R, Abadie V, Tang F, Fehlner Peach H, Hall J, Wang W, et al. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature. 2011;471:220-4 pubmed publisher
Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, et al. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J Virol. 2010;84:12703-12 pubmed publisher
Jones G, Stumhofer J, Foster T, Twohig J, Hertzog P, Topley N, et al. Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. FASEB J. 2011;25:409-19 pubmed publisher
De Luca A, Zelante T, D Angelo C, Zagarella S, Fallarino F, Spreca A, et al. IL-22 defines a novel immune pathway of antifungal resistance. Mucosal Immunol. 2010;3:361-73 pubmed publisher
Cho J, Pietras E, Garcia N, Ramos R, Farzam D, Monroe H, et al. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest. 2010;120:1762-73 pubmed publisher
Meeks K, Sieve A, Kolls J, Ghilardi N, Berg R. IL-23 is required for protection against systemic infection with Listeria monocytogenes. J Immunol. 2009;183:8026-34 pubmed publisher
Lemos H, Grespan R, Vieira S, Cunha T, Verri W, Fernandes K, et al. Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Proc Natl Acad Sci U S A. 2009;106:5954-9 pubmed publisher
Hamada H, Garcia Hernandez M, Reome J, Misra S, Strutt T, McKinstry K, et al. Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. J Immunol. 2009;182:3469-81 pubmed publisher
McKinley L, Alcorn J, Peterson A, Dupont R, Kapadia S, Logar A, et al. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J Immunol. 2008;181:4089-97 pubmed
Shinohara M, Kim J, Garcia V, Cantor H. Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. Immunity. 2008;29:68-78 pubmed publisher
Guo B, Chang E, Cheng G. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J Clin Invest. 2008;118:1680-90 pubmed publisher
Smith E, Zarbock A, Stark M, Burcin T, Bruce A, Foley P, et al. IL-23 is required for neutrophil homeostasis in normal and neutrophilic mice. J Immunol. 2007;179:8274-9 pubmed
Fitzgerald D, Zhang G, El Behi M, Fonseca Kelly Z, Li H, Yu S, et al. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat Immunol. 2007;8:1372-9 pubmed
Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, et al. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur J Immunol. 2007;37:2695-706 pubmed
Brüstle A, Heink S, Huber M, Rosenplänter C, Stadelmann C, Yu P, et al. The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat Immunol. 2007;8:958-66 pubmed
Nakano N, Nishiyama C, Kanada S, Niwa Y, Shimokawa N, Ushio H, et al. Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections. Blood. 2007;109:4846-55 pubmed
Ivanov S, Bozinovski S, Bossios A, Valadi H, Vlahos R, Malmhäll C, et al. Functional relevance of the IL-23-IL-17 axis in lungs in vivo. Am J Respir Cell Mol Biol. 2007;36:442-51 pubmed
Bettelli E, Carrier Y, Gao W, Korn T, Strom T, Oukka M, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441:235-8 pubmed
Harrington L, Hatton R, Mangan P, Turner H, Murphy T, Murphy K, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005;6:1123-32 pubmed
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
1887-ML/CF
SKU :
1887-ML-010/CF
product name :
Recombinant Mouse IL-23 Protein, CF
Description :
The Recombinant Mouse IL-23 Protein, CF from R&D Systems is derived from Sf 21 (stably transfected). The Recombinant Mouse IL-23 Protein, CF has been validated for the following applications: Bioactivity.
target :
IL-23
category :
Proteins and Enzymes
unit size :
10 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Mouse
observed molecular weight :
(58-71) kDa, non-reducing conditions
theoretical molecular weight :
57 kDa
gene symbol :
Il23a
details of functionality :
Measured by its ability to induce IL-17 secretion by mouse splenocytes. Aggarwal, S. et al . (2003) J. Biol. Chem. 278 :1910. The ED50 for this effect is 0.05-0.25 ng/mL.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P43432 (p40) Q9EQ14 (p19)
applications :
Bioactivity
source :
Sf 21 (stably transfected)-derived Recombinant Mouse IL-23 Protein
USD :
435 USD
alt names :
IL23, IL-23, IL-23 p19/IL-12 p40, IL-23A, IL-23-A, IL-23p19, IL-23p19/IL-12p40, IL23P19P19, interleukin 23 p19 subunit, interleukin 23, alpha subunit p19, interleukin-23 subunit alpha, Interleukin-23 subunit p19, JKA3 induced upon T-cell activation, MGC79388, SGRF, SGRFIL-23 subunit alpha
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.