This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Fc gamma RIIB/C (CD32b/c) Protein, CF
catalog :
1875-CD
quantity :
50 ug
price :
349 USD
citations: 10
Reference
Blundell P, Lu D, Wilkinson M, Dell A, Haslam S, Pleass R. Insertion of N-Terminal Hinge Glycosylation Enhances Interactions of the Fc Region of Human IgG1 Monomers with Glycan-Dependent Receptors and Blocks Hemagglutination by the Influenza Virus. J Immunol. 2019;202:1595-1611 pubmed publisher
Arce Vargas F, Furness A, Litchfield K, Joshi K, Rosenthal R, Ghorani E, et al. Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies. Cancer Cell. 2018;33:649-663.e4 pubmed publisher
Seo N, Polozova A, Zhang M, Yates Z, Cao S, Li H, et al. Analytical and functional similarity of Amgen biosimilar ABP 215 to bevacizumab. MAbs. 2018;10:678-691 pubmed publisher
Zhang D, Whitaker B, DEREBE M, Chiu M. Fc?RII-binding Centyrins mediate agonism and antibody-dependent cellular phagocytosis when fused to an anti-OX40 antibody. MAbs. 2018;: pubmed publisher
Järnum S, Runström A, Bockermann R, Winstedt L, Crispin M, Kjellman C. Enzymatic Inactivation of Endogenous IgG by IdeS Enhances Therapeutic Antibody Efficacy. Mol Cancer Ther. 2017;16:1887-1897 pubmed publisher
Meuris L, Santens F, Elson G, Festjens N, Boone M, Dos Santos A, et al. GlycoDelete engineering of mammalian cells simplifies N-glycosylation of recombinant proteins. Nat Biotechnol. 2014;32:485-9 pubmed publisher
Xie J, Yamniuk A, Borowski V, Kuhn R, Susulic V, Rex Rabe S, et al. Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases. J Immunol. 2014;192:4083-92 pubmed publisher
Derer S, Glorius P, Schlaeth M, Lohse S, Klausz K, Muchhal U, et al. Increasing Fc?RIIa affinity of an Fc?RIII-optimized anti-EGFR antibody restores neutrophil-mediated cytotoxicity. MAbs. 2014;6:409-21 pubmed publisher
Williams E, Tutt A, French R, Chan H, Lau B, Penfold C, et al. Development and characterisation of monoclonal antibodies specific for the murine inhibitory Fc?RIIB (CD32B). Eur J Immunol. 2012;42:2109-20 pubmed publisher
Richards J, Karki S, Lazar G, Chen H, Dang W, Desjarlais J. Optimization of antibody binding to FcgammaRIIa enhances macrophage phagocytosis of tumor cells. Mol Cancer Ther. 2008;7:2517-27 pubmed publisher
product information
brand :
R&D Systems
master code :
1875-CD
SKU :
1875-CD-050
product name :
Recombinant Human Fc gamma RIIB/C (CD32b/c) Protein, CF
description :
The Recombinant Human Fc gamma RIIB/C (CD32b/c) Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Fc gamma RIIB/C (CD32b/c) Protein, CF has been validated for the following applications: Binding Activity.
target :
Fc gamma RIIB/C (CD32b/c)
category :
Proteins and Enzymes
unit size :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
25-35 kDa, reducing conditions
theoretical molecular weight :
21 kDa
gene symbol :
FCGR2B
details of functionality :
Measured by its ability to bind human IgG with an estimated Kd 200 nM.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
catalog number base :
1875-CD
accessionNumbers :
P31994
applications :
Binding Activity
source :
Mouse myeloma cell line, NS0-derived human Fc gamma RIIB/C (CD32b/c) protein Ala46-Pro217, with a C-terminal 10-His tag
2020 USD :
349
2021 USD :
349 USD
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.