Recombinant Human IL-26/AK155 Dimer Protein | R&D Systems 1870-IL-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-26/AK155 Dimer Protein

catalog :

1870-IL-010

quantity :

10 ug (also 500 ug)

price :

544 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Itoh T, Hatano R, Horimoto Y, Yamada T, Song D, Otsuka H, et al. IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells. Cell Death Dis. 2021;12:520 pubmed publisher
Trotter T, Shuptrine C, Tsao L, Marek R, Acharya C, Wei J, et al. IL26, a Noncanonical Mediator of DNA Inflammatory Stimulation, Promotes TNBC Engraftment and Progression in Association with Neutrophils. Cancer Res. 2020;80:3088-3100 pubmed publisher
Bao A, Che K, Bozinovski S, Ji J, Gregory J, Kumlien Georén S, et al. Recombinant human IL-26 facilitates the innate immune response to endotoxin in the bronchoalveolar space of mice in vivo. PLoS ONE. 2017;12:e0188909 pubmed publisher
Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, et al. IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. PLoS Biol. 2012;10:e1001395 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Sheikh F, Baurin V, Lewis Antes A, Shah N, Smirnov S, Anantha S, et al. Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. J Immunol. 2004;172:2006-10 pubmed

product information

brand :

R&D Systems

master code :

1870-IL

SKU :

1870-IL-010

product name :

Recombinant Human IL-26/AK155 Dimer Protein

unit size :

10 ug (also 500 ug)

seo description :

The Recombinant Human IL-26/AK155 Dimer Protein from R&D Systems is derived from E. coli. The Recombinant Human IL-26/AK155 Dimer Protein has been validated for the following applications: Bioactivity.

target :

IL-26/AK155

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in NaH2PO4, NaCl and Glycerol with BSA as a carrier protein.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

18 kDa, reducing conditions 36 kDa, non-reducing conditions

theoretical molecular weight :

17.7 kDa (monomer)

gene symbol :

IL26

details of functionality :

Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells. Hor, S. et al . (2004) J. Biol. Chem. 279 :33343. The ED50 for this effect is 10-75 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q9NPH9.1

applications :

Bioactivity

source :

E. coli-derived Recombinant Human IL-26/AK155 Dimer Protein

USD :

544 USD

alt names :

AK155, AK155IL-26interleukin-26, IL26, interleukin 26, Protein AK155

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after opening.

more info or order :

R&D Systems product webpage