Recombinant Human Dectin-1/CLEC7A Protein, CF | R&D Systems 1859-DC-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Dectin-1/CLEC7A Protein, CF

catalog :

1859-DC-050

quantity :

50 ug

price :

456 USD

more info or order :

R&D Systems product webpage

citations: 9

Reference
Michaud E, Waeckel L, Gayet R, Goguyer Deschaumes R, Chanut B, Jospin F, et al. Alteration of microbiota antibody-mediated immune selection contributes to dysbiosis in inflammatory bowel diseases. EMBO Mol Med. 2022;14:e15386 pubmed publisher
Yamanaka D, Suzuki K, Kimura M, Oyama F, Adachi Y. Functionally modified chitotriosidase catalytic domain for chitin detection based on split-luciferase complementation. Carbohydr Polym. 2022;282:119125 pubmed publisher
He X, Howard B, Liu Y, Neumann A, Li L, Menon N, et al. LYSMD3: A mammalian pattern recognition receptor for chitin. Cell Rep. 2021;36:109392 pubmed publisher
Leclaire C, Lecointe K, Gunning P, Tribolo S, Kavanaugh D, Wittmann A, et al. Molecular basis for intestinal mucin recognition by galectin-3 and C-type lectins. FASEB J. 2018;32:3301-3320 pubmed publisher
Griffiths J, Thompson A, Stott M, Benny A, Lewis N, Taylor P, et al. Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases. FASEB J. 2018;32:3385-3397 pubmed publisher
Smith A, Graves B, Child R, Rice P, Ma Z, Lowman D, et al. Immunoregulatory Activity of the Natural Product Laminarin Varies Widely as a Result of Its Physical Properties. J Immunol. 2018;200:788-799 pubmed publisher
Bene K, Kavanaugh D, Leclaire C, Gunning A, MacKenzie D, Wittmann A, et al. Lactobacillus reuteri Surface Mucus Adhesins Upregulate Inflammatory Responses Through Interactions With Innate C-Type Lectin Receptors. Front Microbiol. 2017;8:321 pubmed publisher
Kerr S, Fischer G, Sinha M, McCabe O, Palmer J, Choera T, et al. FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection. PLoS Pathog. 2016;12:e1005555 pubmed publisher
. Correction: A chitin-like component on sclerotic cells of fonsecaea pedrosoi inhibits dectin-1-mediated murine Th17 development by masking ?-glucans. PLoS ONE. 2015;10:e0119244 pubmed publisher

product information

brand :

R&D Systems

master code :

1859-DC

SKU :

1859-DC-050

product name :

Recombinant Human Dectin-1/CLEC7A Protein, CF

unit size :

50 ug

seo description :

The Recombinant Human Dectin-1/CLEC7A Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Dectin-1/CLEC7A Protein, CF has been validated for the following applications: Binding Activity.

target :

Dectin-1/CLEC7A

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Binding Activity

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

theoretical molecular weight :

16.8 kDa

gene symbol :

CLEC7A

details of functionality :

Measured by its ability to bind biotinylated Laminarin (1, 3┐▀-glucan) in a functional ELISA with an estimated KD 5 nM.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

NP_072092

applications :

Binding Activity

source :

NS0-derived Recombinant Human Dectin-1/CLEC7A Protein, CF

USD :

456 USD

alt names :

Beta-glucan receptor, BGR, CD369, CLEC7A, CLECSF12, CLECSF12DC-associated C-type lectin 1, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamilymember 12, C-type lectin domain family 7 member A, C-type lectin domain family 7, member A, C-type lectin superfamily member 12, dectin-1, Dectin1, DECTIN1CANDF4, Dendritic cell-associated C-type lectin 1, dendritic cell-associated C-type lectin-1, hDectin-1, lectin-like receptor 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage