product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse Lipocalin-2/NGAL Protein, CF
catalog :
1857-LC-050
quantity :
50 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 25
Reference
Zhuang X, Wang Q, Joost S, Ferrena A, Humphreys D, Li Z, et al. Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis. bioRxiv. 2024;: pubmed publisher
Su H, Guo H, Qiu X, Lin T, Qin C, Celio G, et al. Lipocalin 2 regulates mitochondrial phospholipidome remodeling, dynamics, and function in brown adipose tissue in male mice. Nat Commun. 2023;14:6729 pubmed publisher
Liu Y, Smith M, Wang Y, D AGOSTINO R, Ruiz J, Lycan T, et al. c-Met Mediated Cytokine Network Promotes Brain Metastasis of Breast Cancer by Remodeling Neutrophil Activities. Cancers (Basel). 2023;15: pubmed publisher
Sheldon J, Himmel L, Kunkle D, Monteith A, Maloney K, Skaar E. Lipocalin-2 is an essential component of the innate immune response to Acinetobacter baumannii infection. PLoS Pathog. 2022;18:e1010809 pubmed publisher
Xiang X, Tang X, Yu Y, Xie S, Liu L, Chen M, et al. Role of lipocalin-2 in surgery-induced cognitive decline in mice: a signal from neuron to microglia. J Neuroinflammation. 2022;19:92 pubmed publisher
Huisman C, Norgard M, Levasseur P, Krasnow S, van der Wijst M, Olson B, et al. Critical changes in hypothalamic gene networks in response to pancreatic cancer as found by single-cell RNA sequencing. Mol Metab. 2022;58:101441 pubmed publisher
Wang X, Li X, Zuo X, Liang Z, Ding T, Li K, et al. Photobiomodulation inhibits the activation of neurotoxic microglia and astrocytes by inhibiting Lcn2/JAK2-STAT3 crosstalk after spinal cord injury in male rats. J Neuroinflammation. 2021;18:256 pubmed publisher
Chen Y, Xie S, Chen C, Lu D. Electroacupuncture improves repeated social defeat stress-elicited social avoidance and anxiety-like behaviors by reducing Lipocalin-2 in the hippocampus. Mol Brain. 2021;14:150 pubmed publisher
Olson B, Zhu X, Norgard M, Diba P, Levasseur P, Buenafe A, et al. Chronic cerebral lipocalin 2 exposure elicits hippocampal neuronal dysfunction and cognitive impairment. Brain Behav Immun. 2021;97:102-118 pubmed publisher
Olson B, Zhu X, Norgard M, Levasseur P, Butler J, BUENAFE A, et al. Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia. Nat Commun. 2021;12:2057 pubmed publisher
Yan J, Pandey S, Barnes B, Turner J, Abraham C. T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation. Cell Rep. 2020;31:107820 pubmed publisher
Yammine L, Zablocki A, BARON W, Terzi F, Gallazzini M. Lipocalin-2 Regulates Epidermal Growth Factor Receptor Intracellular Trafficking. Cell Rep. 2019;29:2067-2077.e6 pubmed publisher
Ondee T, Gillen J, Visitchanakun P, Somparn P, Issara Amphorn J, Dang Phi C, et al. Lipocalin-2 (Lcn-2) Attenuates Polymicrobial Sepsis with LPS Preconditioning (LPS Tolerance) in FcGRIIb Deficient Lupus Mice. Cells. 2019;8: pubmed publisher
Ishii A, Katsuura G, Imamaki H, Kimura H, Mori K, Kuwabara T, et al. Obesity-promoting and anti-thermogenic effects of neutrophil gelatinase-associated lipocalin in mice. Sci Rep. 2017;7:15501 pubmed publisher
Garbacz W, Jiang M, Xu M, Yamauchi J, Dong H, Xie W. Sex- and Tissue-Specific Role of Estrogen Sulfotransferase in Energy Homeostasis and Insulin Sensitivity. Endocrinology. 2017;158:4093-4104 pubmed publisher
Ferreira A, Santos T, Sampaio Marques B, Novais A, Mesquita S, Ludovico P, et al. Lipocalin-2 regulates adult neurogenesis and contextual discriminative behaviours. Mol Psychiatry. 2018;23:1031-1039 pubmed publisher
Villalvilla A, Garcia Martin A, Largo R, Gualillo O, Herrero Beaumont G, Gomez R. The adipokine lipocalin-2 in the context of the osteoarthritic osteochondral junction. Sci Rep. 2016;6:29243 pubmed publisher
Rucci N, Capulli M, Piperni S, Cappariello A, Lau P, Frings Meuthen P, et al. Lipocalin 2: a new mechanoresponding gene regulating bone homeostasis. J Bone Miner Res. 2015;30:357-68 pubmed publisher
Maung R, Hoefer M, Sanchez A, Sejbuk N, Medders K, Desai M, et al. CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120. J Immunol. 2014;193:1895-910 pubmed publisher
Floderer M, Prchal Murphy M, Vizzardelli C. Dendritic cell-secreted lipocalin2 induces CD8+ T-cell apoptosis, contributes to T-cell priming and leads to a TH1 phenotype. PLoS ONE. 2014;9:e101881 pubmed publisher
Miao Q, Ku A, Nishino Y, Howard J, Rao A, Shaver T, et al. Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2. Nat Commun. 2014;5:4088 pubmed publisher
Jeon S, Jha M, Ock J, Seo J, Jin M, Cho H, et al. Role of lipocalin-2-chemokine axis in the development of neuropathic pain following peripheral nerve injury. J Biol Chem. 2013;288:24116-27 pubmed publisher
Shashidharamurthy R, Machiah D, Aitken J, Putty K, Srinivasan G, Chassaing B, et al. Differential role of lipocalin 2 during immune complex-mediated acute and chronic inflammation in mice. Arthritis Rheum. 2013;65:1064-73 pubmed publisher
Nairz M, Theurl I, Schroll A, Theurl M, Fritsche G, Lindner E, et al. Absence of functional Hfe protects mice from invasive Salmonella enterica serovar Typhimurium infection via induction of lipocalin-2. Blood. 2009;114:3642-51 pubmed publisher
Zhang J, Wu Y, Zhang Y, LeRoith D, Bernlohr D, Chen X. The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages. Mol Endocrinol. 2008;22:1416-26 pubmed publisher
product information
brand :
R&D Systems
master code :
1857-LC
SKU :
1857-LC-050
product name :
Recombinant Mouse Lipocalin-2/NGAL Protein, CF
unit size :
50 ug
seo description :
The Recombinant Mouse Lipocalin-2/NGAL Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse Lipocalin-2/NGAL Protein, CF has been validated for the following applications: Binding Activity.
target :
Lipocalin-2/NGAL
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 ╡m filtered solution in MES and NaCl.
conjugate :
Unconjugated
dilution :
Binding Activity
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Mouse
observed molecular weight :
26-27 kDa doublet, reducing conditions
theoretical molecular weight :
22 kDa
gene symbol :
Lcn2
details of functionality :
Measured by its ability to bind Iron(III) dihydroxybenzoic acid [Fe(DHBA)3]. The binding of Fe(DHBA)3 results in the quenching of Trp fluorescence in Lipocalin-2. 1.0 ╡M of Fe(DHBA)3 can be bound under the described conditions.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
P11672
applications :
Binding Activity
source :
NS0-derived Recombinant Mouse Lipocalin-2/NGAL Protein, CF
USD :
432 USD
alt names :
24p3, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, HNL, LCN2, lipocalin 2, lipocalin 2 (oncogene 24p3), Lipocalin2, Lipocalin-2, migration-stimulating factor inhibitor, MSFI, neutrophil gelatinase-associated lipocalin, NGAL, NGALlipocalin-2, Oncogene 24p3, p25, Siderocalin, Uterocalin
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.