product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human NKp46/NCR1 Fc Chimera Protein, CF
catalog :
1850-NK-025
quantity :
25 ug
price :
443 USD
more info or order :
R&D Systems product webpage
citations: 16
Reference
Sen Santara S, Lee D, Crespo x, Hu J, Walker C, Ma X, et al. The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells. Nature. 2023;616:348-356 pubmed publisher
Murayama Y, Kasahara Y, Kubo N, Shin C, Imamura M, Oike N, et al. NKp44-based chimeric antigen receptor effectively redirects primary T cells against synovial sarcoma. Transl Oncol. 2022;25:101521 pubmed publisher
Tremblay McLean A, Coenraads S, Kiani Z, Dupuy F, Bernard N. Expression of ligands for activating natural killer cell receptors on cell lines commonly used to assess natural killer cell function. BMC Immunol. 2019;20:8 pubmed publisher
Yoshioka T, Tatsumi T, Miyagi T, Mukai K, Nishio K, Nishio A, et al. Frequency and role of NKp46 and NKG2A in hepatitis B virus infection. PLoS ONE. 2017;12:e0174103 pubmed publisher
Gross C, Schulte Mecklenbeck A, Rünzi A, Kuhlmann T, Posevitz Fejfár A, Schwab N, et al. Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation. Proc Natl Acad Sci U S A. 2016;113:E2973-82 pubmed publisher
Forslund E, Sohlberg E, Enqvist M, Olofsson P, Malmberg K, Önfelt B. Microchip-Based Single-Cell Imaging Reveals That CD56dimCD57-KIR-NKG2A+ NK Cells Have More Dynamic Migration Associated with Increased Target Cell Conjugation and Probability of Killing Compared to CD56dimCD57-KIR-NKG2A- NK Cells. J Immunol. 2015;195:3374-81 pubmed publisher
Kruse V, Hamann C, Monecke S, Cyganek L, Elsner L, Hübscher D, et al. Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1. PLoS ONE. 2015;10:e0125544 pubmed publisher
Robinet P, Baychelier F, Fontaine T, Picard C, Debre P, Vieillard V, et al. A polysaccharide virulence factor of a human fungal pathogen induces neutrophil apoptosis via NK cells. J Immunol. 2014;192:5332-42 pubmed publisher
Siewiera J, El Costa H, Tabiasco J, Berrebi A, Cartron G, Le Bouteiller P, et al. Human cytomegalovirus infection elicits new decidual natural killer cell effector functions. PLoS Pathog. 2013;9:e1003257 pubmed publisher
Reiners K, Kessler J, Sauer M, Rothe A, Hansen H, Reusch U, et al. Rescue of impaired NK cell activity in hodgkin lymphoma with bispecific antibodies in vitro and in patients. Mol Ther. 2013;21:895-903 pubmed publisher
Bellucci R, Nguyen H, Martin A, Heinrichs S, Schinzel A, Hahn W, et al. Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells. J Clin Invest. 2012;122:2369-83 pubmed publisher
Dupuy S, Lambert M, Zucman D, Choukem S, Tognarelli S, Pagès C, et al. Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma. PLoS Pathog. 2012;8:e1002486 pubmed publisher
Esin S, Batoni G, Counoupas C, Stringaro A, Brancatisano F, Colone M, et al. Direct binding of human NK cell natural cytotoxicity receptor NKp44 to the surfaces of mycobacteria and other bacteria. Infect Immun. 2008;76:1719-27 pubmed publisher
Shi J, Tricot G, Garg T, Malaviarachchi P, Szmania S, Kellum R, et al. Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma. Blood. 2008;111:1309-17 pubmed
Banerjee P, Feuer G, Barker E. Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the. J Virol. 2007;81:9707-17 pubmed
Ward J, Bonaparte M, Sacks J, Guterman J, Fogli M, Mavilio D, et al. HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts. Blood. 2007;110:1207-14 pubmed
product information
master code :
1850-NK
SKU :
1850-NK-025
product name :
Recombinant Human NKp46/NCR1 Fc Chimera Protein, CF
unit size :
25 ug
description :
The Recombinant Human NKp46/NCR1 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human NKp46/NCR1 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
NKp46/NCR1
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
60-80 kDa, reducing conditions
theoretical molecular weight :
53 kDa (monomer)
gene symbol :
NCR1
details of functionality :
Measured by its ability to bind Recombinant Human Vimentin (Catalog # 2105-VI ) in a functional ELISA with an estimated KD 2 nM. Garg, A. et al . (2006) J. Immunol. 177 :6192.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
AAH64806
applications :
Bioactivity
source long :
Mouse myeloma cell line, NS0-derived human NKp46/NCR1 protein Human NKp46 (Gln22 - Asn254) Accession #AAH64806 IEGRMD Human IgG1 (Pro100 - Lys330) N-terminus C-terminus
source short :
NS0
USD :
443 USD
alt names :
CD335, CD335 antigen, hNKp46, Ly94, LY94lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46), Lymphocyte antigen 94 homolog, MAR-1, natural cytotoxicity triggering receptor 1, Natural killer cell p46-related protein, NCR1, NK cell-activating receptor, NKp46, NKP46FLJ99094, NK-p46lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46)
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.