Recombinant Human Osteoprotegerin/TNFRSF11B Protein | R&D Systems 185-OS-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Osteoprotegerin/TNFRSF11B Protein

catalog :

185-OS-025

quantity :

25 ug

price :

436 USD

more info or order :

R&D Systems product webpage

citations: 12

Reference
Vorkapic E, Kunath A, Wågsäter D. Effects of osteoprotegerin/TNFRSF11B in two models of abdominal aortic aneurysms. Mol Med Rep. 2018;18:41-48 pubmed publisher
Williams C, Qazi U, Bernstein M, Charniak A, Gohr C, Mitton Fitzgerald E, et al. Mutations in osteoprotegerin account for the CCAL1 locus in calcium pyrophosphate deposition disease. Osteoarthritis Cartilage. 2018;26:797-806 pubmed publisher
Diedisheim M, Oshima M, Albagli O, Huldt C, Ahlstedt I, Clausen M, et al. Modeling human pancreatic beta cell dedifferentiation. Mol Metab. 2018;10:74-86 pubmed publisher
Lane D, Matte I, Laplante C, Garde Granger P, Rancourt C, Piche A. Osteoprotegerin (OPG) activates integrin, focal adhesion kinase (FAK), and Akt signaling in ovarian cancer cells to attenuate TRAIL-induced apoptosis. J Ovarian Res. 2013;6:82 pubmed publisher
Feng Z, He Z, Zhang B, Chen Z. Osteoprotegerin promotes the proliferation of chondrocytes and affects the expression of ADAMTS-5 and TIMP-4 through MEK/ERK signaling. Mol Med Rep. 2013;8:1669-79 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Mabilleau G, Sabokbar A. Interleukin-32 promotes osteoclast differentiation but not osteoclast activation. PLoS ONE. 2009;4:e4173 pubmed publisher
Chamoux E, Houde N, L Ériger K, Roux S. Osteoprotegerin decreases human osteoclast apoptosis by inhibiting the TRAIL pathway. J Cell Physiol. 2008;216:536-42 pubmed publisher
Locklin R, Federici E, Espina B, Hulley P, Russell R, Edwards C. Selective targeting of death receptor 5 circumvents resistance of MG-63 osteosarcoma cells to TRAIL-induced apoptosis. Mol Cancer Ther. 2007;6:3219-28 pubmed
Secchiero P, Corallini F, Rimondi E, Chiaruttini C, di Iasio M, Rustighi A, et al. Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells. Blood. 2008;111:1287-94 pubmed
Bogatkevich G, Ludwicka Bradley A, Highland K, Hant F, Nietert P, Singleton C, et al. Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis. Arthritis Rheum. 2007;56:2432-42 pubmed
Tang C, Hsu T, Lin W, Lai M, Yang R, Hsieh S, et al. Attenuation of bone mass and increase of osteoclast formation in decoy receptor 3 transgenic mice. J Biol Chem. 2007;282:2346-54 pubmed

product information

brand :

R&D Systems

master code :

185-OS

SKU :

185-OS-025

product name :

Recombinant Human Osteoprotegerin/TNFRSF11B Protein

unit size :

25 ug

seo description :

The Recombinant Human Osteoprotegerin/TNFRSF11B Protein from R&D Systems is derived from NS0. The Recombinant Human Osteoprotegerin/TNFRSF11B Protein has been validated for the following applications: Bioactivity.

target :

Osteoprotegerin/TNFRSF11B

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

55 kDa, reducing conditions

theoretical molecular weight :

43.5 kDa (monomer)

gene symbol :

TNFRSF11B

details of functionality :

Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L-929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is 8-24 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAB53709.1

applications :

Bioactivity

source :

NS0-derived Recombinant Human Osteoprotegerin/TNFRSF11B Protein

USD :

436 USD

alt names :

OCIF, OCIFMGC29565, OPG, OPGtumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis inhibitory factor, Osteoprotegerin, TNFRSF11B, TR1, tumor necrosis factor receptor superfamily, member 11b

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage