product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IL-6R alpha (aa 20-357) Protein
catalog :
1830-SR-025
quantity :
25 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 13
Reference
Selle J, Dinger K, Jentgen V, Zanetti D, Will J, Georgomanolis T, et al. Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life. Nat Commun. 2022;13:4352 pubmed publisher
Xie H, Heier C, Meng X, Bakiri L, Pototschnig I, Tang Z, et al. An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia. Proc Natl Acad Sci U S A. 2022;119: pubmed publisher
Yuan H, Cao W, Wang T, Chen W, Yu H, Fu Y, et al. Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activation. Theranostics. 2019;9:3980-3991 pubmed publisher
Foreman H, Armstrong J, Santana A, Krug L, Reich N. The replication and transcription activator of murine gammaherpesvirus 68 cooperatively enhances cytokine-activated, STAT3-mediated gene expression. J Biol Chem. 2017;292:16257-16266 pubmed publisher
Xu E, Pereira M, Karakasilioti I, Theurich S, Al Maarri M, Rappl G, et al. Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance. Nat Commun. 2017;8:14803 pubmed publisher
Shukla S, Langley M, Singh J, Edgar J, Mohtashami M, Zuniga Pflucker J, et al. Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1. Nat Methods. 2017;14:531-538 pubmed publisher
Mancini S, White A, Bijland S, Rutherford C, Graham D, Richter E, et al. Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation. Mol Cell Endocrinol. 2017;440:44-56 pubmed publisher
Harada M, Kamimura D, Arima Y, Kohsaka H, Nakatsuji Y, Nishida M, et al. Temporal expression of growth factors triggered by epiregulin regulates inflammation development. J Immunol. 2015;194:1039-46 pubmed publisher
Cho S, Pirih F, Koh A, Michalski M, Eber M, Ritchie K, et al. The soluble interleukin-6 receptor is a mediator of hematopoietic and skeletal actions of parathyroid hormone. J Biol Chem. 2013;288:6814-25 pubmed publisher
Wunderlich C, Delic D, Behnke K, Meryk A, Ströhle P, Chaurasia B, et al. Cutting edge: Inhibition of IL-6 trans-signaling protects from malaria-induced lethality in mice. J Immunol. 2012;188:4141-4 pubmed publisher
Roy M, Richard J, Dumas A, Vallières L. CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis. J Neuroinflammation. 2012;9:18 pubmed publisher
Lee S, Lee Y, Han H. Effect of arachidonic acid on hypoxia-induced IL-6 production in mouse ES cells: Involvement of MAPKs, NF-kappaB, and HIF-1alpha. J Cell Physiol. 2010;222:574-85 pubmed publisher
Osuchowski M, Siddiqui J, Copeland S, Remick D. Sequential ELISA to profile multiple cytokines from small volumes. J Immunol Methods. 2005;302:172-81 pubmed
product information
master code :
1830-SR
SKU :
1830-SR-025
product name :
Recombinant Mouse IL-6R alpha (aa 20-357) Protein
unit size :
25 ug
description :
The Recombinant Mouse IL-6R alpha (aa 20-357) Protein from R&D Systems is derived from NS0. The Recombinant Mouse IL-6R alpha (aa 20-357) Protein has been validated for the following applications: Binding Activity.
target :
IL-6R alpha
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Mouse
observed molecular weight :
60-66 kDa, reducing conditions
theoretical molecular weight :
39 kDa (monomer)
gene symbol :
Il6ra
details of functionality :
Measured by its binding ability in a functional ELISA. When Recombinant Mouse IL-6 Protein (Catalog # 406-ML ) is immobilized at 2.00 ╡g/mL, 100 ╡L/well, Recombinant Mouse IL-6R alpha Protein (Catalog # 1830-SR) binds with an ED50 of 30.0-300 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
P22272
applications :
Binding Activity
source long :
Mouse myeloma cell line, NS0-derived mouse IL-6R alpha protein Leu20-Glu357, with a C-terminal 10-His tag
source short :
NS0
USD :
432 USD
alt names :
CD126, gp80, IL-6 R alpha, IL6Q, IL6R, IL6R alpha, IL-6R-1, IL6RA, IL-6RA, IL6RQ, interleukin 6 receptor
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.