Recombinant Mouse IL-6R alpha (aa 20-357) Protein, CF | R&D Systems 1830-SR-025/CF product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse IL-6R alpha (aa 20-357) Protein, CF

catalog :

1830-SR-025/CF

quantity :

25 ug

price :

432 USD

citations: 13

Reference
Selle J, Dinger K, Jentgen V, Zanetti D, Will J, Georgomanolis T, et al. Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life. Nat Commun. 2022;13:4352 pubmed publisher
Xie H, Heier C, Meng X, Bakiri L, Pototschnig I, Tang Z, et al. An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia. Proc Natl Acad Sci U S A. 2022;119: pubmed publisher
Yuan H, Cao W, Wang T, Chen W, Yu H, Fu Y, et al. Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activation. Theranostics. 2019;9:3980-3991 pubmed publisher
Foreman H, Armstrong J, Santana A, Krug L, Reich N. The replication and transcription activator of murine gammaherpesvirus 68 cooperatively enhances cytokine-activated, STAT3-mediated gene expression. J Biol Chem. 2017;292:16257-16266 pubmed publisher
Xu E, Pereira M, Karakasilioti I, Theurich S, Al Maarri M, Rappl G, et al. Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance. Nat Commun. 2017;8:14803 pubmed publisher
Shukla S, Langley M, Singh J, Edgar J, Mohtashami M, Zuniga Pflucker J, et al. Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1. Nat Methods. 2017;14:531-538 pubmed publisher
Mancini S, White A, Bijland S, Rutherford C, Graham D, Richter E, et al. Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation. Mol Cell Endocrinol. 2017;440:44-56 pubmed publisher
Harada M, Kamimura D, Arima Y, Kohsaka H, Nakatsuji Y, Nishida M, et al. Temporal expression of growth factors triggered by epiregulin regulates inflammation development. J Immunol. 2015;194:1039-46 pubmed publisher
Cho S, Pirih F, Koh A, Michalski M, Eber M, Ritchie K, et al. The soluble interleukin-6 receptor is a mediator of hematopoietic and skeletal actions of parathyroid hormone. J Biol Chem. 2013;288:6814-25 pubmed publisher
Wunderlich C, Delic D, Behnke K, Meryk A, Ströhle P, Chaurasia B, et al. Cutting edge: Inhibition of IL-6 trans-signaling protects from malaria-induced lethality in mice. J Immunol. 2012;188:4141-4 pubmed publisher
Roy M, Richard J, Dumas A, Vallières L. CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis. J Neuroinflammation. 2012;9:18 pubmed publisher
Lee S, Lee Y, Han H. Effect of arachidonic acid on hypoxia-induced IL-6 production in mouse ES cells: Involvement of MAPKs, NF-kappaB, and HIF-1alpha. J Cell Physiol. 2010;222:574-85 pubmed publisher
Osuchowski M, Siddiqui J, Copeland S, Remick D. Sequential ELISA to profile multiple cytokines from small volumes. J Immunol Methods. 2005;302:172-81 pubmed

product information

master code :

1830-SR/CF

SKU :

1830-SR-025/CF

product name :

Recombinant Mouse IL-6R alpha (aa 20-357) Protein, CF

unit size :

25 ug

description :

The Recombinant Mouse IL-6R alpha (aa 20-357) Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse IL-6R alpha (aa 20-357) Protein, CF has been validated for the following applications: Binding Activity.

target :

IL-6R alpha

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Mouse

observed molecular weight :

60-66 kDa, reducing conditions

theoretical molecular weight :

39 kDa (monomer)

gene symbol :

Il6ra

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Mouse IL-6 Protein (Catalog # 406-ML ) is immobilized at 2.00 ╡g/mL, 100 ╡L/well, Recombinant Mouse IL-6R alpha Protein (Catalog # 1830-SR/CF) binds with an ED50 of 30.0-300 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P22272

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived mouse IL-6R alpha protein Leu20-Glu357, with a C-terminal 10-His tag

source short :

NS0

USD :

432 USD

alt names :

CD126, gp80, IL-6 R alpha, IL6Q, IL6R, IL6R alpha, IL-6R-1, IL6RA, IL-6RA, IL6RQ, interleukin 6 receptor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.