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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse Klotho (aa 35-982) Protein, CF
catalog :
1819-KL-050
quantity :
50 ug
price :
456 USD
more info or order :
citations: 26
Reference
The E, Zhai Y, Yao Q, Ao L, Fullerton D, Meng X. Molecular Interaction of Soluble Klotho with FGF23 in the Pathobiology of Aortic Valve Lesions Induced by Chronic Kidney Disease. Int J Biol Sci. 2024;20:3412-3425 pubmed publisher
Orellana A, Mazucanti C, Dos Anjos L, de S xe1 Lima L, Kawamoto E, Scavone C. Klotho increases antioxidant defenses in astrocytes and ubiquitin-proteasome activity in neurons. Sci Rep. 2023;13:15080 pubmed publisher
Nakao V, Mazucanti C, de S xe1 Lima L, de Mello P, de Souza Port s N, Kinoshita P, et al. Neuroprotective action of α-Klotho against LPS-activated glia conditioned medium in primary neuronal culture. Sci Rep. 2022;12:18884 pubmed publisher
Shrestha S, Adib E, Imani J, Aguiar D, Lamattina A, Tassew D, et al. Angiotensin II receptor type 1 blockade regulates Klotho expression to induce TSC2-deficient cell death. J Biol Chem. 2022;298:102580 pubmed publisher
Wu Y, Liao W, Chen J, Liu C, Zhang S, Yu K, et al. Phosphate Metabolic Inhibition Contributes to Irradiation-Induced Myelosuppression through Dampening Hematopoietic Stem Cell Survival. Nutrients. 2022;14: pubmed publisher
Du C, Wang X, Wu Y, Liao W, Xiong J, Zhu Y, et al. Renal Klotho and inorganic phosphate are extrinsic factors that antagonistically regulate hematopoietic stem cell maintenance. Cell Rep. 2022;38:110392 pubmed publisher
Zhuang X, Sun X, Zhou H, Zhang S, Zhong X, Xu X, et al. Klotho attenuated Doxorubicin-induced cardiomyopathy by alleviating Dynamin-related protein 1 - mediated mitochondrial dysfunction. Mech Ageing Dev. 2021;195:111442 pubmed publisher
Landry T, Li P, Shookster D, Jiang Z, Li H, Laing B, et al. Centrally circulating α-klotho inversely correlates with human obesity and modulates arcuate cell populations in mice. Mol Metab. 2021;44:101136 pubmed publisher
Batlahally S, Franklin A, Damianos A, Huang J, Chen P, Sharma M, et al. Soluble Klotho, a biomarker and therapeutic strategy to reduce bronchopulmonary dysplasia and pulmonary hypertension in preterm infants. Sci Rep. 2020;10:12368 pubmed publisher
Zhang Z, Nian Q, Chen G, Cui S, Han Y, Zhang J. Klotho Alleviates Lung Injury Caused by Paraquat via Suppressing ROS/P38 MAPK-Regulated Inflammatory Responses and Apoptosis. Oxid Med Cell Longev. 2020;2020:1854206 pubmed publisher
Chen W. Soluble Alpha-Klotho Alleviates Cardiac Fibrosis without Altering Cardiomyocytes Renewal. Int J Mol Sci. 2020;21: pubmed publisher
Rao Z, Landry T, Li P, Bunner W, Laing B, Yuan Y, et al. Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice. Heliyon. 2019;5:e01494 pubmed publisher
Zhu L, Stein L, Kim D, Ho K, Yu G, Zhan L, et al. Klotho controls the brain-immune system interface in the choroid plexus. Proc Natl Acad Sci U S A. 2018;115:E11388-E11396 pubmed publisher
Arbel Rubinstein T, Shahmoon S, Zigmond E, Etan T, Merenbakh Lamin K, Pasmanik Chor M, et al. Klotho suppresses colorectal cancer through modulation of the unfolded protein response. Oncogene. 2019;38:794-807 pubmed publisher
Minamizaki T, Konishi Y, Sakurai K, Yoshioka H, Aubin J, Kozai K, et al. Soluble Klotho causes hypomineralization in Klotho-deficient mice. J Endocrinol. 2018;237:285-300 pubmed publisher
Qian Y, Guo X, Che L, Guan X, Wu B, Lu R, et al. Klotho Reduces Necroptosis by Targeting Oxidative Stress Involved in Renal Ischemic-Reperfusion Injury. Cell Physiol Biochem. 2018;45:2268-2282 pubmed publisher
Mazucanti C, Kawamoto E, Mattson M, Scavone C, Camandola S. Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis. J Cereb Blood Flow Metab. 2019;39:1544-1556 pubmed publisher
Salech F, Varela Nallar L, Arredondo S, Bustamante D, Andaur G, Cisneros R, et al. Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus. J Gerontol A Biol Sci Med Sci. 2019;74:1043-1051 pubmed publisher
Leon J, Moreno A, Garay B, Chalkley R, Burlingame A, Wang D, et al. Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice. Cell Rep. 2017;20:1360-1371 pubmed publisher
Lim S, Jin L, Luo K, Jin J, Shin Y, Hong S, et al. Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress. Cell Death Dis. 2017;8:e2972 pubmed publisher
Behera R, Kaur A, Webster M, Kim S, Ndoye A, Kugel C, et al. Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho. Clin Cancer Res. 2017;23:3181-3190 pubmed publisher
Andrukhova O, Smorodchenko A, Egerbacher M, Streicher C, Zeitz U, Goetz R, et al. FGF23 promotes renal calcium reabsorption through the TRPV5 channel. EMBO J. 2014;33:229-46 pubmed publisher
Vadakke Madathil S, Coe L, Casu C, Sitara D. Klotho deficiency disrupts hematopoietic stem cell development and erythropoiesis. Am J Pathol. 2014;184:827-41 pubmed publisher
Song S, GAO P, Xiao H, Xu Y, Si L, Si L. Klotho suppresses cardiomyocyte apoptosis in mice with stress-induced cardiac injury via downregulation of endoplasmic reticulum stress. PLoS ONE. 2013;8:e82968 pubmed publisher
Kawai M, Kinoshita S, Kimoto A, Hasegawa Y, Miyagawa K, Yamazaki M, et al. FGF23 suppresses chondrocyte proliferation in the presence of soluble ?-Klotho both in vitro and in vivo. J Biol Chem. 2013;288:2414-27 pubmed publisher
Lau W, Leaf E, Hu M, Takeno M, Kuro O M, Moe O, et al. Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet. Kidney Int. 2012;82:1261-70 pubmed publisher
product information
brand :
R&D Systems
master code :
1819-KL
SKU :
1819-KL-050
product name :
Recombinant Mouse Klotho (aa 35-982) Protein, CF
unit size :
50 ug
seo description :
The Recombinant Mouse Klotho (aa 35-982) Protein, CF from R&D Systems is derived from CHO. The Recombinant Mouse Klotho (aa 35-982) Protein, CF has been validated for the following applications: Bioactivity.
target :
Klotho
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 ╡m filtered solution in PBS, Glycerol and EDTA.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Mouse
observed molecular weight :
125-130 kDa, reducing conditions
theoretical molecular weight :
109.5 kDa
gene symbol :
Kl
details of functionality :
Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with human FGF RIIIc. The ED50 for this effect is 0.04-0.4 ╡g/mL in the presence of 1 ╡g/mL of Recombinant Human FGF-23 (Catalog # 2604-FG ) and 10 ╡g/mL of heparin.
endotoxin note :
<0.01 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
O35082.2
applications :
Bioactivity
source :
CHO-derived Recombinant Mouse Klotho (aa 35-982) Protein, CF
USD :
456 USD
alt names :
EC 3.2.1, EC 3.2.1.31, KL, klotho
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after opening.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.