Recombinant Human DLL1 His-tag Protein, CF | R&D Systems 1818-DL-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human DLL1 His-tag Protein, CF

catalog :

1818-DL-050

quantity :

50 ug

price :

400 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Jovanovic V, Weber C, Slamecka J, Ryu S, Chu P, Sen C, et al. A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells. Stem Cell Reports. 2023;18:1701-1720 pubmed publisher
Bohl B, Jabali A, Ladewig J, Koch P. Asymmetric Notch activity by differential inheritance of lysosomes in human neural stem cells. Sci Adv. 2022;8:eabl5792 pubmed publisher
Kakuda S, LoPilato R, Ito A, Haltiwanger R. Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2. J Biol Chem. 2020;295:14710-14722 pubmed publisher
Lopez Guerra M, Xargay Torrent S, Fuentes P, Roldán J, González Farre B, Rosich L, et al. Specific NOTCH1 antibody targets DLL4-induced proliferation, migration, and angiogenesis in NOTCH1-mutated CLL cells. Oncogene. 2020;39:1185-1197 pubmed publisher
Schwentner R, Jug G, Kauer M, Schnöller T, Waidhofer Söllner P, Holter W, et al. JAG2 signaling induces differentiation of CD14+ monocytes into Langerhans cell histiocytosis-like cells. J Leukoc Biol. 2019;105:101-111 pubmed publisher
Le Friec G, Sheppard D, Whiteman P, Karsten C, Shamoun S, Laing A, et al. The CD46-Jagged1 interaction is critical for human TH1 immunity. Nat Immunol. 2012;13:1213-21 pubmed publisher
Sundlisaeter E, Edelmann R, Hol J, Sponheim J, Küchler A, WEISS M, et al. The alarmin IL-33 is a notch target in quiescent endothelial cells. Am J Pathol. 2012;181:1099-111 pubmed publisher
Pang R, Leung C, Ye T, Liu W, Chiu P, Lam K, et al. MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells. Carcinogenesis. 2010;31:1037-44 pubmed publisher

product information

master code :

1818-DL

SKU :

1818-DL-050

product name :

Recombinant Human DLL1 His-tag Protein, CF

unit size :

50 ug

description :

The Recombinant Human DLL1 His-tag Protein, CF from R&D Systems is derived from NS0. The Recombinant Human DLL1 His-tag Protein, CF has been validated for the following applications: Bioactivity.

target :

DLL1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

66 kDa and 55 kDa, reducing conditions

theoretical molecular weight :

57 kDa and 43 kDa

gene symbol :

DLL1

details of functionality :

Measured by the ability of the immobilized protein to enhance BMP-2 induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells. Nobta, M. et al . (2005) J. Biol. Chem. 280 :15842. The ED50 for this effect is 0.25-1.0 ╡g/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAG09716

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human DLL1 protein Human DLL1 (Ser22-Gly540) (His152-Gly540) Accession # AAG09716 DI 6-His tag N-terminus C-terminus

source short :

NS0

USD :

400 USD

alt names :

Delta, delta (Drosophila)-like 1, Delta 1, Delta1, delta-like 1 (Drosophila), delta-like protein 1, DL1, Drosophila Delta homolog 1, H-Delta-1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage