Recombinant Mouse TIM-1/KIM-1/HAVCR Protein | R&D Systems 1817-TM-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse TIM-1/KIM-1/HAVCR Protein

catalog :

1817-TM-050

quantity :

50 ug

price :

432 USD

citations: 4

Reference
Zou X, Jiang K, Puranik A, Jordan K, Tang H, Zhu X, et al. Targeting Murine Mesenchymal Stem Cells to Kidney Injury Molecule-1 Improves Their Therapeutic Efficacy in Chronic Ischemic Kidney Injury. Stem Cells Transl Med. 2018;7:394-403 pubmed publisher
Tian L, Shao X, Xie Y, Wang Q, Che X, Zhang M, et al. Kidney Injury Molecule-1 is Elevated in Nephropathy and Mediates Macrophage Activation via the Mapk Signalling Pathway. Cell Physiol Biochem. 2017;41:769-783 pubmed publisher
Yang L, Brooks C, Xiao S, Sabbisetti V, Yeung M, Hsiao L, et al. KIM-1-mediated phagocytosis reduces acute injury to the kidney. J Clin Invest. 2015;125:1620-36 pubmed publisher
Nakae S, Iikura M, Suto H, Akiba H, Umetsu D, DeKruyff R, et al. TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells. Blood. 2007;110:2565-8 pubmed

product information

brand :

R&D Systems, a Bio-Techne brand

catalog number base :

1817-TM

SKU :

1817-TM-050

product name :

Recombinant Mouse TIM-1/KIM-1/HAVCR Protein

description :

The Recombinant Mouse TIM-1/KIM-1/HAVCR Protein from R&D Systems is derived from NS0. The Recombinant Mouse TIM-1/KIM-1/HAVCR Protein has been validated for the following applications: Bioactivity.

target :

TIM-1/KIM-1/HAVCR

unit size :

50 ug

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 µm filtered solution in Tris-Citrate and NaCl with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Mouse

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

observed molecular weight :

40-50 kDa, reducing conditions

theoretical molecular weight :

21.8 kDa

gene symbol :

Havcr1

details of functionality :

Measured by its ability to induce IL-6 or TNF-alpha secretion by RAW 264.7 mouse monocyte/macrophage cells. The ED50 for this effect is 0.1-0.4 µg/mL. Measured by its ability to bind THP-1 human acute monocytic leukemia cells. As determined by flow cytometric analysis, there is a greater than 3 fold increase in the fluorescence of apoptotic THP-1 cells treated with 0.5 µg/mL recombinant mouse TIM-1/His and Mouse Anti-polyHistidine PE-conjugated Monoclonal Antibody (Catalog # IC050P ) compared to cells stained with anti-Mouse Anti-polyHistidine PE-conjugated Monoclonal Antibody alone.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q3V033

applications :

Bioactivity

product keywords :

1817-TM, rmTIM-1, mTIM-1,, 1817TM, TIM1, TIM 1, Hepatitis A, TIMD1, Mucin, renal injury, kidney, liver, zika

source :

NS0-derived Recombinant Mouse TIM-1/KIM-1/HAVCR Protein

extended description :

This protein is in the process of being discontinued.

USD :

423

USD 2025 :

432 USD

product details :

This protein is in the process of being discontinued.

alt names :

CD365, HAVCR1, HAVCR-1, HAVCRT cell immunoglobin domain and mucin domain protein 1, hepatitis A virus cellular receptor 1, Kidney injury molecule 1, KIM1, KIM-1, T-cell immunoglobulin and mucin domain-containing protein 1, TIM1, TIM-1TIM, TIM1TIMD-1, TIMD1T-cell membrane protein 1