Recombinant Human Endocan Protein | R&D Systems 1810-EC-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Endocan Protein

catalog :

1810-EC-050

quantity :

50 ug

price :

456 USD

citations: 6

Reference
Ghochani Y, Muthukrishnan S, Sohrabi A, Kawaguchi R, Condro M, Bastola S, et al. A molecular interactome of the glioblastoma perivascular niche reveals integrin binding sialoprotein as a mediator of tumor cell migration. Cell Rep. 2022;41:111511 pubmed publisher
Yang Y, Pan K, Lee W, Chang J, Tan P, Gu C, et al. Circulating proteoglycan endocan mediates EGFR-driven progression of non-small cell lung cancer. Cancer Res. 2020;: pubmed publisher
Zheng X, Soroush F, Long J, Hall E, Adishesha P, Bhattacharya S, et al. Murine glomerular transcriptome links endothelial cell-specific molecule-1 deficiency with susceptibility to diabetic nephropathy. PLoS ONE. 2017;12:e0185250 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Shin J, Huggenberger R, Detmar M. Transcriptional profiling of VEGF-A and VEGF-C target genes in lymphatic endothelium reveals endothelial-specific molecule-1 as a novel mediator of lymphangiogenesis. Blood. 2008;112:2318-26 pubmed publisher
Rennel E, Mellberg S, Dimberg A, Petersson L, Botling J, Ameur A, et al. Endocan is a VEGF-A and PI3K regulated gene with increased expression in human renal cancer. Exp Cell Res. 2007;313:1285-94 pubmed

product information

master code :

1810-EC

SKU :

1810-EC-050

product name :

Recombinant Human Endocan Protein

unit size :

50 ug

description :

The Recombinant Human Endocan Protein from R&D Systems is derived from NS0. The Recombinant Human Endocan Protein has been validated for the following applications: Bioactivity.

target :

Endocan/ESM-1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

24-27 kDa, reducing conditions

theoretical molecular weight :

19.5 kDa

gene symbol :

ESM1

details of functionality :

Measured by its ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells. Bechard, D. et al . (2001) J. Immunol. 167 :3099. When 1 x 105 cells/well are added to Recombinant Human Endocan/ESM coated plates, adhesion is induced in a dose dependent manner after a 1 hour incubation at 37 ░C. The ED50 for this effect is 2-10 ╡g/mL. Optimal dilutions should be determined by each laboratory for each application.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q9NQ30

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human Endocan/ESM-1 protein Trp20-Arg184, with a C-terminal 10-His tag

source short :

NS0

USD :

456 USD

alt names :

endocan, endothelial cell-specific molecule 1, ESM1, ESM-1, IGFBP-rp6

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.