Recombinant Human Chordin-Like 1 Protein | R&D Systems 1808-NR-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Chordin-Like 1 Protein

catalog :

1808-NR-050

quantity :

50 ug

price :

552 USD

more info or order :

R&D Systems product webpage

citations: 7

Reference
O Sullivan J, Blacker T, Scott C, Chang W, Ahmed M, Yianni V, et al. Gradients of glucose metabolism regulate morphogen signalling required for specifying tonotopic organisation in the chicken cochlea. elife. 2023;12: pubmed publisher
Mann Z, Thiede B, Chang W, Shin J, May Simera H, Lovett M, et al. A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear. Nat Commun. 2014;5:3839 pubmed publisher
Olsen O, Wader K, Misund K, Våtsveen T, Rø T, Mylin A, et al. Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin. Blood Cancer J. 2014;4:e196 pubmed publisher
Zhang Y, Liu J, Tian X, Wong W, Chen Y, Wang L, et al. Inhibition of bone morphogenic protein 4 restores endothelial function in db/db diabetic mice. Arterioscler Thromb Vasc Biol. 2014;34:152-9 pubmed publisher
Talavera Adame D, Gupta A, Kurtovic S, Chaiboonma K, Arumugaswami V, Dafoe D. Bone morphogenetic protein-2/-4 upregulation promoted by endothelial cells in coculture enhances mouse embryoid body differentiation. Stem Cells Dev. 2013;22:3252-60 pubmed publisher
Alborzinia H, Schmidt Glenewinkel H, Ilkavets I, Breitkopf Heinlein K, Cheng X, Hortschansky P, et al. Quantitative kinetics analysis of BMP2 uptake into cells and its modulation by BMP antagonists. J Cell Sci. 2013;126:117-27 pubmed publisher
Kane R, Godson C, O Brien C. Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis. Mol Vis. 2008;14:1138-48 pubmed

product information

brand :

R&D Systems

master code :

1808-NR

SKU :

1808-NR-050

product name :

Recombinant Human Chordin-Like 1 Protein

unit size :

50 ug

seo description :

The Recombinant Human Chordin-Like 1 Protein from R&D Systems is derived from NS0. The Recombinant Human Chordin-Like 1 Protein has been validated for the following applications: Bioactivity.

target :

Chordin-like 1/CHRDL1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

60 kDa, reducing conditions

theoretical molecular weight :

50 kDa

gene symbol :

CHRDL1

details of functionality :

Measured by its ability to inhibit BMP-4-induced activity in MC3T3-E1 mouse preosteoblast cells. The ED50 for this effect is 0.7-3.5 ╡g/mL in the presence of 50 ng/mL Recombinant Human BMP-4 Recombinant Human BMP-4 (Catalog # 314-BP ) and 1 ╡g/mL of Recombinant Human TSG (Catalog # 6684-TG ).

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q9BU40.2

applications :

Bioactivity

source :

NS0-derived Recombinant Human Chordin-Like 1 Protein

USD :

552 USD

alt names :

CHL, chordin-like 1, chordin-like protein 1, CHRDL1, CRDL1, dA141H5.1, Neuralin 1, neuralin-1, Neurogenesin-1, NRLN1, NRLN1neuralin 1, ventroptin, Ventroptin alpha, VOPT

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage