Recombinant Human Complement Component C1r Protein, CF | R&D Systems 1807-SE-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Complement Component C1r Protein, CF

catalog :

1807-SE-010

quantity :

10 ug

price :

541 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Uchio Yamada K, Tanaka M, Manabe N. C1r/C1s deficiency is insufficient to induce murine systemic lupus erythematosus. Genes Immun. 2019;20:121-130 pubmed publisher
Zhou Z, Chen T, Arora K, Hyams K, Kozlowski S. Complement C1 esterase inhibitor levels linked to infections and contaminated heparin-associated adverse events. PLoS ONE. 2012;7:e34978 pubmed publisher
Ruan B, Li X, Winkler A, Cunningham K, Kuai J, Greco R, et al. Complement C3a, CpG oligos, and DNA/C3a complex stimulate IFN-? production in a receptor for advanced glycation end product-dependent manner. J Immunol. 2010;185:4213-22 pubmed publisher
Abe K, Endo Y, Nakazawa N, Kanno K, Okubo M, Hoshino T, et al. Unique phenotypes of C1s deficiency and abnormality caused by two compound heterozygosities in a Japanese family. J Immunol. 2009;182:1681-8 pubmed

product information

brand :

R&D Systems

master code :

1807-SE

SKU :

1807-SE-010

product name :

Recombinant Human Complement Component C1r Protein, CF

unit size :

10 ug

seo description :

The Recombinant Human Complement Component C1r Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Complement Component C1r Protein, CF has been validated for the following applications: Enzyme Activity.

target :

Complement Component C1r

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Tris and NaCl.

conjugate :

Unconjugated

dilution :

Enzyme Activity

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

60 kDa 40 kDa, reducing conditions

theoretical molecular weight :

51 kDa (A chain) 28 kDa (B chain)

gene symbol :

C1R

details of functionality :

Measured by its ability to cleave a colorimetric peptide substrate, N-carbobenzyloxy-Gly-Arg-ThioBenzyl ester (Z-GR-SBzl), in the presence of 5,5ÆDithio-bis (2-nitrobenzoic acid) (DTNB). Edwards, K.M. et al . (1999) J. Biol. Chem. 274 :30468. The specific activity is 1,500 pmol/min/╡g, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

NP_001724

applications :

Enzyme Activity

source :

NS0-derived Recombinant Human Complement Component C1r Protein, CF

USD :

541 USD

alt names :

C1r, complement C1r subcomponent, Complement component 1 subcomponent r, complement component 1, r subcomponent, EC 3.4.21, EC 3.4.21.41

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage