Recombinant Mouse LIGHT/TNFSF14 Protein, CF | R&D Systems 1794-LT-025/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse LIGHT/TNFSF14 Protein, CF

catalog :

1794-LT-025/CF

quantity :

25 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Liang Q, Xie J, Yu C, Feng Z, Ma J, Zhang Y, et al. Splenectomy improves liver fibrosis via tumor necrosis factor superfamily 14 (LIGHT) through the JNK/TGF-β1 signaling pathway. Exp Mol Med. 2021;53:393-406 pubmed publisher
Sibilano R, Gaudenzio N, DeGorter M, Reber L, Hernandez J, Starkl P, et al. A TNFRSF14-Fc?RI-mast cell pathway contributes to development of multiple features of asthma pathology in mice. Nat Commun. 2016;7:13696 pubmed publisher
Herro R, Antunes R, Aguilera A, Tamada K, Croft M. The Tumor Necrosis Factor Superfamily Molecule LIGHT Promotes Keratinocyte Activity and Skin Fibrosis. J Invest Dermatol. 2015;135:2109-2118 pubmed publisher
Freeman B, Hammarlund E, Raué H, Slifka M. Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A. 2012;109:9971-6 pubmed publisher
Doherty T, Soroosh P, Khorram N, Fukuyama S, Rosenthal P, Cho J, et al. The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling. Nat Med. 2011;17:596-603 pubmed publisher
Aebischer J, Cassina P, Otsmane B, Moumen A, Seilhean D, Meininger V, et al. IFN? triggers a LIGHT-dependent selective death of motoneurons contributing to the non-cell-autonomous effects of mutant SOD1. Cell Death Differ. 2011;18:754-68 pubmed publisher
Kayamuro H, Yoshioka Y, Abe Y, Katayama K, Yoshida T, Yamashita K, et al. TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant. Biochem Biophys Res Commun. 2009;384:296-300 pubmed publisher
Mueller A, Pedre X, Killian S, David M, Steinbrecher A. The Decoy Receptor 3 (DcR3, TNFRSF6B) suppresses Th17 immune responses and is abundant in human cerebrospinal fluid. J Neuroimmunol. 2009;209:57-64 pubmed publisher

product information

master code :

1794-LT/CF

SKU :

1794-LT-025/CF

product name :

Recombinant Mouse LIGHT/TNFSF14 Protein, CF

unit size :

25 ug

description :

The Recombinant Mouse LIGHT/TNFSF14 Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse LIGHT/TNFSF14 Protein, CF has been validated for the following applications: Bioactivity.

target :

LIGHT/TNFSF14

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Mouse

observed molecular weight :

24-34 kDa, reducing conditions

theoretical molecular weight :

21 kDa

gene symbol :

Tnfsf14

details of functionality :

Measured in a cytotoxicity assay using HT-29 human colon adenocarcinoma cells Yu,áK.Y. etáal . (1999) J.áBiol. Chem. 274 :13733; Harrop,áJ.A. etáal . (1998) J.áBiol. Chem. 273 :27548; Zhai,áY. etáal . (1998) J.áClin. Invest. 102 :1142. The ED50 for this effect is 2-5 ╡g/mL in the presence of a cross-linking antibody, Mouse Anti-polyHistidine Monoclonal Antibody (Catalog # MAB050 ) and recombinant human IFN-gamma .

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q9QYH9

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived mouse LIGHT/TNFSF14 protein MHHHHHHHHHH GGGSGGGSGGGS IEGR Mouse LIGHT (Asp72-Val239) Accession # Q9QYH9 N-terminus C-terminus

source short :

NS0

USD :

432 USD

alt names :

CD258, CD258 antigen, delta transmembrane LIGHT, Herpes virus entry mediator ligand, Herpesvirus entry mediator ligand, HVEM-L, HVEMLherpesvirus entry mediator-ligand, ligand for herpesvirus entry mediator, LIGHTherpesvirus entry mediator A, LTg, TNFSF14, TR2, tumor necrosis factor (ligand) superfamily, member 14, tumor necrosis factor ligand superfamily member 14, tumor necrosis factor receptor-like 2, tumor necrosis factor superfamily member LIGHT

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage