Recombinant Human Serpin E1/PAI-1 Protein, CF | R&D Systems 1786-PI-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Serpin E1/PAI-1 Protein, CF

catalog :

1786-PI-010

quantity :

10 ug

price :

400 USD

more info or order :

R&D Systems product webpage

citations: 10

Reference
Lin L, Nayak B, Osmulski P, Wang E, Wang C, Valente P, et al. PAI-1 uncouples integrin-β1 from restrain by membrane-bound β-catenin to promote collagen fibril remodeling in obesity-related neoplasms. Cell Rep. 2024;43:114527 pubmed publisher
Infante A, RodrÃguez C. Secretome analysis of in vitro aged human mesenchymal stem cells reveals IGFBP7 as a putative factor for promoting osteogenesis. Sci Rep. 2018;8:4632 pubmed publisher
MikuÅ‚a Pietrasik J, Uruski P, SosiÅ„ska P, Maksin K, Piotrowska Kempisty H, KuciÅ„ska M, et al. Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases. Cell Death Dis. 2016;7:e2565 pubmed publisher
Doni A, Musso T, Morone D, Bastone A, Zambelli V, Sironi M, et al. An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode. J Exp Med. 2015;212:905-25 pubmed publisher
Santhekadur P, Akiel M, Emdad L, Gredler R, Srivastava J, Rajasekaran D, et al. Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGF? signaling. FEBS Open Bio. 2014;4:353-61 pubmed publisher
Krstic D, Rodríguez M, Knuesel I. Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators. PLoS ONE. 2012;7:e47793 pubmed publisher
Schipper H, de Jager W, van Dijk M, Meerding J, Zelissen P, Adan R, et al. A multiplex immunoassay for human adipokine profiling. Clin Chem. 2010;56:1320-8 pubmed publisher
Huang M, Patel K, Taub D, Longo D, Goetzl E. Human CD4- 8- T cells are a distinctive immunoregulatory subset. FASEB J. 2010;24:2558-66 pubmed publisher
Szabo R, Hobson J, List K, Molinolo A, Lin C, Bugge T. Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity. J Biol Chem. 2008;283:29495-504 pubmed publisher
Memari N, Jiang W, Diamandis E, Luo L. Enzymatic properties of human kallikrein-related peptidase 12 (KLK12). Biol Chem. 2007;388:427-35 pubmed

product information

brand :

R&D Systems

master code :

1786-PI

SKU :

1786-PI-010

product name :

Recombinant Human Serpin E1/PAI-1 Protein, CF

unit size :

10 ug

seo description :

The Recombinant Human Serpin E1/PAI-1 Protein, CF from R&D Systems is derived from Sf 21 (stably transfected). The Recombinant Human Serpin E1/PAI-1 Protein, CF has been validated for the following applications: Inhibition Activity.

target :

Serpin E1/PAI-1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Sodium Acetate, NaCl and CHAPS.

conjugate :

Unconjugated

dilution :

Inhibition Activity

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

43 kDa, reducing conditions

theoretical molecular weight :

44 kDa

gene symbol :

SERPINE1

details of functionality :

Measured by its ability to inhibit uPA cleavage of a peptide substrate, N-carbobenzyloxy-Gly-Gly-Arg-7-amido-4-methylcoumarin (Z-GGR-AMC). The IC50 value is 13 nM, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Human Serpin E1/PAI-1 Protein Enzyme Activity

accessionNumbers :

P05121

applications :

Inhibition Activity

source :

Sf 21 (stably transfected)-derived Recombinant Human Serpin E1/PAI-1 Protein, CF

USD :

400 USD

alt names :

Endothelial plasminogen activator inhibitor, Nexin, PAI1, PAI-1, PAI1PAI-1, PAISerpin E1, PLANH1, PLANH1plasminogen activator inhibitor 1, serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogenactivator inhibitor type 1), member 1, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitortype 1), member 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage